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p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects.

Bartlett BJ, Isakson P, Lewerenz J, Sanchez H, Kotzebue RW, Cumming RC, Harris GL, Nezis IP, Schubert DR, Simonsen A, Finley KD.

Autophagy. 2011 Jun;7(6):572-83. Epub 2011 Jun 1.


Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain.

Nezis IP, Simonsen A, Sagona AP, Finley K, Gaumer S, Contamine D, Rusten TE, Stenmark H, Brech A.

J Cell Biol. 2008 Mar 24;180(6):1065-71. doi: 10.1083/jcb.200711108. Epub 2008 Mar 17.


Quantitative analysis of autophagic activity in Drosophila neural tissues by measuring the turnover rates of pathway substrates.

Cumming RC, Simonsen A, Finley KD.

Methods Enzymol. 2008;451:639-51. doi: 10.1016/S0076-6879(08)03235-7.


p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.

Clausen TH, Lamark T, Isakson P, Finley K, Larsen KB, Brech A, Øvervatn A, Stenmark H, Bjørkøy G, Simonsen A, Johansen T.

Autophagy. 2010 Apr;6(3):330-44. Epub 2010 Apr 11.


The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates.

Lindmo K, Brech A, Finley KD, Gaumer S, Contamine D, Rusten TE, Stenmark H.

Autophagy. 2008 May;4(4):500-6. Epub 2008 Mar 3.


p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.

Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T.

J Cell Biol. 2005 Nov 21;171(4):603-14. Epub 2005 Nov 14.


Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.

Matsumoto G, Wada K, Okuno M, Kurosawa M, Nukina N.

Mol Cell. 2011 Oct 21;44(2):279-89. doi: 10.1016/j.molcel.2011.07.039.


Monitoring autophagic flux using Ref(2)P, the Drosophila p62 ortholog.

DeVorkin L, Gorski SM.

Cold Spring Harb Protoc. 2014 Sep 2;2014(9):959-66. doi: 10.1101/pdb.prot080333.


Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells.

Tanabe F, Yone K, Kawabata N, Sakakima H, Matsuda F, Ishidou Y, Maeda S, Abematsu M, Komiya S, Setoguchi T.

Autophagy. 2011 Dec;7(12):1462-71.


Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila.

Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD.

Autophagy. 2008 Feb;4(2):176-84. Epub 2007 Nov 6.


Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants.

de Castro IP, Costa AC, Celardo I, Tufi R, Dinsdale D, Loh SH, Martins LM.

Cell Death Dis. 2013 Oct 24;4:e873. doi: 10.1038/cddis.2013.394.


Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.

Myeku N, Figueiredo-Pereira ME.

J Biol Chem. 2011 Jun 24;286(25):22426-40. doi: 10.1074/jbc.M110.149252. Epub 2011 May 2.


p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.

Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G, Johansen T.

J Biol Chem. 2007 Aug 17;282(33):24131-45. Epub 2007 Jun 19.


Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila.

Nagy P, Kárpáti M, Varga A, Pircs K, Venkei Z, Takáts S, Varga K, Erdi B, Hegedűs K, Juhász G.

Autophagy. 2014 Mar;10(3):453-67. doi: 10.4161/auto.27442. Epub 2014 Jan 6.


The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins.

Taillebourg E, Gregoire I, Viargues P, Jacomin AC, Thevenon D, Faure M, Fauvarque MO.

Autophagy. 2012 May 1;8(5):767-79. doi: 10.4161/auto.19381. Epub 2012 May 1.


p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.

Christian F, Anthony DF, Vadrevu S, Riddell T, Day JP, McLeod R, Adams DR, Baillie GS, Houslay MD.

Cell Signal. 2010 Oct;22(10):1576-96. doi: 10.1016/j.cellsig.2010.06.003. Epub 2010 Jun 19.


NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets.

Lamark T, Kirkin V, Dikic I, Johansen T.

Cell Cycle. 2009 Jul 1;8(13):1986-90. Epub 2009 Jul 30.


Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila.

Pircs K, Nagy P, Varga A, Venkei Z, Erdi B, Hegedus K, Juhasz G.

PLoS One. 2012;7(8):e44214. doi: 10.1371/journal.pone.0044214. Epub 2012 Aug 31.


NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets.

Kirkin V, Lamark T, Johansen T, Dikic I.

Autophagy. 2009 Jul;5(5):732-3. Epub 2009 Jul 30.


p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies.

Saitoh Y, Fujikake N, Okamoto Y, Popiel HA, Hatanaka Y, Ueyama M, Suzuki M, Gaumer S, Murata M, Wada K, Nagai Y.

J Biol Chem. 2015 Jan 16;290(3):1442-53. doi: 10.1074/jbc.M114.590281. Epub 2014 Dec 5.

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