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Shortened {beta}-cell lifespan leads to {beta}-cell deficit in a rodent model of type 2 diabetes.

Manesso E, Toffolo GM, Butler AE, Butler PC, Cobelli C.

Am J Physiol Endocrinol Metab. 2011 May;300(5):E933-8. doi: 10.1152/ajpendo.00504.2010. Epub 2011 Feb 22.


Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP rat.

Manesso E, Toffolo GM, Saisho Y, Butler AE, Matveyenko AV, Cobelli C, Butler PC.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E323-30. doi: 10.1152/ajpendo.00284.2009. Epub 2009 May 26.


The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.

Cnop M, Hughes SJ, Igoillo-Esteve M, Hoppa MB, Sayyed F, van de Laar L, Gunter JH, de Koning EJ, Walls GV, Gray DW, Johnson PR, Hansen BC, Morris JF, Pipeleers-Marichal M, Cnop I, Clark A.

Diabetologia. 2010 Feb;53(2):321-30. doi: 10.1007/s00125-009-1562-x. Epub 2009 Oct 24.


Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1.

Maedler K, Schumann DM, Schulthess F, Oberholzer J, Bosco D, Berney T, Donath MY.

Diabetes. 2006 Sep;55(9):2455-62.


Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes.

Chen J, Hui ST, Couto FM, Mungrue IN, Davis DB, Attie AD, Lusis AJ, Davis RA, Shalev A.

FASEB J. 2008 Oct;22(10):3581-94. doi: 10.1096/fj.08-111690. Epub 2008 Jun 13.


Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.

Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC.

Diabetes. 2003 Jan;52(1):102-10.


Progressive histopathological changes and β-cell loss in the pancreas of a new spontaneous rat model of type 2 diabetes.

Riccillo FL, Bracamonte MI, Montenegro S, Martínez SM, Ronderos JR.

Tissue Cell. 2012 Apr;44(2):101-10. doi: 10.1016/j.tice.2011.12.002. Epub 2012 Jan 12.


Islet β cell mass in diabetes and how it relates to function, birth, and death.

Weir GC, Bonner-Weir S.

Ann N Y Acad Sci. 2013 Apr;1281:92-105. doi: 10.1111/nyas.12031. Epub 2013 Jan 30. Review.


β-Cell failure in type 2 diabetes: a case of asking too much of too few?

Costes S, Langen R, Gurlo T, Matveyenko AV, Butler PC.

Diabetes. 2013 Feb;62(2):327-35. doi: 10.2337/db12-1326.


Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats.

Dhar A, Dhar I, Jiang B, Desai KM, Wu L.

Diabetes. 2011 Mar;60(3):899-908. doi: 10.2337/db10-0627. Epub 2011 Feb 7.


Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress.

Matveyenko AV, Gurlo T, Daval M, Butler AE, Butler PC.

Diabetes. 2009 Apr;58(4):906-16. doi: 10.2337/db08-1464. Epub 2009 Jan 16.


Beta cell mass in diabetes: a realistic therapeutic target?

Meier JJ.

Diabetologia. 2008 May;51(5):703-13. doi: 10.1007/s00125-008-0936-9. Epub 2008 Mar 4. Review.


Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models.

Liadis N, Salmena L, Kwan E, Tajmir P, Schroer SA, Radziszewska A, Li X, Sheu L, Eweida M, Xu S, Gaisano HY, Hakem R, Woo M.

Diabetes. 2007 Sep;56(9):2302-11. Epub 2007 Jun 11.


Mechanisms of beta-cell death in type 2 diabetes.

Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, Eppler E, Reinecke M.

Diabetes. 2005 Dec;54 Suppl 2:S108-13. Review.


Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC.

Diabetologia. 2005 Nov;48(11):2221-8. Epub 2005 Oct 5.

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