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Results: 1 to 20 of 95

Similar articles for PubMed (Select 21490391)

1.

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.

Holland WL, Bikman BT, Wang LP, Yuguang G, Sargent KM, Bulchand S, Knotts TA, Shui G, Clegg DJ, Wenk MR, Pagliassotti MJ, Scherer PE, Summers SA.

J Clin Invest. 2011 May;121(5):1858-70. doi: 10.1172/JCI43378. Epub 2011 Apr 1.

2.

Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity.

Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, Thaler J, Hawn TR, Raines EW, Schwartz MW.

Circ Res. 2007 Jun 8;100(11):1589-96. Epub 2007 May 3.

3.

A high ratio of dietary n-3/n-6 polyunsaturated fatty acids improves obesity-linked inflammation and insulin resistance through suppressing activation of TLR4 in SD rats.

Liu HQ, Qiu Y, Mu Y, Zhang XJ, Liu L, Hou XH, Zhang L, Xu XN, Ji AL, Cao R, Yang RH, Wang F.

Nutr Res. 2013 Oct;33(10):849-58. doi: 10.1016/j.nutres.2013.07.004. Epub 2013 Aug 9.

PMID:
24074743
4.

TLR4 links innate immunity and fatty acid-induced insulin resistance.

Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS.

J Clin Invest. 2006 Nov;116(11):3015-25. Epub 2006 Oct 19.

5.

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance.

Pal D, Dasgupta S, Kundu R, Maitra S, Das G, Mukhopadhyay S, Ray S, Majumdar SS, Bhattacharya S.

Nat Med. 2012 Aug;18(8):1279-85. doi: 10.1038/nm.2851. Epub 2012 Jul 29.

PMID:
22842477
6.

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance.

Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, Liu Y, Narra K, Hoehn KL, Knotts TA, Siesky A, Nelson DH, Karathanasis SK, Fontenot GK, Birnbaum MJ, Summers SA.

Cell Metab. 2007 Mar;5(3):167-79.

7.

Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages.

Schilling JD, Machkovech HM, He L, Sidhu R, Fujiwara H, Weber K, Ory DS, Schaffer JE.

J Biol Chem. 2013 Feb 1;288(5):2923-32. doi: 10.1074/jbc.M112.419978. Epub 2012 Dec 18.

8.

Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance.

Boon J, Hoy AJ, Stark R, Brown RD, Meex RC, Henstridge DC, Schenk S, Meikle PJ, Horowitz JF, Kingwell BA, Bruce CR, Watt MJ.

Diabetes. 2013 Feb;62(2):401-10. doi: 10.2337/db12-0686. Epub 2012 Nov 8.

9.

Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites.

Lee JS, Pinnamaneni SK, Eo SJ, Cho IH, Pyo JH, Kim CK, Sinclair AJ, Febbraio MA, Watt MJ.

J Appl Physiol (1985). 2006 May;100(5):1467-74. Epub 2005 Dec 15.

10.

TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells.

Hussey SE, Liang H, Costford SR, Klip A, DeFronzo RA, Sanchez-Avila A, Ely B, Musi N.

Biosci Rep. 2012 Nov 30;33(1):37-47. doi: 10.1042/BSR20120098.

11.

Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.

Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, Tsukumo DM, Anhe G, Amaral ME, Takahashi HK, Curi R, Oliveira HC, Carvalheira JB, Bordin S, Saad MJ, Velloso LA.

J Neurosci. 2009 Jan 14;29(2):359-70. doi: 10.1523/JNEUROSCI.2760-08.2009.

12.

Adipose tissue and ceramide biosynthesis in the pathogenesis of obesity.

Samad F, Badeanlou L, Shah C, Yang G.

Adv Exp Med Biol. 2011;721:67-86. doi: 10.1007/978-1-4614-0650-1_5. Review.

PMID:
21910083
13.
14.

Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice.

Ding Y, Subramanian S, Montes VN, Goodspeed L, Wang S, Han C, Teresa AS 3rd, Kim J, O'Brien KD, Chait A.

Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1596-604. doi: 10.1161/ATVBAHA.112.249847. Epub 2012 May 10.

15.

Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance.

Reynolds CM, McGillicuddy FC, Harford KA, Finucane OM, Mills KH, Roche HM.

Mol Nutr Food Res. 2012 Aug;56(8):1212-22. doi: 10.1002/mnfr.201200058. Epub 2012 Jun 15.

PMID:
22700321
16.

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo.

Galbo T, Perry RJ, Jurczak MJ, Camporez JP, Alves TC, Kahn M, Guigni BA, Serr J, Zhang D, Bhanot S, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12780-5. doi: 10.1073/pnas.1311176110. Epub 2013 Jul 9.

17.

Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1.

Shah C, Yang G, Lee I, Bielawski J, Hannun YA, Samad F.

J Biol Chem. 2008 May 16;283(20):13538-48. doi: 10.1074/jbc.M709950200. Epub 2008 Mar 22.

18.
19.

Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids.

Lee JY, Ye J, Gao Z, Youn HS, Lee WH, Zhao L, Sizemore N, Hwang DH.

J Biol Chem. 2003 Sep 26;278(39):37041-51. Epub 2003 Jul 15.

20.

Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner.

Wong SW, Kwon MJ, Choi AM, Kim HP, Nakahira K, Hwang DH.

J Biol Chem. 2009 Oct 2;284(40):27384-92. doi: 10.1074/jbc.M109.044065. Epub 2009 Aug 1.

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