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Results: 1 to 20 of 97

1.

1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.

Trunz BB, Jędrysiak R, Tweats D, Brun R, Kaiser M, Suwiński J, Torreele E.

Eur J Med Chem. 2011 May;46(5):1524-35. doi: 10.1016/j.ejmech.2011.01.071. Epub 2011 Feb 26.

PMID:
21353728
[PubMed - indexed for MEDLINE]
2.

Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness).

Tweats D, Bourdin Trunz B, Torreele E.

Mutagenesis. 2012 Sep;27(5):523-32. doi: 10.1093/mutage/ges015. Epub 2012 Apr 26.

PMID:
22539226
[PubMed - indexed for MEDLINE]
Free Article
3.

Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.

Torreele E, Bourdin Trunz B, Tweats D, Kaiser M, Brun R, Mazué G, Bray MA, Pécoul B.

PLoS Negl Trop Dis. 2010 Dec 21;4(12):e923. doi: 10.1371/journal.pntd.0000923.

PMID:
21200426
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Antiparasitic nitroimidazoles. 1. Some 2-styryl-5-nitroimidazoles.

Ross WJ, Jamieson WB, McCowen MC.

J Med Chem. 1972 Oct;15(10):1035-40. No abstract available.

PMID:
4341747
[PubMed - indexed for MEDLINE]
5.

Chemotherapy of CNS-trypanosomiasis: the combined use of the arsenicals and nitro-compounds.

Jennings FW.

Trop Med Parasitol. 1991 Jun;42(2):139-42.

PMID:
1896771
[PubMed - indexed for MEDLINE]
6.

Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis.

Jacobs RT, Plattner JJ, Nare B, Wring SA, Chen D, Freund Y, Gaukel EG, Orr MD, Perales JB, Jenks M, Noe RA, Sligar JM, Zhang YK, Bacchi CJ, Yarlett N, Don R.

Future Med Chem. 2011 Aug;3(10):1259-78. doi: 10.4155/fmc.11.80.

PMID:
21859301
[PubMed - indexed for MEDLINE]
7.

Compounds containing 2-substituted imidazole ring for treatment against human African trypanosomiasis.

Samant BS, Sukhthankar MG.

Bioorg Med Chem Lett. 2011 Feb 1;21(3):1015-8. doi: 10.1016/j.bmcl.2010.12.040. Epub 2010 Dec 10.

PMID:
21211967
[PubMed - indexed for MEDLINE]
8.

Development of novel drugs for human African trypanosomiasis.

Brun R, Don R, Jacobs RT, Wang MZ, Barrett MP.

Future Microbiol. 2011 Jun;6(6):677-91. doi: 10.2217/fmb.11.44. Review.

PMID:
21707314
[PubMed - indexed for MEDLINE]
Free Article
9.

High functionalization of 5-nitro-1H-imidazole derivatives: the TDAE approach.

Juspin T, Zink L, Crozet MD, Terme T, Vanelle P.

Molecules. 2011 Aug 12;16(8):6883-993. doi: 10.3390/molecules16086883.

PMID:
21841727
[PubMed - indexed for MEDLINE]
Free Article
10.

Synthesis and biological activity of two metabolites of 1-methyl-5-(1-methylethyl)-2-nitro-1 H-imidazole, an antiprotozoal agent.

Cavalleri B, Volpe G, Arioli V, Lancini G.

J Med Chem. 1977 Nov;20(11):1522-5.

PMID:
199729
[PubMed - indexed for MEDLINE]
11.

Antiparasitic nitroimidazoles. 8. Derivatives of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole.

Ross WJ, Jamieson WB.

J Med Chem. 1975 Feb;18(2):158-61.

PMID:
804551
[PubMed - indexed for MEDLINE]
12.

Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement.

Jennings FW, Urquhart GM, Murray PK, Miller BM.

Trans R Soc Trop Med Hyg. 1983;77(5):693-8.

PMID:
6659049
[PubMed - indexed for MEDLINE]
13.

Snythesis and antiprotozoal activity of nitro derivatives of 2, 2'-biimidazole.

Melloni P, Metelli R, Bassini DF, Confalonieri C, Logemann W, de Carneri I, Trane F.

Arzneimittelforschung. 1975 Jan;25(1):9-14.

PMID:
167793
[PubMed - indexed for MEDLINE]
14.
15.

A new class of analogues of the bifunctional radiosensitizer alpha-(1-aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069): the cycloalkylaziridines.

Suto MJ, Stier MA, Werbel LM, Arundel-Suto CM, Leopold WR, Elliott WE, Sebolt-Leopold JS.

J Med Chem. 1991 Aug;34(8):2484-8.

PMID:
1875345
[PubMed - indexed for MEDLINE]
16.

Antiparasitic nitroimidazoles. 3. Synthesis of 2-(4-carboxystyryl)-5-nitro-1-vinylimidazole and related compounds.

Ross WJ, Jamieson WB, McCowen MC.

J Med Chem. 1973 Apr;16(4):347-52. No abstract available.

PMID:
4351912
[PubMed - indexed for MEDLINE]
17.

Anti-trypanosomal activities of DNA topoisomerase inhibitors.

Deterding A, Dungey FA, Thompson KA, Steverding D.

Acta Trop. 2005 Mar;93(3):311-6.

PMID:
15715983
[PubMed - indexed for MEDLINE]
18.

Effects of the nitro-group on the mutagenicity and toxicity of some benzamines.

Chung KT, Murdock CA, Zhou Y, Stevens SE Jr, Li YS, Wei CI, Fernando SY, Chou MW.

Environ Mol Mutagen. 1996;27(1):67-74.

PMID:
8625950
[PubMed - indexed for MEDLINE]
19.

Synthesis and in-vitro antibacterial activity of 5-substituted 1-methyl-4-nitro-1H-imidazoles.

Letafat B, Emami S, Aliabadi A, Mohammadhosseini N, Moshafi MH, Asadipour A, Shafiee A, Foroumadi A.

Arch Pharm (Weinheim). 2008 Aug;341(8):497-501. doi: 10.1002/ardp.200800022.

PMID:
18618489
[PubMed - indexed for MEDLINE]
20.

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.

Jones DC, Hallyburton I, Stojanovski L, Read KD, Frearson JA, Fairlamb AH.

Biochem Pharmacol. 2010 Nov 15;80(10):1478-86. doi: 10.1016/j.bcp.2010.07.038. Epub 2010 Aug 7.

PMID:
20696141
[PubMed - indexed for MEDLINE]
Free PMC Article

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