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Similar articles for PubMed (Select 21450809)


Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies.

Morris EP, Rivera-Calzada A, da Fonseca PC, Llorca O, Pearl LH, Spagnolo L.

Nucleic Acids Res. 2011 Jul;39(13):5757-67. doi: 10.1093/nar/gkr146. Epub 2011 Mar 30.


The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation.

Merkle D, Douglas P, Moorhead GB, Leonenko Z, Yu Y, Cramb D, Bazett-Jones DP, Lees-Miller SP.

Biochemistry. 2002 Oct 22;41(42):12706-14.


DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.

Douglas P, Gupta S, Morrice N, Meek K, Lees-Miller SP.

DNA Repair (Amst). 2005 Aug 15;4(9):1006-18.


Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.

Ding Q, Reddy YV, Wang W, Woods T, Douglas P, Ramsden DA, Lees-Miller SP, Meek K.

Mol Cell Biol. 2003 Aug;23(16):5836-48.


Analysis of DNA-dependent protein kinase-mediated DNA end joining by two-photon fluorescence cross-correlation spectroscopy.

Merkle D, Block WD, Yu Y, Lees-Miller SP, Cramb DT.

Biochemistry. 2006 Apr 4;45(13):4164-72.


Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.

Reddy YV, Ding Q, Lees-Miller SP, Meek K, Ramsden DA.

J Biol Chem. 2004 Sep 17;279(38):39408-13. Epub 2004 Jul 15.


Visualization of a DNA-PK/PARP1 complex.

Spagnolo L, Barbeau J, Curtin NJ, Morris EP, Pearl LH.

Nucleic Acids Res. 2012 May;40(9):4168-77. doi: 10.1093/nar/gkr1231. Epub 2012 Jan 5.


A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation.

Dobbs TA, Tainer JA, Lees-Miller SP.

DNA Repair (Amst). 2010 Dec 10;9(12):1307-14. doi: 10.1016/j.dnarep.2010.09.019. Epub 2010 Oct 28. Review.


Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends.

Block WD, Yu Y, Merkle D, Gifford JL, Ding Q, Meek K, Lees-Miller SP.

Nucleic Acids Res. 2004 Aug 16;32(14):4351-7. Print 2004.


Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage.

Olsen BB, Wang SY, Svenstrup TH, Chen BP, Guerra B.

BMC Mol Biol. 2012 Mar 9;13:7. doi: 10.1186/1471-2199-13-7.


Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks.

Uematsu N, Weterings E, Yano K, Morotomi-Yano K, Jakob B, Taucher-Scholz G, Mari PO, van Gent DC, Chen BP, Chen DJ.

J Cell Biol. 2007 Apr 23;177(2):219-29. Epub 2007 Apr 16.


Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.

Chan DW, Chen BP, Prithivirajsingh S, Kurimasa A, Story MD, Qin J, Chen DJ.

Genes Dev. 2002 Sep 15;16(18):2333-8.


Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair.

Fukushima T, Takata M, Morrison C, Araki R, Fujimori A, Abe M, Tatsumi K, Jasin M, Dhar PK, Sonoda E, Chiba T, Takeda S.

J Biol Chem. 2001 Nov 30;276(48):44413-8. Epub 2001 Sep 27.


DNA-PK autophosphorylation facilitates Artemis endonuclease activity.

Goodarzi AA, Yu Y, Riballo E, Douglas P, Walker SA, Ye R, Härer C, Marchetti C, Morrice N, Jeggo PA, Lees-Miller SP.

EMBO J. 2006 Aug 23;25(16):3880-9. Epub 2006 Jul 27.


Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

Chen BP, Chan DW, Kobayashi J, Burma S, Asaithamby A, Morotomi-Yano K, Botvinick E, Qin J, Chen DJ.

J Biol Chem. 2005 Apr 15;280(15):14709-15. Epub 2005 Jan 26.

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