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Items: 1 to 20 of 143


Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.

Goldring MB, Otero M, Plumb DA, Dragomir C, Favero M, El Hachem K, Hashimoto K, Roach HI, Olivotto E, Borzì RM, Marcu KB.

Eur Cell Mater. 2011 Feb 24;21:202-20.


Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis.

Goldring MB.

Ther Adv Musculoskelet Dis. 2012 Aug;4(4):269-85. doi: 10.1177/1759720X12448454.


A 3D cartilage - inflammatory cell culture system for the modeling of human osteoarthritis.

Sun L, Wang X, Kaplan DL.

Biomaterials. 2011 Aug;32(24):5581-9. doi: 10.1016/j.biomaterials.2011.04.028. Epub 2011 May 12.


Treatment with SiMiaoFang, an anti-arthritis chinese herbal formula, inhibits cartilage matrix degradation in osteoarthritis rat model.

Xu Y, Liu Q, Liu ZL, Lim L, Chen WH, Lin N.

Rejuvenation Res. 2013 Oct;16(5):364-76. doi: 10.1089/rej.2013.1439.


Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice.

Blaney Davidson EN, Remst DF, Vitters EL, van Beuningen HM, Blom AB, Goumans MJ, van den Berg WB, van der Kraan PM.

J Immunol. 2009 Jun 15;182(12):7937-45. doi: 10.4049/jimmunol.0803991. Erratum in: J Immunol. 2010 Aug 15;185(4):2629.


IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation.

Olivotto E, Otero M, Astolfi A, Platano D, Facchini A, Pagani S, Flamigni F, Facchini A, Goldring MB, Borzì RM, Marcu KB.

PLoS One. 2013 Sep 2;8(9):e73024. doi: 10.1371/journal.pone.0073024. eCollection 2013.


Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism.

Goldring MB, Otero M, Tsuchimochi K, Ijiri K, Li Y.

Ann Rheum Dis. 2008 Dec;67 Suppl 3:iii75-82. doi: 10.1136/ard.2008.098764. Review.


The role of cytokines in osteoarthritis pathophysiology.

Fernandes JC, Martel-Pelletier J, Pelletier JP.

Biorheology. 2002;39(1-2):237-46. Review.


Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.

Shen J, Li J, Wang B, Jin H, Wang M, Zhang Y, Yang Y, Im HJ, O'Keefe R, Chen D.

Arthritis Rheum. 2013 Dec;65(12):3107-19. doi: 10.1002/art.38122.


Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.

Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, Shah M, Thompson EW.

Arthritis Rheum. 2009 Dec;60(12):3723-33. doi: 10.1002/art.25002.


Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis.

Xu L, Peng H, Glasson S, Lee PL, Hu K, Ijiri K, Olsen BR, Goldring MB, Li Y.

Arthritis Rheum. 2007 Aug;56(8):2663-73.


Identification of soluble 14-3-3∊ as a novel subchondral bone mediator involved in cartilage degradation in osteoarthritis.

Priam S, Bougault C, Houard X, Gosset M, Salvat C, Berenbaum F, Jacques C.

Arthritis Rheum. 2013 Jul;65(7):1831-42. doi: 10.1002/art.37951.


Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes.

Rosa SC, Rufino AT, Judas FM, Tenreiro CM, Lopes MC, Mendes AF.

J Cell Biochem. 2011 Oct;112(10):2813-24. doi: 10.1002/jcb.23196.


Activation of matrix metalloproteinases 2, 9, and 13 by activated protein C in human osteoarthritic cartilage chondrocytes.

Jackson MT, Moradi B, Smith MM, Jackson CJ, Little CB.

Arthritis Rheumatol. 2014 Jun;66(6):1525-36. doi: 10.1002/art.38401.


Age-related alterations in TGF beta signaling as a causal factor of cartilage degeneration in osteoarthritis.

van der Kraan PM.

Biomed Mater Eng. 2014;24(1 Suppl):75-80. doi: 10.3233/BME-140976.


Regulation of chondrocyte gene expression.

Hering TM.

Front Biosci. 1999 Oct 15;4:D743-61.

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