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Items: 1 to 20 of 77

1.

Toll-like receptor 4 inhibitor TAK-242 attenuates acute kidney injury in endotoxemic sheep.

Fenhammar J, Rundgren M, Forestier J, Kalman S, Eriksson S, Frithiof R.

Anesthesiology. 2011 May;114(5):1130-7. doi: 10.1097/ALN.0b013e31820b8b44.

PMID:
21394006
2.

Effect of Toll-like receptor 4 inhibitor on LPS-induced lung injury.

Seki H, Tasaka S, Fukunaga K, Shiraishi Y, Moriyama K, Miyamoto K, Nakano Y, Matsunaga N, Takashima K, Matsumoto T, Ii M, Ishizaka A, Takeda J.

Inflamm Res. 2010 Oct;59(10):837-45. doi: 10.1007/s00011-010-0195-3. Epub 2010 Apr 13.

PMID:
20387088
3.

TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules.

Matsunaga N, Tsuchimori N, Matsumoto T, Ii M.

Mol Pharmacol. 2011 Jan;79(1):34-41. doi: 10.1124/mol.110.068064. Epub 2010 Sep 29.

4.

The novel selective toll-like receptor 4 signal transduction inhibitor tak-242 prevents endotoxaemia in conscious Guinea-pigs.

Kuno M, Nemoto K, Ninomiya N, Inagaki E, Kubota M, Matsumoto T, Yokota H.

Clin Exp Pharmacol Physiol. 2009 May;36(5-6):589-93. doi: 10.1111/j.1440-1681.2008.05121.x. Epub 2008 Oct 27.

PMID:
19673945
5.
6.

Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure.

Wang W, Jittikanont S, Falk SA, Li P, Feng L, Gengaro PE, Poole BD, Bowler RP, Day BJ, Crapo JD, Schrier RW.

Am J Physiol Renal Physiol. 2003 Mar;284(3):F532-7.

7.

Renal effects of treatment with a TLR4 inhibitor in conscious septic sheep.

Fenhammar J, Rundgren M, Hultenby K, Forestier J, Taavo M, Kenne E, Weitzberg E, Eriksson S, Ozenci V, Wernerson A, Frithiof R.

Crit Care. 2014 Sep 3;18(5):488. doi: 10.1186/s13054-014-0488-y.

8.

Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia.

Baumgarten G, Knuefermann P, Schuhmacher G, Vervölgyi V, von Rappard J, Dreiner U, Fink K, Djoufack C, Hoeft A, Grohé C, Knowlton AA, Meyer R.

Shock. 2006 Jan;25(1):43-9.

PMID:
16369185
9.

TAK-242, a Toll-Like Receptor 4 Antagonist, Protects against Aldosterone-Induced Cardiac and Renal Injury.

Zhang Y, Peng W, Ao X, Dai H, Yuan L, Huang X, Zhou Q.

PLoS One. 2015 Nov 10;10(11):e0142456. doi: 10.1371/journal.pone.0142456. eCollection 2015.

10.

Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia.

Pastor CM, Pugin J, Kwak B, Chanson M, Mach F, Hadengue A, Frossard JL.

Crit Care Med. 2004 Aug;32(8):1759-63.

PMID:
15286555
11.
12.

Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model.

Takashima K, Matsunaga N, Yoshimatsu M, Hazeki K, Kaisho T, Uekata M, Hazeki O, Akira S, Iizawa Y, Ii M.

Br J Pharmacol. 2009 Aug;157(7):1250-62. doi: 10.1111/j.1476-5381.2009.00297.x. Epub 2009 Jun 25.

13.

Glycine attenuates endotoxin-induced liver injury by downregulating TLR4 signaling in Kupffer cells.

Xu FL, You HB, Li XH, Chen XF, Liu ZJ, Gong JP.

Am J Surg. 2008 Jul;196(1):139-48. doi: 10.1016/j.amjsurg.2007.09.045.

PMID:
18565339
14.

Improvement of renal dysfunction in dogs with endotoxemia by a nonselective endothelin receptor antagonist.

Mitaka C, Hirata Y, Yokoyama K, Nagura T, Tsunoda Y, Amaha K.

Crit Care Med. 1999 Jan;27(1):146-53.

PMID:
9934909
15.

Protective effect of renal denervation on normotensive endotoxemia-induced acute renal failure in mice.

Wang W, Falk SA, Jittikanont S, Gengaro PE, Edelstein CL, Schrier RW.

Am J Physiol Renal Physiol. 2002 Sep;283(3):F583-7.

16.
17.

Salvage effect of E5564, Toll-like receptor 4 antagonist on d-galactosamine and lipopolysaccharide-induced acute liver failure in rats.

Kitazawa T, Tsujimoto T, Kawaratani H, Fukui H.

J Gastroenterol Hepatol. 2010 May;25(5):1009-12. doi: 10.1111/j.1440-1746.2009.06145.x.

PMID:
20546456
18.

Is there a role for cardiomyocyte toll-like receptor 4 in endotoxemia?

Tavener SA, Kubes P.

Trends Cardiovasc Med. 2005 Jul;15(5):153-7. Review.

PMID:
16165010
19.

Protective effects of Toll-like receptor 4 inhibitor eritoran on renal ischemia-reperfusion injury.

Liu M, Gu M, Xu D, Lv Q, Zhang W, Wu Y.

Transplant Proc. 2010 Jun;42(5):1539-44. doi: 10.1016/j.transproceed.2010.03.133.

PMID:
20620471
20.

Leukocyte toll-like receptor expression in end-stage kidney disease.

Gollapudi P, Yoon JW, Gollapudi S, Pahl MV, Vaziri ND.

Am J Nephrol. 2010;31(3):247-54. doi: 10.1159/000276764. Epub 2010 Jan 15.

PMID:
20090311
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