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Items: 1 to 20 of 961

1.

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

Linker RA, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P, Zeng W, Hronowsky X, Buko A, Chollate S, Ellrichmann G, Brück W, Dawson K, Goelz S, Wiese S, Scannevin RH, Lukashev M, Gold R.

Brain. 2011 Mar;134(Pt 3):678-92. doi: 10.1093/brain/awq386.

2.

Mechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases: therapeutic modulation via fumaric acid esters.

Lee DH, Gold R, Linker RA.

Int J Mol Sci. 2012;13(9):11783-803. doi: 10.3390/ijms130911783. Epub 2012 Sep 18.

3.

Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway.

Scannevin RH, Chollate S, Jung MY, Shackett M, Patel H, Bista P, Zeng W, Ryan S, Yamamoto M, Lukashev M, Rhodes KJ.

J Pharmacol Exp Ther. 2012 Apr;341(1):274-84. doi: 10.1124/jpet.111.190132. Epub 2012 Jan 20.

4.

Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation.

Petratos S, Ozturk E, Azari MF, Kenny R, Lee JY, Magee KA, Harvey AR, McDonald C, Taghian K, Moussa L, Mun Aui P, Siatskas C, Litwak S, Fehlings MG, Strittmatter SM, Bernard CC.

Brain. 2012 Jun;135(Pt 6):1794-818. doi: 10.1093/brain/aws100. Epub 2012 Apr 28.

5.

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB.

Taoufik E, Tseveleki V, Chu SY, Tselios T, Karin M, Lassmann H, Szymkowski DE, Probert L.

Brain. 2011 Sep;134(Pt 9):2722-35. doi: 10.1093/brain/awr203.

6.

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro.

Lewerenz J, Albrecht P, Tien ML, Henke N, Karumbayaram S, Kornblum HI, Wiedau-Pazos M, Schubert D, Maher P, Methner A.

J Neurochem. 2009 Oct;111(2):332-43. doi: 10.1111/j.1471-4159.2009.06347.x. Epub 2009 Aug 18.

7.

Neuroprotective dimethyl fumarate synergizes with immunomodulatory interferon beta to provide enhanced axon protection in autoimmune neuroinflammation.

Reick C, Ellrichmann G, Thöne J, Scannevin RH, Saft C, Linker RA, Gold R.

Exp Neurol. 2014 Jul;257:50-6. doi: 10.1016/j.expneurol.2014.04.003. Epub 2014 Apr 13.

PMID:
24731948
8.

Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis.

Linker RA, Lee DH, Demir S, Wiese S, Kruse N, Siglienti I, Gerhardt E, Neumann H, Sendtner M, Lühder F, Gold R.

Brain. 2010 Aug;133(Pt 8):2248-63. doi: 10.1093/brain/awq179.

9.

The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis.

Johnson DA, Amirahmadi S, Ward C, Fabry Z, Johnson JA.

Toxicol Sci. 2010 Apr;114(2):237-46. doi: 10.1093/toxsci/kfp274. Epub 2009 Nov 12.

10.

Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model.

Vergo S, Craner MJ, Etzensperger R, Attfield K, Friese MA, Newcombe J, Esiri M, Fugger L.

Brain. 2011 Feb;134(Pt 2):571-84. doi: 10.1093/brain/awq337. Epub 2011 Jan 13.

12.

Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis.

Pifarre P, Prado J, Baltrons MA, Giralt M, Gabarro P, Feinstein DL, Hidalgo J, Garcia A.

Acta Neuropathol. 2011 Apr;121(4):499-508. doi: 10.1007/s00401-010-0795-6. Epub 2011 Jan 15.

PMID:
21234581
13.

Locus coeruleus damage and noradrenaline reductions in multiple sclerosis and experimental autoimmune encephalomyelitis.

Polak PE, Kalinin S, Feinstein DL.

Brain. 2011 Mar;134(Pt 3):665-77. doi: 10.1093/brain/awq362. Epub 2011 Feb 4.

14.
16.

Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination.

Brambilla R, Ashbaugh JJ, Magliozzi R, Dellarole A, Karmally S, Szymkowski DE, Bethea JR.

Brain. 2011 Sep;134(Pt 9):2736-54. doi: 10.1093/brain/awr199.

17.

Inflammation modulates anxiety in an animal model of multiple sclerosis.

Peruga I, Hartwig S, Thöne J, Hovemann B, Gold R, Juckel G, Linker RA.

Behav Brain Res. 2011 Jun 20;220(1):20-9. doi: 10.1016/j.bbr.2011.01.018. Epub 2011 Jan 19.

PMID:
21255614
18.

Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival.

Vargas MR, Pehar M, Cassina P, Martínez-Palma L, Thompson JA, Beckman JS, Barbeito L.

J Biol Chem. 2005 Jul 8;280(27):25571-9. Epub 2005 May 3.

19.

Increased nuclear factor-erythroid 2 p45-related factor 2 activity protects SH-SY5Y cells against oxidative damage.

Cao TT, Ma L, Kandpal G, Warren L, Hess JF, Seabrook GR.

J Neurochem. 2005 Oct;95(2):406-17. Epub 2005 Aug 10.

20.

Effects of fumaric acid esters on blood-brain barrier tight junction proteins.

Bénardais K, Pul R, Singh V, Skripuletz T, Lee DH, Linker RA, Gudi V, Stangel M.

Neurosci Lett. 2013 Oct 25;555:165-70. doi: 10.1016/j.neulet.2013.09.038. Epub 2013 Sep 26.

PMID:
24076006
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