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Results: 1 to 20 of 102

1.

Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger.

Insel PA, Zhang L, Murray F, Yokouchi H, Zambon AC.

Acta Physiol (Oxf). 2012 Feb;204(2):277-87. doi: 10.1111/j.1748-1716.2011.02273.x. Epub 2011 May 26. Review.

PMID:
21385327
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation.

Wang Z, Dillon TJ, Pokala V, Mishra S, Labudda K, Hunter B, Stork PJ.

Mol Cell Biol. 2006 Mar;26(6):2130-45.

PMID:
16507992
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Increased expression of the pro-apoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells.

Zambon AC, Wilderman A, Ho A, Insel PA.

J Biol Chem. 2011 Sep 23;286(38):33260-7. doi: 10.1074/jbc.M111.268979. Epub 2011 Aug 1.

PMID:
21808067
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation.

Mei FC, Qiao J, Tsygankova OM, Meinkoth JL, Quilliam LA, Cheng X.

J Biol Chem. 2002 Mar 29;277(13):11497-504. Epub 2002 Jan 18.

PMID:
11801596
[PubMed - indexed for MEDLINE]
Free Article
5.

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor.

Rangarajan S, Enserink JM, Kuiperij HB, de Rooij J, Price LS, Schwede F, Bos JL.

J Cell Biol. 2003 Feb 17;160(4):487-93. Epub 2003 Feb 10.

PMID:
12578910
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways.

Li J, O'Connor KL, Cheng X, Mei FC, Uchida T, Townsend CM Jr, Evers BM.

Mol Endocrinol. 2007 Jan;21(1):159-71. Epub 2006 Oct 26.

PMID:
17068197
[PubMed - indexed for MEDLINE]
7.

Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis.

Hochbaum D, Hong K, Barila G, Ribeiro-Neto F, Altschuler DL.

J Biol Chem. 2008 Feb 22;283(8):4464-8. Epub 2007 Dec 6.

PMID:
18063584
[PubMed - indexed for MEDLINE]
Free Article
8.

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.

de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL.

Nature. 1998 Dec 3;396(6710):474-7.

PMID:
9853756
[PubMed - indexed for MEDLINE]
9.

Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes.

Petersen RK, Madsen L, Pedersen LM, Hallenborg P, Hagland H, Viste K, Døskeland SO, Kristiansen K.

Mol Cell Biol. 2008 Jun;28(11):3804-16. doi: 10.1128/MCB.00709-07. Epub 2008 Apr 7.

PMID:
18391018
[PubMed - indexed for MEDLINE]
Free PMC Article
10.
12.

Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states.

Mazhab-Jafari MT, Das R, Fotheringham SA, SilDas S, Chowdhury S, Melacini G.

J Am Chem Soc. 2007 Nov 21;129(46):14482-92. Epub 2007 Oct 31.

PMID:
17973384
[PubMed - indexed for MEDLINE]
13.

PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways.

Kwak HJ, Park KM, Choi HE, Chung KS, Lim HJ, Park HY.

Cell Signal. 2008 May;20(5):803-14. doi: 10.1016/j.cellsig.2007.12.011. Epub 2007 Dec 28.

PMID:
18276108
[PubMed - indexed for MEDLINE]
14.

Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.

Chepurny OG, Leech CA, Kelley GG, Dzhura I, Dzhura E, Li X, Rindler MJ, Schwede F, Genieser HG, Holz GG.

J Biol Chem. 2009 Apr 17;284(16):10728-36. doi: 10.1074/jbc.M900166200. Epub 2009 Feb 25.

PMID:
19244230
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis.

Tiwari S, Felekkis K, Moon EY, Flies A, Sherr DH, Lerner A.

Blood. 2004 Apr 1;103(7):2661-7. Epub 2003 Nov 13.

PMID:
14615375
[PubMed - indexed for MEDLINE]
Free Article
16.

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

Enserink JM, Christensen AE, de Rooij J, van Triest M, Schwede F, Genieser HG, Døskeland SO, Blank JL, Bos JL.

Nat Cell Biol. 2002 Nov;4(11):901-6.

PMID:
12402047
[PubMed - indexed for MEDLINE]
17.

The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells.

Zhang L, Insel PA.

J Biol Chem. 2004 May 14;279(20):20858-65. Epub 2004 Mar 2.

PMID:
14996839
[PubMed - indexed for MEDLINE]
Free Article
18.

Microtubule-associated proteins (MAPs) regulate cAMP signalling through exchange protein directly activated by cAMP (EPAC).

Yarwood SJ.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1327-9. Review.

PMID:
16246110
[PubMed - indexed for MEDLINE]
19.

A novel Epac-Rap-PP2A signaling module controls cAMP-dependent Akt regulation.

Hong K, Lou L, Gupta S, Ribeiro-Neto F, Altschuler DL.

J Biol Chem. 2008 Aug 22;283(34):23129-38. doi: 10.1074/jbc.M800478200. Epub 2008 Jun 12.

PMID:
18550542
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Cyclic AMP/PKA-Promoted Apoptosis: Insights from Studies of S49 Lymphoma Cells.

Insel PA, Wilderman A, Zhang L, Keshwani MM, Zambon AC.

Horm Metab Res. 2014 Jul 16. [Epub ahead of print]

PMID:
25028794
[PubMed - as supplied by publisher]

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