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Items: 1 to 20 of 107

1.

Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization.

Ardestani A, Sauter NS, Paroni F, Dharmadhikari G, Cho JH, Lupi R, Marchetti P, Oberholzer J, Conte JK, Maedler K.

J Biol Chem. 2011 May 13;286(19):17144-55. doi: 10.1074/jbc.M110.210526. Epub 2011 Mar 10. Retraction in: Ardestani A, Sauter NS, Paroni F, Dharmadhikari G, Cho JH, Lupi R, Marchetti P, Oberholzer J, Kerr Conte J, Maedler K. J Biol Chem. 2015 Nov 13;290(46):27532.

2.

PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation.

Guo L, Inada A, Aguayo-Mazzucato C, Hollister-Lock J, Fujitani Y, Weir GC, Wright CV, Sharma A, Bonner-Weir S.

Diabetes. 2013 Oct;62(10):3459-68. doi: 10.2337/db12-1833. Epub 2013 Jun 17.

3.

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.

Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH 3rd, Wright CV, White MF, Arden KC, Accili D.

J Clin Invest. 2002 Dec;110(12):1839-47.

4.

Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice.

Claiborn KC, Sachdeva MM, Cannon CE, Groff DN, Singer JD, Stoffers DA.

J Clin Invest. 2010 Oct;120(10):3713-21. doi: 10.1172/JCI40440. Epub 2010 Sep 1.

5.

Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6).

Meur G, Qian Q, da Silva Xavier G, Pullen TJ, Tsuboi T, McKinnon C, Fletcher L, Tavaré JM, Hughes S, Johnson P, Rutter GA.

J Biol Chem. 2011 Apr 15;286(15):13647-56. doi: 10.1074/jbc.M110.204248. Epub 2011 Feb 18.

6.

Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice.

Kajiyama H, Hamazaki TS, Tokuhara M, Masui S, Okabayashi K, Ohnuma K, Yabe S, Yasuda K, Ishiura S, Okochi H, Asashima M.

Int J Dev Biol. 2010;54(4):699-705. doi: 10.1387/ijdb.092953hk.

7.

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.

Sachdeva MM, Claiborn KC, Khoo C, Yang J, Groff DN, Mirmira RG, Stoffers DA.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19090-5. doi: 10.1073/pnas.0904849106. Epub 2009 Oct 23.

8.

Maintenance of Pdx1 mRNA translation in islet β-cells during the unfolded protein response.

Templin AT, Maier B, Tersey SA, Hatanaka M, Mirmira RG.

Mol Endocrinol. 2014 Nov;28(11):1820-30. doi: 10.1210/me.2014-1157. Epub 2014 Sep 24.

9.

Pdx1 restores beta cell function in Irs2 knockout mice.

Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy MR, White MF.

J Clin Invest. 2002 May;109(9):1193-201.

10.

Tshz1 Regulates Pancreatic β-Cell Maturation.

Raum JC, Soleimanpour SA, Groff DN, Coré N, Fasano L, Garratt AN, Dai C, Powers AC, Stoffers DA.

Diabetes. 2015 Aug;64(8):2905-14. doi: 10.2337/db14-1443. Epub 2015 Apr 27.

11.

Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.

Maganti AV, Maier B, Tersey SA, Sampley ML, Mosley AL, Özcan S, Pachaiyappan B, Woster PM, Hunter CS, Stein R, Mirmira RG.

J Biol Chem. 2015 Apr 10;290(15):9812-22. doi: 10.1074/jbc.M114.616219. Epub 2015 Feb 24.

12.

Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms.

Boucher MJ, Selander L, Carlsson L, Edlund H.

J Biol Chem. 2006 Mar 10;281(10):6395-403. Epub 2006 Jan 11.

13.

Expression of Pdx1 mediates differentiation from mesenchymal stem cells into insulin-producing cells.

Yuan H, Li J, Xin N, Zhao Z, Qin G.

Mol Biol Rep. 2010 Dec;37(8):4023-31. doi: 10.1007/s11033-010-0061-y. Epub 2010 Mar 21.

PMID:
20306305
14.

Glial cell line-derived neurotrophic factor enhances neurogenin3 gene expression and beta-cell proliferation in the developing mouse pancreas.

Mwangi SM, Usta Y, Raja SM, Anitha M, Chandrasekharan B, Parsadanian A, Sitaraman SV, Srinivasan S.

Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G283-92. doi: 10.1152/ajpgi.00096.2010. Epub 2010 May 6.

15.

Regulation of postnatal pancreatic Pdx1 and downstream target genes after gestational exposure to protein restriction in rats.

Abuzgaia AM, Hardy DB, Arany E.

Reproduction. 2015 Mar;149(3):293-303. doi: 10.1530/REP-14-0245. Epub 2014 Dec 2.

16.

Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation.

Frogne T, Sylvestersen KB, Kubicek S, Nielsen ML, Hecksher-Sørensen J.

PLoS One. 2012;7(4):e35233. doi: 10.1371/journal.pone.0035233. Epub 2012 Apr 11.

17.

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J, Pattou F, Halban PA, Weir GC, Donath MY.

J Clin Endocrinol Metab. 2008 Oct;93(10):4065-74. doi: 10.1210/jc.2008-0396. Epub 2008 Jul 29.

18.

Requirement for Pdx1 in specification of latent endocrine progenitors in zebrafish.

Kimmel RA, Onder L, Wilfinger A, Ellertsdottir E, Meyer D.

BMC Biol. 2011 Oct 31;9:75. doi: 10.1186/1741-7007-9-75.

19.

Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation.

Fujimoto K, Hanson PT, Tran H, Ford EL, Han Z, Johnson JD, Schmidt RE, Green KG, Wice BM, Polonsky KS.

J Biol Chem. 2009 Oct 2;284(40):27664-73. doi: 10.1074/jbc.M109.041616. Epub 2009 Aug 4.

20.

Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization.

An R, da Silva Xavier G, Semplici F, Vakhshouri S, Hao HX, Rutter J, Pagano MA, Meggio F, Pinna LA, Rutter GA.

Biochem Biophys Res Commun. 2010 Aug 20;399(2):155-61. doi: 10.1016/j.bbrc.2010.07.035. Epub 2010 Jul 15.

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