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Items: 1 to 20 of 97

1.

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation.

Lam AP, Flozak AS, Russell S, Wei J, Jain M, Mutlu GM, Budinger GR, Feghali-Bostwick CA, Varga J, Gottardi CJ.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):915-22. doi: 10.1165/rcmb.2010-0113OC. Epub 2011 Mar 31.

2.

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells.

Wei J, Fang F, Lam AP, Sargent JL, Hamburg E, Hinchcliff ME, Gottardi CJ, Atit R, Whitfield ML, Varga J.

Arthritis Rheum. 2012 Aug;64(8):2734-45. doi: 10.1002/art.34424.

3.

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis.

Beyer C, Schramm A, Akhmetshina A, Dees C, Kireva T, Gelse K, Sonnylal S, de Crombrugghe B, Taketo MM, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2012 May;71(5):761-7. doi: 10.1136/annrheumdis-2011-200568. Epub 2012 Feb 10.

4.

Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease.

Baarsma HA, Spanjer AI, Haitsma G, Engelbertink LH, Meurs H, Jonker MR, Timens W, Postma DS, Kerstjens HA, Gosens R.

PLoS One. 2011;6(9):e25450. doi: 10.1371/journal.pone.0025450. Epub 2011 Sep 30.

5.

Functional Wnt signaling is increased in idiopathic pulmonary fibrosis.

Königshoff M, Balsara N, Pfaff EM, Kramer M, Chrobak I, Seeger W, Eickelberg O.

PLoS One. 2008 May 14;3(5):e2142. doi: 10.1371/journal.pone.0002142.

6.

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?

Wei J, Melichian D, Komura K, Hinchcliff M, Lam AP, Lafyatis R, Gottardi CJ, MacDougald OA, Varga J.

Arthritis Rheum. 2011 Jun;63(6):1707-17. doi: 10.1002/art.30312.

8.

Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis.

Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA.

J Clin Invest. 2009 Jan;119(1):213-24. doi: 10.1172/JCI36940. Epub 2008 Dec 22.

9.

Blockade of the Wnt/β-catenin pathway attenuates bleomycin-induced pulmonary fibrosis.

Kim TH, Kim SH, Seo JY, Chung H, Kwak HJ, Lee SK, Yoon HJ, Shin DH, Park SS, Sohn JW.

Tohoku J Exp Med. 2011;223(1):45-54.

10.

Absence of Thy-1 results in TGF-β induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts.

Ramírez G, Hagood JS, Sanders Y, Ramírez R, Becerril C, Segura L, Barrera L, Selman M, Pardo A.

Lab Invest. 2011 Aug;91(8):1206-18. doi: 10.1038/labinvest.2011.80. Epub 2011 May 16.

12.

Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process.

Wang C, Dai J, Sun Z, Shi C, Cao H, Chen X, Gu S, Li Z, Qian W, Han X.

Exp Cell Res. 2015 Feb 1;331(1):115-22. doi: 10.1016/j.yexcr.2014.10.023. Epub 2014 Nov 5.

PMID:
25445788
13.

Inhibition of Wnt/β-catenin signaling promotes epithelial differentiation of mesenchymal stem cells and repairs bleomycin-induced lung injury.

Wang C, Zhu H, Sun Z, Xiang Z, Ge Y, Ni C, Luo Z, Qian W, Han X.

Am J Physiol Cell Physiol. 2014 Aug 1;307(3):C234-44. doi: 10.1152/ajpcell.00366.2013. Epub 2014 Jun 4.

14.

Inhibition of Wnt/β-catenin signaling promotes engraftment of mesenchymal stem cells to repair lung injury.

Sun Z, Gong X, Zhu H, Wang C, Xu X, Cui D, Qian W, Han X.

J Cell Physiol. 2014 Feb;229(2):213-24. doi: 10.1002/jcp.24436.

PMID:
23881674
15.

Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts.

Bogatkevich GS, Ludwicka-Bradley A, Silver RM.

Arthritis Rheum. 2009 Nov;60(11):3455-64. doi: 10.1002/art.24935.

16.

Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs.

Villar J, Cabrera NE, Valladares F, Casula M, Flores C, Blanch L, Quilez ME, Santana-Rodríguez N, Kacmarek RM, Slutsky AS.

PLoS One. 2011;6(9):e23914. doi: 10.1371/journal.pone.0023914. Epub 2011 Sep 15.

17.

Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis.

Zhou Y, Lee JY, Lee CM, Cho WK, Kang MJ, Koff JL, Yoon PO, Chae J, Park HO, Elias JA, Lee CG.

J Biol Chem. 2012 Dec 7;287(50):41991-2000. doi: 10.1074/jbc.M112.356824. Epub 2012 Oct 19.

18.

Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis.

Zhang HY, Gharaee-Kermani M, Zhang K, Karmiol S, Phan SH.

Am J Pathol. 1996 Feb;148(2):527-37.

19.
20.

Low α(2)β(1) integrin function enhances the proliferation of fibroblasts from patients with idiopathic pulmonary fibrosis by activation of the β-catenin pathway.

Xia H, Seeman J, Hong J, Hergert P, Bodem V, Jessurun J, Smith K, Nho R, Kahm J, Gaillard P, Henke C.

Am J Pathol. 2012 Jul;181(1):222-33. doi: 10.1016/j.ajpath.2012.03.034. Epub 2012 May 27.

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