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Results: 1 to 20 of 105

1.

Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain.

Ascher DB, Cromer BA, Morton CJ, Volitakis I, Cherny RA, Albiston AL, Chai SY, Parker MW.

Biochemistry. 2011 Apr 5;50(13):2611-22. doi: 10.1021/bi101893w. Epub 2011 Mar 9.

PMID:
21348480
[PubMed - indexed for MEDLINE]
2.

Insulin-regulated aminopeptidase: analysis of peptide substrate and inhibitor binding to the catalytic domain.

Ye S, Chai SY, Lew RA, Albiston AL.

Biol Chem. 2007 Apr;388(4):399-403.

PMID:
17391061
[PubMed - indexed for MEDLINE]
3.

Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase.

Ye S, Chai SY, Lew RA, Ascher DB, Morton CJ, Parker MW, Albiston AL.

Biochem Cell Biol. 2008 Jun;86(3):251-61. doi: 10.1139/o08-037.

PMID:
18523486
[PubMed - indexed for MEDLINE]
4.

Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP).

Lew RA, Mustafa T, Ye S, McDowall SG, Chai SY, Albiston AL.

J Neurochem. 2003 Jul;86(2):344-50.

PMID:
12871575
[PubMed - indexed for MEDLINE]
5.

Involvement of insulin-regulated aminopeptidase in the effects of the renin-angiotensin fragment angiotensin IV: a review.

Stragier B, De Bundel D, Sarre S, Smolders I, Vauquelin G, Dupont A, Michotte Y, Vanderheyden P.

Heart Fail Rev. 2008 Sep;13(3):321-37. Epub 2007 Nov 8. Review.

PMID:
17990104
[PubMed - indexed for MEDLINE]
6.

Structure-activity study of LVV-hemorphin-7: angiotensin AT4 receptor ligand and inhibitor of insulin-regulated aminopeptidase.

Lee J, Mustafa T, McDowall SG, Mendelsohn FA, Brennan M, Lew RA, Albiston AL, Chai SY.

J Pharmacol Exp Ther. 2003 Apr;305(1):205-11.

PMID:
12649370
[PubMed - indexed for MEDLINE]
Free Article
7.

Angiotensin AT4 receptor ligand interaction with cystinyl aminopeptidase and aminopeptidase N: [125I]Angiotensin IV only binds to the cystinyl aminopeptidase apo-enzyme.

Demaegdt H, Lenaerts PJ, Swales J, De Backer JP, Laeremans H, Le MT, Kersemans K, Vogel LK, Michotte Y, Vanderheyden P, Vauquelin G.

Eur J Pharmacol. 2006 Sep 28;546(1-3):19-27. Epub 2006 Jul 21.

PMID:
16919623
[PubMed - indexed for MEDLINE]
8.

Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase.

Chai SY, Yeatman HR, Parker MW, Ascher DB, Thompson PE, Mulvey HT, Albiston AL.

BMC Neurosci. 2008 Dec 3;9 Suppl 2:S14. doi: 10.1186/1471-2202-9-S2-S14. Review.

PMID:
19090987
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP).

Andersson H, Demaegdt H, Vauquelin G, Lindeberg G, Karlén A, Hallberg M, Erdélyi M, Hallberg A.

J Med Chem. 2010 Nov 25;53(22):8059-71. doi: 10.1021/jm100793t. Epub 2010 Nov 3.

PMID:
21047126
[PubMed - indexed for MEDLINE]
10.

Cyclic insulin-regulated aminopeptidase (IRAP)/AT4 receptor ligands.

Axén A, Lindeberg G, Demaegdt H, Vauquelin G, Karlén A, Hallberg M.

J Pept Sci. 2006 Nov;12(11):705-13.

PMID:
16967438
[PubMed - indexed for MEDLINE]
11.

Angiotensin IV interacts with a juxtamembrane site on AT(4)/IRAP suggesting an allosteric mechanism of enzyme modulation.

Caron AZ, Arguin G, Guillemette G.

Regul Pept. 2003 May 15;113(1-3):9-15.

PMID:
12686456
[PubMed - indexed for MEDLINE]
12.

Selective labeling of IRAP by the tritiated AT(4) receptor ligand [3H]Angiotensin IV and its stable analog [3H]AL-11.

Demaegdt H, Lukaszuk A, De Buyser E, De Backer JP, Szemenyei E, Tóth G, Chakravarthy S, Panicker M, Michotte Y, Tourwé D, Vauquelin G.

Mol Cell Endocrinol. 2009 Nov 13;311(1-2):77-86. doi: 10.1016/j.mce.2009.07.020. Epub 2009 Jul 28.

PMID:
19643163
[PubMed - indexed for MEDLINE]
13.

Alzheimer's, angiotensin IV and an aminopeptidase.

Albiston AL, Fernando R, Ye S, Peck GR, Chai SY.

Biol Pharm Bull. 2004 Jun;27(6):765-7. Review.

PMID:
15187413
[PubMed - indexed for MEDLINE]
Free Article
14.

Endogenous cystinyl aminopeptidase in Chinese hamster ovary cells: characterization by [125I]Ang IV binding and catalytic activity.

Demaegdt H, Vanderheyden P, De Backer JP, Mosselmans S, Laeremans H, Le MT, Kersemans V, Michotte Y, Vauquelin G.

Biochem Pharmacol. 2004 Sep 1;68(5):885-92.

PMID:
15294451
[PubMed - indexed for MEDLINE]
15.

Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2.

Andersson H, Demaegdt H, Vauquelin G, Lindeberg G, Karlén A, Hallberg M.

Bioorg Med Chem. 2008 Jul 15;16(14):6924-35. doi: 10.1016/j.bmc.2008.05.046. Epub 2008 May 27.

PMID:
18556208
[PubMed - indexed for MEDLINE]
16.

Characterization of a recombinant soluble form of human placental leucine aminopeptidase/oxytocinase expressed in Chinese hamster ovary cells.

Matsumoto H, Rogi T, Yamashiro K, Kodama S, Tsuruoka N, Hattori A, Takio K, Mizutani S, Tsujimoto M.

Eur J Biochem. 2000 Jan;267(1):46-52.

PMID:
10601849
[PubMed - indexed for MEDLINE]
Free Article
17.

Gene knockout of insulin-regulated aminopeptidase: loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory.

Albiston AL, Fernando RN, Yeatman HR, Burns P, Ng L, Daswani D, Diwakarla S, Pham V, Chai SY.

Neurobiol Learn Mem. 2010 Jan;93(1):19-30. doi: 10.1016/j.nlm.2009.07.011. Epub 2009 Aug 4.

PMID:
19660563
[PubMed - indexed for MEDLINE]
18.

Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase.

Albiston AL, Pham V, Ye S, Ng L, Lew RA, Thompson PE, Holien JK, Morton CJ, Parker MW, Chai SY.

Mol Pharmacol. 2010 Oct;78(4):600-7. doi: 10.1124/mol.110.065458. Epub 2010 Jul 13.

PMID:
20628006
[PubMed - indexed for MEDLINE]
Free Article
19.

Mutational analysis of the active site of human insulin-regulated aminopeptidase.

Laustsen PG, Vang S, Kristensen T.

Eur J Biochem. 2001 Jan;268(1):98-104.

PMID:
11121108
[PubMed - indexed for MEDLINE]
Free Article
20.

Angiotensin IV displays only low affinity for native insulin-regulated aminopeptidase (IRAP).

Demaegdt H, De Backer JP, Lukaszuk A, Tóth G, Szemenyei E, Tourwé D, Vauquelin G.

Fundam Clin Pharmacol. 2012 Apr;26(2):194-7. doi: 10.1111/j.1472-8206.2011.00948.x. Epub 2011 Apr 11.

PMID:
21477268
[PubMed - indexed for MEDLINE]

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