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Results: 1 to 20 of 103

1.

Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K.

Kim JE, Lee DE, Lee KW, Son JE, Seo SK, Li J, Jung SK, Heo YS, Mottamal M, Bode AM, Dong Z, Lee HJ.

Cancer Prev Res (Phila). 2011 Apr;4(4):582-91. doi: 10.1158/1940-6207.CAPR-11-0032. Epub 2011 Feb 17.

PMID:
21330379
[PubMed - indexed for MEDLINE]
2.

Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling.

Kang NJ, Lee KW, Kwon JY, Hwang MK, Rogozin EA, Heo YS, Bode AM, Lee HJ, Dong Z.

Cancer Prev Res (Phila). 2008 Dec;1(7):522-31. doi: 10.1158/1940-6207.CAPR-08-0071.

PMID:
19139002
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer.

Jung SK, Kim JE, Lee SY, Lee MH, Byun S, Kim YA, Lim TG, Reddy K, Huang Z, Bode AM, Lee HJ, Lee KW, Dong Z.

Carcinogenesis. 2014 Jan;35(1):123-30. doi: 10.1093/carcin/bgt266. Epub 2013 Aug 2.

PMID:
23913940
[PubMed - indexed for MEDLINE]
4.

Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine.

Lee KW, Kang NJ, Heo YS, Rogozin EA, Pugliese A, Hwang MK, Bowden GT, Bode AM, Lee HJ, Dong Z.

Cancer Res. 2008 Feb 1;68(3):946-55. doi: 10.1158/0008-5472.CAN-07-3140.

PMID:
18245498
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1.

Lee KW, Kang NJ, Rogozin EA, Kim HG, Cho YY, Bode AM, Lee HJ, Surh YJ, Bowden GT, Dong Z.

Carcinogenesis. 2007 Sep;28(9):1918-27. Epub 2007 Aug 11.

PMID:
17693661
[PubMed - indexed for MEDLINE]
Free Article
6.

A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases.

Liu H, Liu K, Huang Z, Park CM, Thimmegowda NR, Jang JH, Ryoo IJ, He L, Kim SO, Oi N, Lee KW, Soung NK, Bode AM, Yang Y, Zhou X, Erikson RL, Ahn JS, Hwang J, Kim KE, Dong Z, Kim BY.

J Biol Chem. 2013 Sep 6;288(36):25924-37. doi: 10.1074/jbc.M113.464669. Epub 2013 Jul 25.

PMID:
23888052
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K.

Oi N, Chen H, Ok Kim M, Lubet RA, Bode AM, Dong Z.

Cancer Prev Res (Phila). 2012 Sep;5(9):1103-14. doi: 10.1158/1940-6207.CAPR-11-0397. Epub 2012 Jul 17.

PMID:
22805054
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway.

Kang NJ, Lee KW, Rogozin EA, Cho YY, Heo YS, Bode AM, Lee HJ, Dong Z.

J Biol Chem. 2007 Nov 9;282(45):32856-66. Epub 2007 Aug 27.

PMID:
17724030
[PubMed - indexed for MEDLINE]
Free Article
9.

CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo.

Kim DJ, Lee MH, Reddy K, Li Y, Lim do Y, Xie H, Lee SY, Yeom YI, Bode AM, Dong Z.

Carcinogenesis. 2013 May;34(5):1134-43. doi: 10.1093/carcin/bgt015. Epub 2013 Jan 25.

PMID:
23354306
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Antitumor effects of novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor, SMK-17.

Kiga M, Tanzawa F, Iwasaki S, Inaba F, Fujiwara K, Iwadare H, Echigo T, Nakamura Y, Shibata T, Suzuki K, Yasumatsu I, Nakayama A, Sasazawa Y, Tashiro E, Imoto M, Kurakata S.

Anticancer Drugs. 2012 Jan;23(1):119-30. doi: 10.1097/CAD.0b013e32834c6a33.

PMID:
22008853
[PubMed - indexed for MEDLINE]
11.

5-deoxykaempferol plays a potential therapeutic role by targeting multiple signaling pathways in skin cancer.

Lee KM, Lee KW, Byun S, Jung SK, Seo SK, Heo YS, Bode AM, Lee HJ, Dong Z.

Cancer Prev Res (Phila). 2010 Apr;3(4):454-65. doi: 10.1158/1940-6207.CAPR-09-0137. Epub 2010 Mar 16.

PMID:
20233901
[PubMed - indexed for MEDLINE]
12.

Identification of 4-anilino-3-quinolinecarbonitrile inhibitors of mitogen-activated protein/extracellular signal-regulated kinase 1 kinase.

Mallon R, Feldberg L, Kim S, Collins K, Wojciechowicz D, Kohler C, Kovacs D, Discafani C, Zhang N, Wu B, Floyd B, Powell D, Berger D.

Mol Cancer Ther. 2004 Jun;3(6):755-62.

PMID:
15210862
[PubMed - indexed for MEDLINE]
Free Article
13.

MEK1/2 inhibitor selumetinib (AZD6244) inhibits growth of ovarian clear cell carcinoma in a PEA-15-dependent manner in a mouse xenograft model.

Bartholomeusz C, Oishi T, Saso H, Akar U, Liu P, Kondo K, Kazansky A, Krishnamurthy S, Lee J, Esteva FJ, Kigawa J, Ueno NT.

Mol Cancer Ther. 2012 Feb;11(2):360-9. doi: 10.1158/1535-7163.MCT-11-0400. Epub 2011 Dec 5.

PMID:
22144664
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Activation of the MEK-S6 pathway in high-grade ovarian cancers.

Ventura AP, Radhakrishnan S, Green A, Rajaram SK, Allen AN, O'Briant K, Schummer M, Karlan B, Urban N, Tewari M, Drescher C, Knudsen BS.

Appl Immunohistochem Mol Morphol. 2010 Dec;18(6):499-508. doi: 10.1097/PAI.0b013e3181e53e1c.

PMID:
20661131
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.

Blalock WL, Navolanic PM, Steelman LS, Shelton JG, Moye PW, Lee JT, Franklin RA, Mirza A, McMahon M, White MK, McCubrey JA.

Leukemia. 2003 Jun;17(6):1058-67.

PMID:
12764369
[PubMed - indexed for MEDLINE]
16.

KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer.

Hong SW, Jung KH, Park BH, Zheng HM, Lee HS, Choi MJ, Yun JI, Kang NS, Lee J, Hong SS.

Cancer Lett. 2013 May 10;332(1):74-82. doi: 10.1016/j.canlet.2013.01.015. Epub 2013 Jan 21.

PMID:
23348694
[PubMed - indexed for MEDLINE]
17.

Direct targeting of MEK1/2 and RSK2 by silybin induces cell-cycle arrest and inhibits melanoma cell growth.

Lee MH, Huang Z, Kim DJ, Kim SH, Kim MO, Lee SY, Xie H, Park SJ, Kim JY, Kundu JK, Bode AM, Surh YJ, Dong Z.

Cancer Prev Res (Phila). 2013 May;6(5):455-65. doi: 10.1158/1940-6207.CAPR-12-0425. Epub 2013 Feb 27.

PMID:
23447564
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Luteolin inhibits protein kinase C(epsilon) and c-Src activities and UVB-induced skin cancer.

Byun S, Lee KW, Jung SK, Lee EJ, Hwang MK, Lim SH, Bode AM, Lee HJ, Dong Z.

Cancer Res. 2010 Mar 15;70(6):2415-23. doi: 10.1158/0008-5472.CAN-09-4093. Epub 2010 Mar 9.

PMID:
20215519
[PubMed - indexed for MEDLINE]
Free Article
19.

Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase.

Kang NJ, Lee KW, Lee DE, Rogozin EA, Bode AM, Lee HJ, Dong Z.

J Biol Chem. 2008 Jul 25;283(30):20664-73. doi: 10.1074/jbc.M800263200. Epub 2008 Jun 2.

PMID:
18519570
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Phosphoinositol 3-kinase, a novel target molecule for the inhibitory effects of juglone on TPA-induced cell transformation.

Chae JI, Cho JH, Kim DJ, Lee KA, Cho MK, Nam HS, Woo KM, Lee SH, Shim JH.

Int J Mol Med. 2012 Jul;30(1):8-14. doi: 10.3892/ijmm.2012.969. Epub 2012 Apr 10.

PMID:
22505246
[PubMed - indexed for MEDLINE]

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