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Results: 1 to 20 of 129

1.

Development of screening assays and discovery of initial inhibitors of pneumococcal peptidoglycan deacetylase PgdA.

Bui NK, Turk S, Buckenmaier S, Stevenson-Jones F, Zeuch B, Gobec S, Vollmer W.

Biochem Pharmacol. 2011 Jul 1;82(1):43-52. doi: 10.1016/j.bcp.2011.03.028. Epub 2011 Apr 8.

PMID:
21501597
[PubMed - indexed for MEDLINE]
2.

The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae.

Vollmer W, Tomasz A.

J Biol Chem. 2000 Jul 7;275(27):20496-501.

PMID:
10781617
[PubMed - indexed for MEDLINE]
Free Article
3.

Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae.

Vollmer W, Tomasz A.

Infect Immun. 2002 Dec;70(12):7176-8.

PMID:
12438406
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Inhibitors of Streptococcus pneumoniae surface endonuclease EndA discovered by high-throughput screening using a PicoGreen fluorescence assay.

Peterson EJ, Kireev D, Moon AF, Midon M, Janzen WP, Pingoud A, Pedersen LC, Singleton SF.

J Biomol Screen. 2013 Mar;18(3):247-57. doi: 10.1177/1087057112461153. Epub 2012 Sep 26.

PMID:
23015019
[PubMed - indexed for MEDLINE]
5.

Resistance to mucosal lysozyme compensates for the fitness deficit of peptidoglycan modifications by Streptococcus pneumoniae.

Davis KM, Akinbi HT, Standish AJ, Weiser JN.

PLoS Pathog. 2008 Dec;4(12):e1000241. doi: 10.1371/journal.ppat.1000241. Epub 2008 Dec 12.

PMID:
19079576
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Helicobacter pylori peptidoglycan modifications confer lysozyme resistance and contribute to survival in the host.

Wang G, Lo LF, Forsberg LS, Maier RJ.

MBio. 2012 Dec 4;3(6):e00409-12. doi: 10.1128/mBio.00409-12.

PMID:
23221800
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Screening for antibacterial inhibitors of the UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) using a high-throughput mass spectrometry assay.

Langsdorf EF, Malikzay A, Lamarr WA, Daubaras D, Kravec C, Zhang R, Hart R, Monsma F, Black T, Ozbal CC, Miesel L, Lunn CA.

J Biomol Screen. 2010 Jan;15(1):52-61. doi: 10.1177/1087057109355319. Epub 2009 Dec 17.

PMID:
20019290
[PubMed - indexed for MEDLINE]
8.

Streptococcus pneumononiae gyrase ATPase: development and validation of an assay for inhibitor discovery and characterization.

Miller JR, Herberg JT, Tomilo M, McCroskey MC, Feilmeier BJ.

Anal Biochem. 2007 Jun 1;365(1):132-43. Epub 2007 Feb 27.

PMID:
17395144
[PubMed - indexed for MEDLINE]
9.

Inactivation of the wall-associated de-N-acetylase (PgdA) of Listeria monocytogenes results in greater susceptibility of the cells to induced autolysis.

Popowska M, Kusio M, Szymanska P, Markiewicz Z.

J Microbiol Biotechnol. 2009 Sep;19(9):932-45.

PMID:
19809250
[PubMed - indexed for MEDLINE]
10.

The lysozyme-induced peptidoglycan N-acetylglucosamine deacetylase PgdA (EF1843) is required for Enterococcus faecalis virulence.

Benachour A, Ladjouzi R, Le Jeune A, Hébert L, Thorpe S, Courtin P, Chapot-Chartier MP, Prajsnar TK, Foster SJ, Mesnage S.

J Bacteriol. 2012 Nov;194(22):6066-73. doi: 10.1128/JB.00981-12. Epub 2012 Sep 7.

PMID:
22961856
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Peptidoglycan deacetylation in Helicobacter pylori contributes to bacterial survival by mitigating host immune responses.

Wang G, Maier SE, Lo LF, Maier G, Dosi S, Maier RJ.

Infect Immun. 2010 Nov;78(11):4660-6. doi: 10.1128/IAI.00307-10. Epub 2010 Aug 30.

PMID:
20805339
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents.

Jain R, Chen D, White RJ, Patel DV, Yuan Z.

Curr Med Chem. 2005;12(14):1607-21. Review.

PMID:
16022661
[PubMed - indexed for MEDLINE]
13.

Enterococcus faecalis constitutes an unusual bacterial model in lysozyme resistance.

Hébert L, Courtin P, Torelli R, Sanguinetti M, Chapot-Chartier MP, Auffray Y, Benachour A.

Infect Immun. 2007 Nov;75(11):5390-8. Epub 2007 Sep 4.

PMID:
17785473
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening.

Miguet L, Zervosen A, Gerards T, Pasha FA, Luxen A, Distèche-Nguyen M, Thomas A.

J Med Chem. 2009 Oct 8;52(19):5926-36. doi: 10.1021/jm900625q.

PMID:
19746934
[PubMed - indexed for MEDLINE]
15.

Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ).

Miller K, Dunsmore CJ, Leeds JA, Patching SG, Sachdeva M, Blake KL, Stubbings WJ, Simmons KJ, Henderson PJ, De Los Angeles J, Fishwick CW, Chopra I.

J Antimicrob Chemother. 2010 Dec;65(12):2566-73. doi: 10.1093/jac/dkq349. Epub 2010 Sep 22.

PMID:
20861142
[PubMed - indexed for MEDLINE]
Free Article
16.

Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis.

Pluvinage B, Higgins MA, Abbott DW, Robb C, Dalia AB, Deng L, Weiser JN, Parsons TB, Fairbanks AJ, Vocadlo DJ, Boraston AB.

Structure. 2011 Nov 9;19(11):1603-14. doi: 10.1016/j.str.2011.08.011.

PMID:
22078560
[PubMed - indexed for MEDLINE]
Free Article
17.

The novel polysaccharide deacetylase homologue Pdi contributes to virulence of the aquatic pathogen Streptococcus iniae.

Milani CJ, Aziz RK, Locke JB, Dahesh S, Nizet V, Buchanan JT.

Microbiology. 2010 Feb;156(Pt 2):543-54. doi: 10.1099/mic.0.028365-0. Epub 2009 Sep 17.

PMID:
19762441
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system.

Boneca IG, Dussurget O, Cabanes D, Nahori MA, Sousa S, Lecuit M, Psylinakis E, Bouriotis V, Hugot JP, Giovannini M, Coyle A, Bertin J, Namane A, Rousselle JC, Cayet N, Prévost MC, Balloy V, Chignard M, Philpott DJ, Cossart P, Girardin SE.

Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):997-1002. Epub 2007 Jan 10.

PMID:
17215377
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase.

Brooks WH, McCloskey DE, Daniel KG, Ealick SE, Secrist JA 3rd, Waud WR, Pegg AE, Guida WC.

J Chem Inf Model. 2007 Sep-Oct;47(5):1897-905. Epub 2007 Aug 4.

PMID:
17676832
[PubMed - indexed for MEDLINE]
20.

Oxidative stress-induced peptidoglycan deacetylase in Helicobacter pylori.

Wang G, Olczak A, Forsberg LS, Maier RJ.

J Biol Chem. 2009 Mar 13;284(11):6790-800. doi: 10.1074/jbc.M808071200. Epub 2009 Jan 15.

PMID:
19147492
[PubMed - indexed for MEDLINE]
Free PMC Article

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