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Results: 1 to 20 of 95

1.

Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells.

Siegelin MD, Dohi T, Raskett CM, Orlowski GM, Powers CM, Gilbert CA, Ross AH, Plescia J, Altieri DC.

J Clin Invest. 2011 Apr;121(4):1349-60. doi: 10.1172/JCI44855.

PMID:
21364280
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s.

Chae YC, Caino MC, Lisanti S, Ghosh JC, Dohi T, Danial NN, Villanueva J, Ferrero S, Vaira V, Santambrogio L, Bosari S, Languino LR, Herlyn M, Altieri DC.

Cancer Cell. 2012 Sep 11;22(3):331-44. doi: 10.1016/j.ccr.2012.07.015.

PMID:
22975376
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response.

Manni S, Brancalion A, Tubi LQ, Colpo A, Pavan L, Cabrelle A, Ave E, Zaffino F, Di Maira G, Ruzzene M, Adami F, Zambello R, Pitari MR, Tassone P, Pinna LA, Gurrieri C, Semenzato G, Piazza F.

Clin Cancer Res. 2012 Apr 1;18(7):1888-900. doi: 10.1158/1078-0432.CCR-11-1789. Epub 2012 Feb 20.

PMID:
22351691
[PubMed - indexed for MEDLINE]
Free Article
4.

Landscape of the mitochondrial Hsp90 metabolome in tumours.

Chae YC, Angelin A, Lisanti S, Kossenkov AV, Speicher KD, Wang H, Powers JF, Tischler AS, Pacak K, Fliedner S, Michalek RD, Karoly ED, Wallace DC, Languino LR, Speicher DW, Altieri DC.

Nat Commun. 2013;4:2139. doi: 10.1038/ncomms3139.

PMID:
23842546
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells.

Caino MC, Chae YC, Vaira V, Ferrero S, Nosotti M, Martin NM, Weeraratna A, O'Connell M, Jernigan D, Fatatis A, Languino LR, Bosari S, Altieri DC.

J Clin Invest. 2013 Jul 1;123(7):2907-20. doi: 10.1172/JCI67841. Epub 2013 Jun 10.

PMID:
23921130
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network.

Kang BH, Plescia J, Dohi T, Rosa J, Doxsey SJ, Altieri DC.

Cell. 2007 Oct 19;131(2):257-70.

PMID:
17956728
[PubMed - indexed for MEDLINE]
Free Article
7.

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

Pyrko P, Schönthal AH, Hofman FM, Chen TC, Lee AS.

Cancer Res. 2007 Oct 15;67(20):9809-16.

PMID:
17942911
[PubMed - indexed for MEDLINE]
Free Article
8.

Down-regulation of RIP expression by 17-dimethylaminoethylamino-17-demethoxygeldanamycin promotes TRAIL-induced apoptosis in breast tumor cells.

Palacios C, López-Pérez AI, López-Rivas A.

Cancer Lett. 2010 Jan 28;287(2):207-15. doi: 10.1016/j.canlet.2009.06.012. Epub 2009 Jul 25.

PMID:
19632771
[PubMed - indexed for MEDLINE]
9.

The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma.

Atkinson GP, Nozell SE, Harrison DK, Stonecypher MS, Chen D, Benveniste EN.

Oncogene. 2009 Oct 22;28(42):3735-45. doi: 10.1038/onc.2009.232. Epub 2009 Aug 10.

PMID:
19668231
[PubMed - indexed for MEDLINE]
10.

Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition.

Dixit D, Sharma V, Ghosh S, Mehta VS, Sen E.

Cell Death Dis. 2012 Feb 9;3:e271. doi: 10.1038/cddis.2012.10.

PMID:
22318540
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Mitochondrial HSP90s and tumor cell metabolism.

Altieri DC.

Autophagy. 2013 Feb 1;9(2):244-5. doi: 10.4161/auto.22527. Epub 2012 Oct 29.

PMID:
23108292
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathway.

Badr CE, Wurdinger T, Nilsson J, Niers JM, Whalen M, Degterev A, Tannous BA.

Neuro Oncol. 2011 Nov;13(11):1213-24. doi: 10.1093/neuonc/nor067. Epub 2011 Jul 13.

PMID:
21757445
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Obligatory role of heat shock protein 90 in iNOS induction.

Luo S, Wang T, Qin H, Lei H, Xia Y.

Am J Physiol Cell Physiol. 2011 Jul;301(1):C227-33. doi: 10.1152/ajpcell.00493.2010. Epub 2011 Mar 23.

PMID:
21430289
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis.

Altieri DC.

Cell Mol Life Sci. 2013 Jul;70(14):2463-72. doi: 10.1007/s00018-012-1177-0. Epub 2012 Sep 30.

PMID:
23052217
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

17-AAG sensitized malignant glioma cells to death-receptor mediated apoptosis.

Siegelin MD, Habel A, Gaiser T.

Neurobiol Dis. 2009 Feb;33(2):243-9. doi: 10.1016/j.nbd.2008.10.005. Epub 2008 Nov 10.

PMID:
19027068
[PubMed - indexed for MEDLINE]
16.

Agents with selective estrogen receptor (ER) modulator activity induce apoptosis in vitro and in vivo in ER-negative glioma cells.

Hui AM, Zhang W, Chen W, Xi D, Purow B, Friedman GC, Fine HA.

Cancer Res. 2004 Dec 15;64(24):9115-23.

PMID:
15604281
[PubMed - indexed for MEDLINE]
Free Article
17.

Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells.

Ghosh JC, Siegelin MD, Dohi T, Altieri DC.

Cancer Res. 2010 Nov 15;70(22):8988-93. doi: 10.1158/0008-5472.CAN-10-2225. Epub 2010 Oct 26.

PMID:
20978188
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Global targeting of subcellular heat shock protein-90 networks for therapy of glioblastoma.

Siegelin MD, Plescia J, Raskett CM, Gilbert CA, Ross AH, Altieri DC.

Mol Cancer Ther. 2010 Jun;9(6):1638-46. doi: 10.1158/1535-7163.MCT-10-0097. Epub 2010 May 25.

PMID:
20501802
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90.

Kang BH, Plescia J, Song HY, Meli M, Colombo G, Beebe K, Scroggins B, Neckers L, Altieri DC.

J Clin Invest. 2009 Mar;119(3):454-64. doi: 10.1172/JCI37613. Epub 2009 Feb 23.

PMID:
19229106
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Cisplatin enhances the antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand gene therapy via recruitment of the mitochondria-dependent death signaling pathway.

Shamimi-Noori S, Yeow WS, Ziauddin MF, Xin H, Tran TL, Xie J, Loehfelm A, Patel P, Yang J, Schrump DS, Fang BL, Nguyen DM.

Cancer Gene Ther. 2008 Jun;15(6):356-70. doi: 10.1038/sj.cgt.7701120. Epub 2008 Feb 29.

PMID:
18309355
[PubMed - indexed for MEDLINE]

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