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21347804,22975733,32342712,23637318,24261755,27236390,24252045,31801637,20974317,25553607,26629984,21229375,28516890,29251032,24684408,23925361,31154414,28622048,26056119,26511996,21794769,30299202,27174398,29575803,24960220,26385018,27550060,25169728,24634205,23729804,23819335,19802651,25102861,25231180,28516886,34269927,18821691,23457383,24942540,20617358,26242859,29247149,32251060,24252016,22488116,25491492,31028551,28007755,25834203,20480201,21204103,24187110,29334721,26480957,23099471,23436260,27778459,29146040,25186226,22972745,26991245,21702090,30299241,28849709,24729685,26941130,24525910,26449724,26254548,20024554,30405318,23380997,31196844,29495891,25417119,25630309,31087542,28800780,30793749,24441151,21949007,28298563,26708444,26026604,24593201,22133618,29853455,25922848,32404541,25832859,23395494,26700586,24262929,29093249,27115145,29745884,25604867,25529071,27018857,22444783,20039425,28160426,24515813,19609487,26034149,30148441,24286472,25599685,25099958,25903819,26316581,27181115,26934116,27414105,23983039,29143933,33464147,28841363,27405509,28013198,24429164,24056521,26729950,29041951,25853305,30206670,23470089,27958380,28980085,27384149,28545509,36539458,27322646,26473986,25045250,30357484,23354163,24099961,29244149,21293859,28245350,24878740,23090655,25128513,26801332,23305631,24261754,28676287,30427250,25880658,31540528,29882440,23456321,27050636,28947313,35114930,25246640,22467922,26938156,36990790,27086948,28880691,26344671,31088167,19019888,25300699,23746537,24515410,31025930,28396064,26872426,29543846,26374404,27339827,25748133,22183834,20402381,24662551,31154416,30587928,30421069,24368514,25241333,27041992,25685108,31580188,28477897,30029613,25585627,25773655,24942661,24252054,23670804,27421886,29157669,30695794,31903822,27633821,32232740,28579757,33216287,26438386,27909081,23961673,27846745,25917892,25641885,32999229,23703358,25888920,27541023,22114882,32371387,30779461,28293968,30649524,27369643,24978393,27440258,31240499,21931942,33024253,32811969,21735355,32148143,23893036,23259628,25260843,32040761,28558744,33274666,22075063,27696756,32662413,35659282,29325462,25794569,31261500,30488231,32461558,32478417,21116333,22526833,28734675,35986420,27069354,19590933,24786929,29629732,33528012,28229812,23433960,30318269,28880689,24854377,26496968,34241658,24609058,23869169,22887851,32057667,29043871,26787505,25265656,22438671,22857979,25697557,33638167,30915650,35502504,20495924,26073022,27155213,25332171,27846751,27798725,35782029,31431998,18817647,32056400,24752345,28316139,36121851,27311186,24252004,27686747,28597609,28733791,25648633,22451032,25282581,29694426,30968569,28406764,30958574,30173151,23172750,29067495,27430176,34975837,31941801,26224305,28494214,22870473,22669600,21418781,29581384,30523477,31369575,18653811,24249328,22350573,32010889,28277841,25403696,34112702,29334841,26644233,25120354,29744142,24773727,24336338,27658491,28107624,32144625,28027930,25279845,30647443,21430660,24187104,30132358,25282455,19437089,26642378,29141313,26201085,35211491,24058910,34544951,23994996,32743864,25999757,22150003,29303702,26120866,32161846,29502236,26853518,21962389,24048113,33993216,23179004,32103892,26089907,28476652,22992145,27713619,25274241,28089978,26743640,23856853,32185362,27747493,32452351,27900570,16468045,30183597,25005576,29303703,18473972,17978466,19436841,25791259,26962613,23829620,26023856,36622132,30655091,33782288,24307431,27085681,24630585,35110134,29925278,27670839,31969215,33576887,27747585,21968316,23306184,28374627,24730974,29427826,21419125,21107634,20221663,31907758,22433919,34538944,36977534,34750666,27050507,25529033,29946742,31159524,33630272,22830205,21441056,22398373,31049490,25267563,29622022,24517555,28578645,30632931,19652436,34874836,30112846,27182063,26806369,29529897,23782588,24591094,35663154,24854376,34882100,22117383,20065633,36377584,18407769,29955380,27432105,19701637,30707391,30859494,34791076,29924032,33180360,25160020,28689441,24760466,24309452,29362962,36106542,30809900,31891116,30148175,36062738,34385832,33589561,36145690,24863079,28936808,33934070,34393104,32896267,34011407,29077900,27747515,24821853,35188603,29995999,24533556,35261706,34001304,33758819,24739610,34552181,22491018,35818342,21963739,26934300,27458623,35628558,27747579,21234291,28290137,36381210,33255028,33108799,36526232,28572233,6678196,29849651,25648415,33080909,32685912,28781267,22870451,36688476,31431957,31911769,19707430,29578355,36131317,26819753,29256232,7455635,24038595,23315786,34820342,35886067,2441920,35713462,34778324,36533996,37039742,23325036,35350923,28757342,36143006,22046525,3000794,28017819,35655317,24524085,33788913,772817,28575416,20421913,1540033,2883443,34251326,30632015,28980909,26860742,23374105,7455636,16818462,33937333,23342244,6678200,28861599,31019572,7295485,35308307,33240406,35399969,23129740,36443570,4063622,27790001,19209259,36065465,33804790,30874871,22431927,32397399,6237660,35890412,8948290,24531503,30423923,33790504,35011830,34533616,24796134,2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Year	Number of Results
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The efficacy and safety of reinstitution of tocilizumab in patients with relapsed active rheumatoid arthritis after long-term withdrawal of tocilizumab: retreatment of patients with rheumatoid arthritis with novel anti-IL-6 receptor antibody after a long-term interval following SAMURAI: the RONIN study.

Sagawa A. Sagawa A. Mod Rheumatol. 2011 Aug;21(4):352-8. doi: 10.1007/s10165-011-0419-6. Epub 2011 Feb 24. Mod Rheumatol. 2011. PMID: 21347804

Therapeutic efficacy of tocilizumab in patients with rheumatoid arthritis refractory to anti-tumor-necrosis-factor inhibitors: 1 year follow-up with low-field extremity MRI.

Suzuki T, Horikoshi M, Sugihara M, Hirota T, Ogishima H, Umeda N, Kondo Y, Tsuboi H, Hayashi T, Chino Y, Matsumoto I, Sumida T. Suzuki T, et al. Mod Rheumatol. 2013 Jul;23(4):782-7. doi: 10.1007/s10165-012-0746-2. Epub 2012 Sep 14. Mod Rheumatol. 2013. PMID: 22975733

Tocilizumab, an anti-interleukin-6 receptor antibody, efficiently ameliorates persistent joint inflammation in rheumatoid arthritis.

Hirabayashi Y. Hirabayashi Y. Mod Rheumatol. 2021 Jan;31(1):70-79. doi: 10.1080/14397595.2020.1761078. Epub 2020 May 18. Mod Rheumatol. 2021. PMID: 32342712

Serum interleukin 6 before and after therapy with tocilizumab is a principal biomarker in patients with rheumatoid arthritis.

Shimamoto K, Ito T, Ozaki Y, Amuro H, Tanaka A, Nishizawa T, Son Y, Inaba M, Nomura S. Shimamoto K, et al. J Rheumatol. 2013 Jul;40(7):1074-81. doi: 10.3899/jrheum.121389. Epub 2013 May 1. J Rheumatol. 2013. PMID: 23637318

Retreatment efficacy and safety of tocilizumab in patients with rheumatoid arthritis in recurrence (RESTORE) study.

Nishimoto N, Amano K, Hirabayashi Y, Horiuchi T, Ishii T, Iwahashi M, Iwamoto M, Kohsaka H, Kondo M, Matsubara T, Mimura T, Miyahara H, Ohta S, Saeki Y, Saito K, Sano H, Takasugi K, Takeuchi T, Tohma S, Tsuru T, Ueki Y, Yamana J, Hashimoto J, Matsutani T, Murakami M, Takagi N. Nishimoto N, et al. Mod Rheumatol. 2014 Jan;24(1):26-32. doi: 10.3109/14397595.2013.854080. Mod Rheumatol. 2014. PMID: 24261755

Tocilizumab efficacy and safety in rheumatoid arthritis patients after inadequate response to disease-modifying anti-rheumatic drugs oranti-tumor necrosis factor.

Abdulkader OAF, Qushmaq K, Aljishi F. Abdulkader OAF, et al. Ann Saudi Med. 2016 May-Jun;36(3):190-6. doi: 10.5144/0256-4947.2016.190. Ann Saudi Med. 2016. PMID: 27236390 Free PMC article. Clinical Trial.

Effect of interleukin-6 receptor inhibitor, tocilizumab, in preventing joint destruction in patients with rheumatoid arthritis showing inadequate response to TNF inhibitors.

Tanaka Y, Takeuchi T, Amano K, Saito K, Hanami K, Nawata M, Fukuyo S, Kameda H, Kaneko Y, Kurasawa T, Nagasawa H, Hoshi D, Sato E, Yamanaka H. Tanaka Y, et al. Mod Rheumatol. 2014 May;24(3):399-404. doi: 10.3109/14397595.2013.843757. Epub 2013 Nov 5. Mod Rheumatol. 2014. PMID: 24252045

Levels of CXCL13 and sICAM-1 correlate with disease activity score in patients with rheumatoid arthritis treated with tocilizumab.

Tuckwell K, Gabay C, Sornasse T, Laubender RP, Wang J, Townsend MJ. Tuckwell K, et al. Adv Rheumatol. 2019 Dec 4;59(1):54. doi: 10.1186/s42358-019-0097-1. Adv Rheumatol. 2019. PMID: 31801637

Subset analysis of patients experiencing clinical events of a potentially immunogenic nature in the pivotal clinical trials of tocilizumab for rheumatoid arthritis: Evaluation of an antidrug antibody ELISA using clinical adverse event-driven immunogenicity testing.

Stubenrauch K, Wessels U, Birnboeck H, Ramirez F, Jahreis A, Schleypen J. Stubenrauch K, et al. Clin Ther. 2010 Aug;32(9):1597-609. doi: 10.1016/j.clinthera.2010.07.021. Clin Ther. 2010. PMID: 20974317

Safety of subcutaneous versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with rheumatoid arthritis.

McLaughlin M, Östör A. McLaughlin M, et al. Expert Opin Drug Saf. 2015 Mar;14(3):429-37. doi: 10.1517/14740338.2015.998198. Epub 2015 Jan 2. Expert Opin Drug Saf. 2015. PMID: 25553607 Review.

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