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Items: 1 to 20 of 164


The Werner's Syndrome RecQ helicase/exonuclease at the nexus of cancer and aging.

Chun SG, Shaeffer DS, Bryant-Greenwood PK.

Hawaii Med J. 2011 Mar;70(3):52-5. Review.


Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.

Futami K, Ishikawa Y, Goto M, Furuichi Y, Sugimoto M.

Cancer Sci. 2008 May;99(5):843-8. doi: 10.1111/j.1349-7006.2008.00778.x. Epub 2008 Feb 26. Review.


WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.

Chen L, Huang S, Lee L, Davalos A, Schiestl RH, Campisi J, Oshima J.

Aging Cell. 2003 Aug;2(4):191-9.


A novel mutation of the WRN gene in a Chinese patient with Werner syndrome.

Zhao N, Hao F, Qu T, Zuo YG, Wang BX.

Clin Exp Dermatol. 2008 May;33(3):278-81. doi: 10.1111/j.1365-2230.2007.02641.x. Epub 2008 Jan 16.


The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis.

Muftuoglu M, Oshima J, von Kobbe C, Cheng WH, Leistritz DF, Bohr VA.

Hum Genet. 2008 Nov;124(4):369-77. doi: 10.1007/s00439-008-0562-0. Epub 2008 Sep 23. Review.


Physical and functional interaction between p53 and the Werner's syndrome protein.

Blander G, Kipnis J, Leal JF, Yu CE, Schellenberg GD, Oren M.

J Biol Chem. 1999 Oct 8;274(41):29463-9.


The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation.

Opresko PL, Sowd G, Wang H.

PLoS One. 2009;4(3):e4825. doi: 10.1371/journal.pone.0004825. Epub 2009 Mar 13.


The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro.

Mason PA, Boubriak I, Robbins T, Lasala R, Saunders R, Cox LS.

Age (Dordr). 2013 Jun;35(3):793-806. doi: 10.1007/s11357-012-9411-0. Epub 2012 May 5.


Werner syndrome and mutations of the WRN and LMNA genes in France.

Uhrhammer NA, Lafarge L, Dos Santos L, Domaszewska A, Lange M, Yang Y, Aractingi S, Bessis D, Bignon YJ.

Hum Mutat. 2006 Jul;27(7):718-9.


Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.

Agrelo R, Cheng WH, Setien F, Ropero S, Espada J, Fraga MF, Herranz M, Paz MF, Sanchez-Cespedes M, Artiga MJ, Guerrero D, Castells A, von Kobbe C, Bohr VA, Esteller M.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8822-7. Epub 2006 May 24.


Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM.

Frank B, Hoffmeister M, Klopp N, Illig T, Chang-Claude J, Brenner H.

Carcinogenesis. 2010 Mar;31(3):442-5. doi: 10.1093/carcin/bgp293. Epub 2009 Nov 27.


Asymmetry of DNA replication fork progression in Werner's syndrome.

Rodríguez-López AM, Jackson DA, Iborra F, Cox LS.

Aging Cell. 2002 Oct;1(1):30-9.


Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.

Yu CE, Oshima J, Wijsman EM, Nakura J, Miki T, Piussan C, Matthews S, Fu YH, Mulligan J, Martin GM, Schellenberg GD.

Am J Hum Genet. 1997 Feb;60(2):330-41.


Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA.

Rodríguez-López AM, Jackson DA, Nehlin JO, Iborra F, Warren AV, Cox LS.

Mech Ageing Dev. 2003 Feb;124(2):167-74.


Positional cloning of the Werner's syndrome gene.

Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, Martin GM, Mulligan J, Schellenberg GD.

Science. 1996 Apr 12;272(5259):258-62.


Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

Shen JC, Gray MD, Oshima J, Kamath-Loeb AS, Fry M, Loeb LA.

J Biol Chem. 1998 Dec 18;273(51):34139-44.


A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.

Wang Z, Xu Y, Tang J, Ma H, Qin J, Lu C, Wang X, Hu Z, Wang X, Shen H.

Breast Cancer Res Treat. 2009 Nov;118(1):169-75. doi: 10.1007/s10549-009-0327-z. Epub 2009 Feb 10.


WRN polymorphisms affect expression levels of plasminogen activator inhibitor type 1 in cultured fibroblasts.

Castro E, Oviedo-Rodríguez V, Angel-Chávez LI.

BMC Cardiovasc Disord. 2008 Feb 29;8:5. doi: 10.1186/1471-2261-8-5.

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