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Results: 1 to 20 of 115

1.

Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.

Xing S, Bullen CK, Shroff NS, Shan L, Yang HC, Manucci JL, Bhat S, Zhang H, Margolick JB, Quinn TC, Margolis DM, Siliciano JD, Siliciano RF.

J Virol. 2011 Jun;85(12):6060-4. doi: 10.1128/JVI.02033-10. Epub 2011 Apr 6.

PMID:
21471244
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation.

Yang HC, Xing S, Shan L, O'Connell K, Dinoso J, Shen A, Zhou Y, Shrum CK, Han Y, Liu JO, Zhang H, Margolick JB, Siliciano RF.

J Clin Invest. 2009 Nov;119(11):3473-86. doi: 10.1172/JCI39199. Epub 2009 Oct 1.

PMID:
19805909
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.

Xing S, Bhat S, Shroff NS, Zhang H, Lopez JA, Margolick JB, Liu JO, Siliciano RF.

J Antimicrob Chemother. 2012 Feb;67(2):398-403. doi: 10.1093/jac/dkr496. Epub 2011 Dec 7.

PMID:
22160146
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog.

Doyon G, Zerbato J, Mellors JW, Sluis-Cremer N.

AIDS. 2013 Jan 14;27(2):F7-F11. doi: 10.1097/QAD.0b013e3283570620.

PMID:
22739395
[PubMed - indexed for MEDLINE]
5.

Unique characteristics of histone deacetylase inhibitors in reactivation of latent HIV-1 in Bcl-2-transduced primary resting CD4+ T cells.

Shan L, Xing S, Yang HC, Zhang H, Margolick JB, Siliciano RF.

J Antimicrob Chemother. 2014 Jan;69(1):28-33. doi: 10.1093/jac/dkt338. Epub 2013 Sep 1.

PMID:
23999005
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1.

Doyon G, Sobolewski MD, Huber K, McMahon D, Mellors JW, Sluis-Cremer N.

PLoS One. 2014 Jan 29;9(1):e84964. doi: 10.1371/journal.pone.0084964. eCollection 2014.

PMID:
24489654
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing.

Wei DG, Chiang V, Fyne E, Balakrishnan M, Barnes T, Graupe M, Hesselgesser J, Irrinki A, Murry JP, Stepan G, Stray KM, Tsai A, Yu H, Spindler J, Kearney M, Spina CA, McMahon D, Lalezari J, Sloan D, Mellors J, Geleziunas R, Cihlar T.

PLoS Pathog. 2014 Apr 10;10(4):e1004071. doi: 10.1371/journal.ppat.1004071. eCollection 2014 Apr.

PMID:
24722454
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1.

Gallastegui E, Marshall B, Vidal D, Sanchez-Duffhues G, Collado JA, Alvarez-Fernández C, Luque N, Terme JM, Gatell JM, Sánchez-Palomino S, Muñoz E, Mestres J, Verdin E, Jordan A.

J Virol. 2012 Apr;86(7):3795-808. doi: 10.1128/JVI.05972-11. Epub 2012 Jan 18.

PMID:
22258251
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation.

Shan L, Deng K, Shroff NS, Durand CM, Rabi SA, Yang HC, Zhang H, Margolick JB, Blankson JN, Siliciano RF.

Immunity. 2012 Mar 23;36(3):491-501. doi: 10.1016/j.immuni.2012.01.014. Epub 2012 Mar 8.

PMID:
22406268
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Persistence of wild-type virus and lack of temporal structure in the latent reservoir for human immunodeficiency virus type 1 in pediatric patients with extensive antiretroviral exposure.

Ruff CT, Ray SC, Kwon P, Zinn R, Pendleton A, Hutton N, Ashworth R, Gange S, Quinn TC, Siliciano RF, Persaud D.

J Virol. 2002 Sep;76(18):9481-92.

PMID:
12186930
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.

Bullen CK, Laird GM, Durand CM, Siliciano JD, Siliciano RF.

Nat Med. 2014 Apr;20(4):425-9. doi: 10.1038/nm.3489. Epub 2014 Mar 23.

PMID:
24658076
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

A stable latent reservoir for HIV-1 in resting CD4(+) T lymphocytes in infected children.

Persaud D, Pierson T, Ruff C, Finzi D, Chadwick KR, Margolick JB, Ruff A, Hutton N, Ray S, Siliciano RF.

J Clin Invest. 2000 Apr;105(7):995-1003.

PMID:
10749578
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

A novel assay allows genotyping of the latent reservoir for human immunodeficiency virus type 1 in the resting CD4+ T cells of viremic patients.

Monie D, Simmons RP, Nettles RE, Kieffer TL, Zhou Y, Zhang H, Karmon S, Ingersoll R, Chadwick K, Zhang H, Margolick JB, Quinn TC, Ray SC, Wind-Rotolo M, Miller M, Persaud D, Siliciano RF.

J Virol. 2005 Apr;79(8):5185-202.

PMID:
15795302
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

From reactivation of latent HIV-1 to elimination of the latent reservoir: the presence of multiple barriers to viral eradication.

Shan L, Siliciano RF.

Bioessays. 2013 Jun;35(6):544-52. doi: 10.1002/bies.201200170. Epub 2013 Apr 24. Review.

PMID:
23613347
[PubMed - indexed for MEDLINE]
15.

Limits on replenishment of the resting CD4+ T cell reservoir for HIV in patients on HAART.

Sedaghat AR, Siliciano JD, Brennan TP, Wilke CO, Siliciano RF.

PLoS Pathog. 2007 Aug 31;3(8):e122.

PMID:
17784786
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

HIV DNA subspecies persist in both activated and resting memory CD4+ T cells during antiretroviral therapy.

Murray JM, Zaunders JJ, McBride KL, Xu Y, Bailey M, Suzuki K, Cooper DA, Emery S, Kelleher AD, Koelsch KK; PINT Study Team.

J Virol. 2014 Mar;88(6):3516-26. doi: 10.1128/JVI.03331-13. Epub 2014 Jan 8.

PMID:
24403590
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Recent developments in the search for a cure for HIV-1 infection: targeting the latent reservoir for HIV-1.

Siliciano JD, Siliciano RF.

J Allergy Clin Immunol. 2014 Jul;134(1):12-9. doi: 10.1016/j.jaci.2014.05.026. Epub 2014 Jun 26. Review.

PMID:
25117799
[PubMed - indexed for MEDLINE]
18.

Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy.

Finzi D, Hermankova M, Pierson T, Carruth LM, Buck C, Chaisson RE, Quinn TC, Chadwick K, Margolick J, Brookmeyer R, Gallant J, Markowitz M, Ho DD, Richman DD, Siliciano RF.

Science. 1997 Nov 14;278(5341):1295-300.

PMID:
9360927
[PubMed - indexed for MEDLINE]
Free Article
19.

The development of immune-modulating compounds to disrupt HIV latency.

Remoli AL, Marsili G, Battistini A, Sgarbanti M.

Cytokine Growth Factor Rev. 2012 Aug-Oct;23(4-5):159-72. doi: 10.1016/j.cytogfr.2012.05.003. Epub 2012 Jul 4. Review.

PMID:
22766356
[PubMed - indexed for MEDLINE]
20.

An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients.

Spina CA, Anderson J, Archin NM, Bosque A, Chan J, Famiglietti M, Greene WC, Kashuba A, Lewin SR, Margolis DM, Mau M, Ruelas D, Saleh S, Shirakawa K, Siliciano RF, Singhania A, Soto PC, Terry VH, Verdin E, Woelk C, Wooden S, Xing S, Planelles V.

PLoS Pathog. 2013;9(12):e1003834. doi: 10.1371/journal.ppat.1003834. Epub 2013 Dec 26.

PMID:
24385908
[PubMed - indexed for MEDLINE]
Free PMC Article
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