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SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants.

Welz C, Krüger N, Schniederjans M, Miltsch SM, Krücken J, Guest M, Holden-Dye L, Harder A, von Samson-Himmelstjerna G.

PLoS Pathog. 2011 Apr;7(4):e1001330. doi: 10.1371/journal.ppat.1001330. Epub 2011 Apr 7.


Worms take to the slo lane: a perspective on the mode of action of emodepside.

Holden-Dye L, Crisford A, Welz C, von Samson-Himmelstjerna G, Walker RJ, O'Connor V.

Invert Neurosci. 2012 Jun;12(1):29-36. doi: 10.1007/s10158-012-0133-x. Epub 2012 Apr 27. Review.


The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans.

Guest M, Bull K, Walker RJ, Amliwala K, O'Connor V, Harder A, Holden-Dye L, Hopper NA.

Int J Parasitol. 2007 Dec;37(14):1577-88. Epub 2007 May 21.


Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside.

Kulke D, von Samson-Himmelstjerna G, Miltsch SM, Wolstenholme AJ, Jex AR, Gasser RB, Ballesteros C, Geary TG, Keiser J, Townson S, Harder A, Krücken J.

PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3401. doi: 10.1371/journal.pntd.0003401. eCollection 2014 Dec.


Selective toxicity of the anthelmintic emodepside revealed by heterologous expression of human KCNMA1 in Caenorhabditis elegans.

Crisford A, Murray C, O'Connor V, Edwards RJ, Kruger N, Welz C, von Samson-Himmelstjerna G, Harder A, Walker RJ, Holden-Dye L.

Mol Pharmacol. 2011 Jun;79(6):1031-43. doi: 10.1124/mol.111.071043. Epub 2011 Mar 17.


Decreased emodepside sensitivity in unc-49 γ-aminobutyric acid (GABA)-receptor-deficient Caenorhabditis elegans.

Miltsch SM, Krücken J, Demeler J, Janssen IJ, Krüger N, Harder A, von Samson-Himmelstjerna G.

Int J Parasitol. 2012 Jul;42(8):761-70. doi: 10.1016/j.ijpara.2012.05.009. Epub 2012 Jun 19.


Interactions of anthelmintic drugs in Caenorhabditis elegans neuro-muscular ion channel mutants.

Miltsch SM, Krücken J, Demeler J, Ramünke S, Harder A, von Samson-Himmelstjerna G.

Parasitol Int. 2013 Dec;62(6):591-8. doi: 10.1016/j.parint.2013.05.006. Epub 2013 May 24.


Caenorhabditis elegans ivermectin receptors regulate locomotor behaviour and are functional orthologues of Haemonchus contortus receptors.

Cook A, Aptel N, Portillo V, Siney E, Sihota R, Holden-Dye L, Wolstenholme A.

Mol Biochem Parasitol. 2006 May;147(1):118-25. Epub 2006 Feb 24.


SLO, SLO, quick, quick, slow: calcium-activated potassium channels as regulators of Caenorhabditis elegans behaviour and targets for anthelmintics.

Holden-Dye L, O'Connor V, Hopper NA, Walker RJ, Harder A, Bull K, Guest M.

Invert Neurosci. 2007 Dec;7(4):199-208. Epub 2007 Oct 26. Review.


The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits.

Crisford A, Ebbinghaus-Kintscher U, Schoenhense E, Harder A, Raming K, O'Kelly I, Ndukwe K, O'Connor V, Walker RJ, Holden-Dye L.

PLoS Negl Trop Dis. 2015 Oct 5;9(10):e0004062. doi: 10.1371/journal.pntd.0004062. eCollection 2015.


The putative cyclooctadepsipeptide receptor depsiphilin of the canine hookworm Ancylostoma caninum.

Krüger N, Harder A, von Samson-Himmelstjerna G.

Parasitol Res. 2009 Aug;105 Suppl 1:S91-100. doi: 10.1007/s00436-009-1500-3.


On being the right size: the impact of population size and stochastic effects on the evolution of drug resistance in hospitals and the community.

Kouyos RD, Abel Zur Wiesch P, Bonhoeffer S.

PLoS Pathog. 2011 Apr;7(4):e1001334. doi: 10.1371/journal.ppat.1001334. Epub 2011 Apr 14.


Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans.

Glendinning SK, Buckingham SD, Sattelle DB, Wonnacott S, Wolstenholme AJ.

PLoS One. 2011;6(7):e22390. doi: 10.1371/journal.pone.0022390. Epub 2011 Jul 26.


Putative G protein-coupled receptors in parasitic nematodes--potential targets for the new anthelmintic class cyclooctadepsipeptides?

Welz C, Harder A, Schnieder T, Hoglund J, von Samson-Himmelstjerna G.

Parasitol Res. 2005 Oct;97 Suppl 1:S22-32. Erratum in: Parasitol Res. 2007 Feb;100(3):669. Weiz, C [corrected to Welz, C].


On the mode of action of emodepside: slow effects on membrane potential and voltage-activated currents in Ascaris suum.

Buxton SK, Neveu C, Charvet CL, Robertson AP, Martin RJ.

Br J Pharmacol. 2011 Sep;164(2b):453-70. doi: 10.1111/j.1476-5381.2011.01428.x.


Emodepside and SL0-1 potassium channels: a review.

Martin RJ, Buxton SK, Neveu C, Charvet CL, Robertson AP.

Exp Parasitol. 2012 Sep;132(1):40-6. doi: 10.1016/j.exppara.2011.08.012. Epub 2011 Sep 3. Review.


Heterologous Expression in Remodeled C. elegans: A Platform for Monoaminergic Agonist Identification and Anthelmintic Screening.

Law W, Wuescher LM, Ortega A, Hapiak VM, Komuniecki PR, Komuniecki R.

PLoS Pathog. 2015 Apr 30;11(4):e1004794. doi: 10.1371/journal.ppat.1004794. eCollection 2015 Apr.


Structural and functional characterisation of the fork head transcription factor-encoding gene, Hc-daf-16, from the parasitic nematode Haemonchus contortus (Strongylida).

Hu M, Lok JB, Ranjit N, Massey HC Jr, Sternberg PW, Gasser RB.

Int J Parasitol. 2010 Mar 15;40(4):405-15. doi: 10.1016/j.ijpara.2009.09.005. Epub 2009 Sep 29.


Effects of the novel anthelmintic emodepside on the locomotion, egg-laying behaviour and development of Caenorhabditis elegans.

Bull K, Cook A, Hopper NA, Harder A, Holden-Dye L, Walker RJ.

Int J Parasitol. 2007 May;37(6):627-36. Epub 2006 Nov 27.

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