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Results: 1 to 20 of 108

1.

CDK8: a positive regulator of transcription.

Galbraith MD, Donner AJ, Espinosa JM.

Transcription. 2010 Jul-Aug;1(1):4-12. doi: 10.4161/trns.1.1.12373. Review.

PMID:
21327159
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation.

Belakavadi M, Fondell JD.

Mol Cell Biol. 2010 May;30(10):2437-48. doi: 10.1128/MCB.01541-09. Epub 2010 Mar 15.

PMID:
20231357
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.

Tsutsui T, Fukasawa R, Shinmyouzu K, Nakagawa R, Tobe K, Tanaka A, Ohkuma Y.

J Biol Chem. 2013 Jul 19;288(29):20955-65. doi: 10.1074/jbc.M113.486746. Epub 2013 Jun 9.

PMID:
23749998
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation.

Furumoto T, Tanaka A, Ito M, Malik S, Hirose Y, Hanaoka F, Ohkuma Y.

Genes Cells. 2007 Jan;12(1):119-32.

PMID:
17212659
[PubMed - indexed for MEDLINE]
5.

The two faces of Cdk8, a positive/negative regulator of transcription.

Nemet J, Jelicic B, Rubelj I, Sopta M.

Biochimie. 2014 Feb;97:22-7. doi: 10.1016/j.biochi.2013.10.004. Epub 2013 Oct 15. Review.

PMID:
24139904
[PubMed - indexed for MEDLINE]
6.

CDK8 is a positive regulator of transcriptional elongation within the serum response network.

Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM.

Nat Struct Mol Biol. 2010 Feb;17(2):194-201. doi: 10.1038/nsmb.1752. Epub 2010 Jan 24.

PMID:
20098423
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

CDK8 is a stimulus-specific positive coregulator of p53 target genes.

Donner AJ, Szostek S, Hoover JM, Espinosa JM.

Mol Cell. 2007 Jul 6;27(1):121-33.

PMID:
17612495
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.

Galbraith MD, Allen MA, Bensard CL, Wang X, Schwinn MK, Qin B, Long HW, Daniels DL, Hahn WC, Dowell RD, Espinosa JM.

Cell. 2013 Jun 6;153(6):1327-39. doi: 10.1016/j.cell.2013.04.048.

PMID:
23746844
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Cdk11-cyclinL controls the assembly of the RNA polymerase II mediator complex.

Drogat J, Migeot V, Mommaerts E, Mullier C, Dieu M, van Bakel H, Hermand D.

Cell Rep. 2012 Nov 29;2(5):1068-76. doi: 10.1016/j.celrep.2012.09.027. Epub 2012 Nov 1.

PMID:
23122962
[PubMed - indexed for MEDLINE]
Free Article
10.

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

Davis MA, Larimore EA, Fissel BM, Swanger J, Taatjes DJ, Clurman BE.

Genes Dev. 2013 Jan 15;27(2):151-6. doi: 10.1101/gad.207720.112. Epub 2013 Jan 15.

PMID:
23322298
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The Mediator complex and transcription regulation.

Poss ZC, Ebmeier CC, Taatjes DJ.

Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3. Review.

PMID:
24088064
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

CDK8 regulates E2F1 transcriptional activity through S375 phosphorylation.

Zhao J, Ramos R, Demma M.

Oncogene. 2013 Jul 25;32(30):3520-30. doi: 10.1038/onc.2012.364. Epub 2012 Sep 3.

PMID:
22945643
[PubMed - indexed for MEDLINE]
13.

Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator.

Gonzalez D, Hamidi N, Del Sol R, Benschop JJ, Nancy T, Li C, Francis L, Tzouros M, Krijgsveld J, Holstege FC, Conlan RS.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2500-5. doi: 10.1073/pnas.1307525111. Epub 2014 Feb 3.

PMID:
24550274
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Identification of target genes for the CDK subunits of the Mediator complex.

Tsutsui T, Fukasawa R, Tanaka A, Hirose Y, Ohkuma Y.

Genes Cells. 2011 Nov 27. doi: 10.1111/j.1365-2443.2011.01565.x. [Epub ahead of print]

PMID:
22117896
[PubMed - as supplied by publisher]
15.

Dysregulation of CDK8 and Cyclin C in tumorigenesis.

Xu W, Ji JY.

J Genet Genomics. 2011 Oct 20;38(10):439-52. doi: 10.1016/j.jgg.2011.09.002. Epub 2011 Sep 16. Review.

PMID:
22035865
[PubMed - indexed for MEDLINE]
16.

GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8.

Hirst M, Kobor MS, Kuriakose N, Greenblatt J, Sadowski I.

Mol Cell. 1999 May;3(5):673-8.

PMID:
10360183
[PubMed - indexed for MEDLINE]
Free Article
17.

Distinct roles for Mediator Cdk8 module subunits in Drosophila development.

Loncle N, Boube M, Joulia L, Boschiero C, Werner M, Cribbs DL, Bourbon HM.

EMBO J. 2007 Feb 21;26(4):1045-54. Epub 2007 Feb 8.

PMID:
17290221
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.

Turunen M, Spaeth JM, Keskitalo S, Park MJ, Kivioja T, Clark AD, Mäkinen N, Gao F, Palin K, Nurkkala H, Vähärautio A, Aavikko M, Kämpjärvi K, Vahteristo P, Kim CA, Aaltonen LA, Varjosalo M, Taipale J, Boyer TG.

Cell Rep. 2014 May 8;7(3):654-60. doi: 10.1016/j.celrep.2014.03.047. Epub 2014 Apr 18.

PMID:
24746821
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Human mediator kinase subunit CDK11 plays a negative role in viral activator VP16-dependent transcriptional regulation.

Tsutsui T, Umemura H, Tanaka A, Mizuki F, Hirose Y, Ohkuma Y.

Genes Cells. 2008 Aug;13(8):817-26. doi: 10.1111/j.1365-2443.2008.01208.x. Epub 2008 Jun 21.

PMID:
18651850
[PubMed - indexed for MEDLINE]
20.

The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II.

Elmlund H, Baraznenok V, Lindahl M, Samuelsen CO, Koeck PJ, Holmberg S, Hebert H, Gustafsson CM.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15788-93. Epub 2006 Oct 16.

PMID:
17043218
[PubMed - indexed for MEDLINE]
Free PMC Article

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