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Altered expression of renal aquaporins and α-adducin polymorphisms may contribute to the establishment of salt-sensitive hypertension.

Procino G, Romano F, Torielli L, Ferrari P, Bianchi G, Svelto M, Valenti G.

Am J Hypertens. 2011 Jul;24(7):822-8. doi: 10.1038/ajh.2011.47. Epub 2011 Mar 31.


alpha-Adducin mutations increase Na/K pump activity in renal cells by affecting constitutive endocytosis: implications for tubular Na reabsorption.

Torielli L, Tivodar S, Montella RC, Iacone R, Padoani G, Tarsini P, Russo O, Sarnataro D, Strazzullo P, Ferrari P, Bianchi G, Zurzolo C.

Am J Physiol Renal Physiol. 2008 Aug;295(2):F478-87. doi: 10.1152/ajprenal.90226.2008. Epub 2008 Jun 4.


Adducin in essential hypertension.

Manunta P, Barlassina C, Bianchi G.

FEBS Lett. 1998 Jun 23;430(1-2):41-4. Review.


Alpha-adducin polymorphisms and renal sodium handling in essential hypertensive patients.

Manunta P, Cusi D, Barlassina C, Righetti M, Lanzani C, D'Amico M, Buzzi L, Citterio L, Stella P, Rivera R, Bianchi G.

Kidney Int. 1998 Jun;53(6):1471-8.


Genetics of renal mechanisms of primary hypertension: the role of adducin.

Barlassina C, Citterio L, Bernardi L, Buzzi L, D'Amico M, Sciarrone T, Bianchi G.

J Hypertens. 1997 Dec;15(12 Pt 2):1567-71. Review.


Evidence for an interaction between adducin and Na(+)-K(+)-ATPase: relation to genetic hypertension.

Ferrandi M, Salardi S, Tripodi G, Barassi P, Rivera R, Manunta P, Goldshleger R, Ferrari P, Bianchi G, Karlish SJ.

Am J Physiol. 1999 Oct;277(4 Pt 2):H1338-49.


Blocking the salt-inducible kinase 1 network prevents the increases in cell sodium transport caused by a hypertension-linked mutation in human alpha-adducin.

Stenström K, Takemori H, Bianchi G, Katz AI, Bertorello AM.

J Hypertens. 2009 Dec;27(12):2452-7. doi: 10.1097/HJH.0b013e328330cf15.


Renal Na,K-ATPase in genetic hypertension.

Ferrandi M, Tripodi G, Salardi S, Florio M, Modica R, Barassi P, Parenti P, Shainskaya A, Karlish S, Bianchi G, Ferrari P.

Hypertension. 1996 Dec;28(6):1018-25.


PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension.

Ferrari P, Ferrandi M, Tripodi G, Torielli L, Padoani G, Minotti E, Melloni P, Bianchi G.

J Pharmacol Exp Ther. 1999 Mar;288(3):1074-83.


Genetic aspects of ion transport systems in hypertension.

Bianchi G, Ferrari P, Cusi D, Tripodi G, Barber B.

J Hypertens Suppl. 1990 Dec;8(7):S213-8. Review.


Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium.

Efendiev R, Krmar RT, Ogimoto G, Zwiller J, Tripodi G, Katz AI, Bianchi G, Pedemonte CH, Bertorello AM.

Circ Res. 2004 Nov 26;95(11):1100-8. Epub 2004 Nov 4.


Upregulation of apical sodium-chloride cotransporter and basolateral chloride channels is responsible for the maintenance of salt-sensitive hypertension.

Capasso G, Rizzo M, Garavaglia ML, Trepiccione F, Zacchia M, Mugione A, Ferrari P, Paulmichl M, Lang F, Loffing J, Carrel M, Damiano S, Wagner CA, Bianchi G, Meyer G.

Am J Physiol Renal Physiol. 2008 Aug;295(2):F556-67. doi: 10.1152/ajprenal.00340.2007. Epub 2008 May 14.


Tissue-specific modulation of beta-adducin transcripts in Milan hypertensive rats.

Tripodi G, Modica R, Reina C, Bianchi G.

Biochem Biophys Res Commun. 2003 Mar 28;303(1):230-7.


alpha-Adducin 460Trp allele is associated with erythrocyte Na transport rate in North Sardinian primary hypertensives.

Glorioso N, Filigheddu F, Cusi D, Troffa C, Conti M, Natalizio M, Argiolas G, Barlassina C, Bianchi G.

Hypertension. 2002 Feb;39(2 Pt 2):357-62.


Characterization of erythrocyte adducin from the Milan hypertensive strain of rats.

Salardi S, Modica R, Ferrandi M, Ferrari P, Torielli L, Bianchi G.

J Hypertens Suppl. 1988 Dec;6(4):S196-8.


Two point mutations within the adducin genes are involved in blood pressure variation.

Bianchi G, Tripodi G, Casari G, Salardi S, Barber BR, Garcia R, Leoni P, Torielli L, Cusi D, Ferrandi M, et al.

Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3999-4003.


Downregulation of renal aquaporins in response to unilateral ureteral obstruction.

Li C, Wang W, Knepper MA, Nielsen S, Frøkiaer J.

Am J Physiol Renal Physiol. 2003 May;284(5):F1066-79. Epub 2003 Jan 7.


Genetic mapping of blood pressure quantitative trait loci in Milan hypertensive rats.

Zagato L, Modica R, Florio M, Torielli L, Bihoreau MT, Bianchi G, Tripodi G.

Hypertension. 2000 Nov;36(5):734-9.


Hypertension-linked mutation of α-adducin increases CFTR surface expression and activity in HEK and cultured rat distal convoluted tubule cells.

Mondini A, Sassone F, Civello DA, Garavaglia ML, Bazzini C, Rodighiero S, Vezzoli V, Conti F, Torielli L, Capasso G, Paulmichl M, Meyer G.

PLoS One. 2012;7(12):e52014. doi: 10.1371/journal.pone.0052014. Epub 2012 Dec 21.

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