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Items: 1 to 20 of 105

1.

Structural basis for the inhibition of human alkyladenine DNA glycosylase (AAG) by 3,N4-ethenocytosine-containing DNA.

Lingaraju GM, Davis CA, Setser JW, Samson LD, Drennan CL.

J Biol Chem. 2011 Apr 15;286(15):13205-13. doi: 10.1074/jbc.M110.192435. Epub 2011 Feb 24.

2.

Hijacking of the human alkyl-N-purine-DNA glycosylase by 3,N4-ethenocytosine, a lipid peroxidation-induced DNA adduct.

Gros L, Maksimenko AV, Privezentzev CV, Laval J, Saparbaev MK.

J Biol Chem. 2004 Apr 23;279(17):17723-30. Epub 2004 Feb 2.

3.

Direct repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase.

Fu D, Samson LD.

DNA Repair (Amst). 2012 Jan 2;11(1):46-52. doi: 10.1016/j.dnarep.2011.10.004. Epub 2011 Nov 11.

4.

Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG).

Lee CY, Delaney JC, Kartalou M, Lingaraju GM, Maor-Shoshani A, Essigmann JM, Samson LD.

Biochemistry. 2009 Mar 10;48(9):1850-61. doi: 10.1021/bi8018898.

5.

Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.

Prorok P, Saint-Pierre C, Gasparutto D, Fedorova OS, Ishchenko AA, Leh H, Buckle M, Tudek B, Saparbaev M.

PLoS One. 2012;7(12):e51776. doi: 10.1371/journal.pone.0051776. Epub 2012 Dec 14. Erratum in: PLoS One. 2013;8(7). doi:10.1371/annotation/861eeca8-8296-46b7-8bdf-947a0c8db4fa.

6.

A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch.

Hang B, Medina M, Fraenkel-Conrat H, Singer B.

Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13561-6.

9.

Decreased repair activities of 1,N(6)-ethenoadenine and 3,N(4)-ethenocytosine in lung adenocarcinoma patients.

Speina E, Zielińska M, Barbin A, Gackowski D, Kowalewski J, Graziewicz MA, Siedlecki JA, Oliński R, Tudek B.

Cancer Res. 2003 Aug 1;63(15):4351-7. Erratum in: Cancer Res. 2003 Sep 15;63(18):6103.

10.
11.

Kinetic mechanism for the flipping and excision of 1,N(6)-ethenoadenine by human alkyladenine DNA glycosylase.

Wolfe AE, O'Brien PJ.

Biochemistry. 2009 Dec 8;48(48):11357-69. doi: 10.1021/bi9015082.

12.

Searching for DNA lesions: structural evidence for lower- and higher-affinity DNA binding conformations of human alkyladenine DNA glycosylase.

Setser JW, Lingaraju GM, Davis CA, Samson LD, Drennan CL.

Biochemistry. 2012 Jan 10;51(1):382-90. doi: 10.1021/bi201484k. Epub 2011 Dec 20.

13.

AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo.

Delaney JC, Smeester L, Wong C, Frick LE, Taghizadeh K, Wishnok JS, Drennan CL, Samson LD, Essigmann JM.

Nat Struct Mol Biol. 2005 Oct;12(10):855-60. Epub 2005 Oct 2.

PMID:
16200073
14.

Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase.

Jones LE Jr, Ying L, Hofseth AB, Jelezcova E, Sobol RW, Ambs S, Harris CC, Espey MG, Hofseth LJ, Wyatt MD.

Carcinogenesis. 2009 Dec;30(12):2123-9. doi: 10.1093/carcin/bgp256. Epub .

15.

Substitution of active site tyrosines with tryptophan alters the free energy for nucleotide flipping by human alkyladenine DNA glycosylase.

Hendershot JM, Wolfe AE, O'Brien PJ.

Biochemistry. 2011 Mar 22;50(11):1864-74. doi: 10.1021/bi101856a. Epub 2011 Feb 3.

16.
17.

Modeling the chemical step utilized by human alkyladenine DNA glycosylase: a concerted mechanism AIDS in selectively excising damaged purines.

Rutledge LR, Wetmore SD.

J Am Chem Soc. 2011 Oct 12;133(40):16258-69. doi: 10.1021/ja207181c. Epub 2011 Sep 21.

PMID:
21877721
18.

Human alkyladenine DNA glycosylase employs a processive search for DNA damage.

Hedglin M, O'Brien PJ.

Biochemistry. 2008 Nov 4;47(44):11434-45. doi: 10.1021/bi801046y. Epub 2008 Oct 8.

19.

Oxanine DNA glycosylase activity from Mammalian alkyladenine glycosylase.

Hitchcock TM, Dong L, Connor EE, Meira LB, Samson LD, Wyatt MD, Cao W.

J Biol Chem. 2004 Sep 10;279(37):38177-83. Epub 2004 Jul 7.

20.

Efficient recognition of an unpaired lesion by a DNA repair glycosylase.

Lyons DM, O'Brien PJ.

J Am Chem Soc. 2009 Dec 16;131(49):17742-3. doi: 10.1021/ja908378y.

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