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Results: 1 to 20 of 122

1.

Structure of an agonist-bound human A2A adenosine receptor.

Xu F, Wu H, Katritch V, Han GW, Jacobson KA, Gao ZG, Cherezov V, Stevens RC.

Science. 2011 Apr 15;332(6027):322-7. doi: 10.1126/science.1202793. Epub 2011 Mar 10.

PMID:
21393508
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation.

Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG.

Nature. 2011 May 18;474(7352):521-5. doi: 10.1038/nature10136.

PMID:
21593763
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor.

Deflorian F, Kumar TS, Phan K, Gao ZG, Xu F, Wu H, Katritch V, Stevens RC, Jacobson KA.

J Med Chem. 2012 Jan 12;55(1):538-52. doi: 10.1021/jm201461q. Epub 2011 Dec 12.

PMID:
22104008
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Structural basis for allosteric regulation of GPCRs by sodium ions.

Liu W, Chun E, Thompson AA, Chubukov P, Xu F, Katritch V, Han GW, Roth CB, Heitman LH, IJzerman AP, Cherezov V, Stevens RC.

Science. 2012 Jul 13;337(6091):232-6. doi: 10.1126/science.1219218.

PMID:
22798613
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine.

Doré AS, Robertson N, Errey JC, Ng I, Hollenstein K, Tehan B, Hurrell E, Bennett K, Congreve M, Magnani F, Tate CG, Weir M, Marshall FH.

Structure. 2011 Sep 7;19(9):1283-93. doi: 10.1016/j.str.2011.06.014.

PMID:
21885291
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

[Structure of the adenosine-bound conformation of the human adenosine A(2A) receptor].

Lebon G, Tate CG.

Med Sci (Paris). 2011 Nov;27(11):926-8. doi: 10.1051/medsci/20112711004. Epub 2011 Nov 30. French. No abstract available.

PMID:
22130015
[PubMed - indexed for MEDLINE]
Free Article
7.

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.

Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC.

Science. 2008 Nov 21;322(5905):1211-7. doi: 10.1126/science.1164772. Epub 2008 Oct 2.

PMID:
18832607
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues.

Jaakola VP, Lane JR, Lin JY, Katritch V, Ijzerman AP, Stevens RC.

J Biol Chem. 2010 Apr 23;285(17):13032-44. doi: 10.1074/jbc.M109.096974. Epub 2010 Feb 10.

PMID:
20147292
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Structural insights into agonist-induced activation of G-protein-coupled receptors.

Deupi X, Standfuss J.

Curr Opin Struct Biol. 2011 Aug;21(4):541-51. doi: 10.1016/j.sbi.2011.06.002. Epub 2011 Jun 30. Review.

PMID:
21723721
[PubMed - indexed for MEDLINE]
10.

Agonist-bound structures of G protein-coupled receptors.

Lebon G, Warne T, Tate CG.

Curr Opin Struct Biol. 2012 Aug;22(4):482-90. doi: 10.1016/j.sbi.2012.03.007. Epub 2012 Apr 3. Review.

PMID:
22480933
[PubMed - indexed for MEDLINE]
11.

Agonist dynamics and conformational selection during microsecond simulations of the A(2A) adenosine receptor.

Lee JY, Lyman E.

Biophys J. 2012 May 2;102(9):2114-20. doi: 10.1016/j.bpj.2012.03.061.

PMID:
22824275
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Thermostabilisation of an agonist-bound conformation of the human adenosine A(2A) receptor.

Lebon G, Bennett K, Jazayeri A, Tate CG.

J Mol Biol. 2011 Jun 10;409(3):298-310. doi: 10.1016/j.jmb.2011.03.075. Epub 2011 Apr 9.

PMID:
21501622
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Evaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure.

Ivanov AA, Barak D, Jacobson KA.

J Med Chem. 2009 May 28;52(10):3284-92. doi: 10.1021/jm801533x.

PMID:
19402631
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor.

Kim SK, Gao ZG, Jeong LS, Jacobson KA.

J Mol Graph Model. 2006 Dec;25(4):562-77. Epub 2006 May 9.

PMID:
16793299
[PubMed - indexed for MEDLINE]
15.

Common and distinct mechanisms of activation of rhodopsin and other G protein-coupled receptors.

Nakamura S, Itabashi T, Ogawa D, Okada T.

Sci Rep. 2013;3:1844. doi: 10.1038/srep01844.

PMID:
23677071
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands.

El-Tayeb A, Gollos S.

Bioorg Med Chem. 2013 Jan 15;21(2):436-47. doi: 10.1016/j.bmc.2012.11.021. Epub 2012 Nov 27.

PMID:
23245803
[PubMed - indexed for MEDLINE]
17.

G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody.

Hino T, Arakawa T, Iwanari H, Yurugi-Kobayashi T, Ikeda-Suno C, Nakada-Nakura Y, Kusano-Arai O, Weyand S, Shimamura T, Nomura N, Cameron AD, Kobayashi T, Hamakubo T, Iwata S, Murata T.

Nature. 2012 Jan 29;482(7384):237-40. doi: 10.1038/nature10750.

PMID:
22286059
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Novel adenosine A(2A) receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A(2A) receptor antagonists for extending into extracellular space.

Jörg M, Shonberg J, Mak FS, Miller ND, Yuriev E, Scammells PJ, Capuano B.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3427-33. doi: 10.1016/j.bmcl.2013.03.070. Epub 2013 Apr 2.

PMID:
23602401
[PubMed - indexed for MEDLINE]
19.

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.

Michino M, Abola E; GPCR Dock 2008 participants, Brooks CL 3rd, Dixon JS, Moult J, Stevens RC.

Nat Rev Drug Discov. 2009 Jun;8(6):455-63. doi: 10.1038/nrd2877.

PMID:
19461661
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

On the existence of a possible A2A-D2-β-Arrestin2 complex: A2A agonist modulation of D2 agonist-induced β-arrestin2 recruitment.

Borroto-Escuela DO, Romero-Fernandez W, Tarakanov AO, Ciruela F, Agnati LF, Fuxe K.

J Mol Biol. 2011 Mar 11;406(5):687-99. doi: 10.1016/j.jmb.2011.01.022. Epub 2011 Jan 20.

PMID:
21256133
[PubMed - indexed for MEDLINE]

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