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Results: 1 to 20 of 103

1.

Direct detection of structurally resolved dynamics in a multiconformation receptor-ligand complex.

Carroll MJ, Gromova AV, Miller KR, Tang H, Wang XS, Tripathy A, Singleton SF, Collins EJ, Lee AL.

J Am Chem Soc. 2011 Apr 27;133(16):6422-8. doi: 10.1021/ja2005253. Epub 2011 Apr 6.

PMID:
21469679
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Automated identification of functional dynamic contact networks from X-ray crystallography.

van den Bedem H, Bhabha G, Yang K, Wright PE, Fraser JS.

Nat Methods. 2013 Sep;10(9):896-902. doi: 10.1038/nmeth.2592. Epub 2013 Aug 4.

PMID:
23913260
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Structure, dynamics, and catalytic function of dihydrofolate reductase.

Schnell JR, Dyson HJ, Wright PE.

Annu Rev Biophys Biomol Struct. 2004;33:119-40. Review.

PMID:
15139807
[PubMed - indexed for MEDLINE]
4.

Side chain conformational averaging in human dihydrofolate reductase.

Tuttle LM, Dyson HJ, Wright PE.

Biochemistry. 2014 Feb 25;53(7):1134-45. doi: 10.1021/bi4015314. Epub 2014 Feb 13.

PMID:
24498949
[PubMed - indexed for MEDLINE]
5.

Probing microsecond time scale dynamics in proteins by methyl (1)H Carr-Purcell-Meiboom-Gill relaxation dispersion NMR measurements. Application to activation of the signaling protein NtrC(r).

Otten R, Villali J, Kern D, Mulder FA.

J Am Chem Soc. 2010 Dec 1;132(47):17004-14. doi: 10.1021/ja107410x. Epub 2010 Nov 8.

PMID:
21058670
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Analysis of ligand binding and protein dynamics of human retinoid X receptor alpha ligand-binding domain by nuclear magnetic resonance.

Lu J, Cistola DP, Li E.

Biochemistry. 2006 Feb 14;45(6):1629-39.

PMID:
16460010
[PubMed - indexed for MEDLINE]
7.

Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR.

Fenwick RB, van den Bedem H, Fraser JS, Wright PE.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E445-54. doi: 10.1073/pnas.1323440111. Epub 2014 Jan 13.

PMID:
24474795
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The dynamic energy landscape of dihydrofolate reductase catalysis.

Boehr DD, McElheny D, Dyson HJ, Wright PE.

Science. 2006 Sep 15;313(5793):1638-42.

PMID:
16973882
[PubMed - indexed for MEDLINE]
Free Article
9.

Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands.

Boehr DD, McElheny D, Dyson HJ, Wright PE.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1373-8. doi: 10.1073/pnas.0914163107. Epub 2010 Jan 8.

PMID:
20080605
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Incorporating dynamics in E. coli dihydrofolate reductase enhances structure-based drug discovery.

Lerner MG, Bowman AL, Carlson HA.

J Chem Inf Model. 2007 Nov-Dec;47(6):2358-65. Epub 2007 Sep 18.

PMID:
17877338
[PubMed - indexed for MEDLINE]
11.

Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli.

Oyen D, Wechselberger R, Srinivasan V, Steyaert J, Barlow JN.

Biochim Biophys Acta. 2013 Oct;1834(10):2147-57. doi: 10.1016/j.bbapap.2013.07.010. Epub 2013 Jul 31.

PMID:
23911607
[PubMed - indexed for MEDLINE]
12.

Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+.

Cody V, Galitsky N, Rak D, Luft JR, Pangborn W, Queener SF.

Biochemistry. 1999 Apr 6;38(14):4303-12.

PMID:
10194348
[PubMed - indexed for MEDLINE]
13.

Characterization of enzyme motions by solution NMR relaxation dispersion.

Loria JP, Berlow RB, Watt ED.

Acc Chem Res. 2008 Feb;41(2):214-21. doi: 10.1021/ar700132n. Epub 2008 Feb 19. Review.

PMID:
18281945
[PubMed - indexed for MEDLINE]
14.

Nuclear magnetic resonance study of the role of M42 in the solution dynamics of Escherichia coli dihydrofolate reductase.

Mauldin RV, Lee AL.

Biochemistry. 2010 Mar 2;49(8):1606-15. doi: 10.1021/bi901798g.

PMID:
20073522
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Dynamic dysfunction in dihydrofolate reductase results from antifolate drug binding: modulation of dynamics within a structural state.

Mauldin RV, Carroll MJ, Lee AL.

Structure. 2009 Mar 11;17(3):386-94. doi: 10.1016/j.str.2009.01.005.

PMID:
19278653
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

1H/15N HSQC NMR studies of ligand carboxylate group interactions with arginine residues in complexes of brodimoprim analogues and Lactobacillus casei dihydrofolate reductase.

Morgan WD, Birdsall B, Nieto PM, Gargaro AR, Feeney J.

Biochemistry. 1999 Feb 16;38(7):2127-34.

PMID:
10026296
[PubMed - indexed for MEDLINE]
17.

Dynamics of the dihydrofolate reductase-folate complex: catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features.

Epstein DM, Benkovic SJ, Wright PE.

Biochemistry. 1995 Sep 5;34(35):11037-48.

PMID:
7669761
[PubMed - indexed for MEDLINE]
18.

In pursuit of virtual lead optimization: the role of the receptor structure and ensembles in accurate docking.

Bolstad ES, Anderson AC.

Proteins. 2008 Nov 15;73(3):566-80. doi: 10.1002/prot.22081.

PMID:
18473360
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The solution structure of Bacillus anthracis dihydrofolate reductase yields insight into the analysis of structure-activity relationships for novel inhibitors.

Beierlein JM, Deshmukh L, Frey KM, Vinogradova O, Anderson AC.

Biochemistry. 2009 May 19;48(19):4100-8. doi: 10.1021/bi802319w.

PMID:
19323450
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Effect of ligand binding on the flexibility of dihydrofolate reductase as revealed by compressibility.

Kamiyama T, Gekko K.

Biochim Biophys Acta. 2000 May 23;1478(2):257-66.

PMID:
10825537
[PubMed - indexed for MEDLINE]

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