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Results: 1 to 20 of 100

1.

Modeling reveals that dynamic regulation of c-FLIP levels determines cell-to-cell distribution of CD95-mediated apoptosis.

Toivonen HT, Meinander A, Asaoka T, Westerlund M, Pettersson F, Mikhailov A, Eriksson JE, Saxén H.

J Biol Chem. 2011 May 27;286(21):18375-82. doi: 10.1074/jbc.M110.177097. Epub 2011 Feb 15.

PMID:
21324892
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL.

Fricker N, Beaudouin J, Richter P, Eils R, Krammer PH, Lavrik IN.

J Cell Biol. 2010 Aug 9;190(3):377-89. doi: 10.1083/jcb.201002060.

PMID:
20696707
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Rapid up-regulation of c-FLIP expression by BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas-mediated apoptosis in murine B lymphocytes.

Moriyama H, Yonehara S.

Immunol Lett. 2007 Mar 15;109(1):36-46. Epub 2007 Jan 22.

PMID:
17275920
[PubMed - indexed for MEDLINE]
5.

Regulation of CD95/Fas signaling at the DISC.

Lavrik IN, Krammer PH.

Cell Death Differ. 2012 Jan;19(1):36-41. doi: 10.1038/cdd.2011.155. Epub 2011 Nov 11. Review.

PMID:
22075988
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation.

Kober AM, Legewie S, Pforr C, Fricker N, Eils R, Krammer PH, Lavrik IN.

Cell Death Dis. 2011 Oct 6;2:e212. doi: 10.1038/cddis.2011.93.

PMID:
21975294
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The role of c-FLIP in modulation of CD95-induced apoptosis.

Scaffidi C, Schmitz I, Krammer PH, Peter ME.

J Biol Chem. 1999 Jan 15;274(3):1541-8.

PMID:
9880531
[PubMed - indexed for MEDLINE]
Free Article
8.

c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis.

Mathas S, Lietz A, Anagnostopoulos I, Hummel F, Wiesner B, Janz M, Jundt F, Hirsch B, Jöhrens-Leder K, Vornlocher HP, Bommert K, Stein H, Dörken B.

J Exp Med. 2004 Apr 19;199(8):1041-52. Epub 2004 Apr 12.

PMID:
15078899
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Dynamics within the CD95 death-inducing signaling complex decide life and death of cells.

Neumann L, Pforr C, Beaudouin J, Pappa A, Fricker N, Krammer PH, Lavrik IN, Eils R.

Mol Syst Biol. 2010;6:352. doi: 10.1038/msb.2010.6. Epub 2010 Mar 9.

PMID:
20212524
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

CD95-mediated apoptosis is impaired at receptor level by cellular FLICE-inhibitory protein (long form) in wild-type p53 human ovarian carcinoma.

Mezzanzanica D, Balladore E, Turatti F, Luison E, Alberti P, Bagnoli M, Figini M, Mazzoni A, Raspagliesi F, Oggionni M, Pilotti S, Canevari S.

Clin Cancer Res. 2004 Aug 1;10(15):5202-14.

PMID:
15297424
[PubMed - indexed for MEDLINE]
Free Article
11.

Downregulation of c-FLIP sensitizes DU145 prostate cancer cells to Fas-mediated apoptosis.

Hyer ML, Sudarshan S, Kim Y, Reed JC, Dong JY, Schwartz DA, Norris JS.

Cancer Biol Ther. 2002 Jul-Aug;1(4):401-6.

PMID:
12432255
[PubMed - indexed for MEDLINE]
Free Article
12.

Downregulation of FLIP by cycloheximide sensitizes human fat cells to CD95-induced apoptosis.

Fischer-Posovszky P, Keuper M, Nagel S, Hesse D, Schürmann A, Debatin KM, Strauss G, Wabitsch M.

Exp Cell Res. 2011 Sep 10;317(15):2200-9. doi: 10.1016/j.yexcr.2011.06.016. Epub 2011 Jul 2.

PMID:
21756905
[PubMed - indexed for MEDLINE]
13.

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex.

Krueger A, Schmitz I, Baumann S, Krammer PH, Kirchhoff S.

J Biol Chem. 2001 Jun 8;276(23):20633-40. Epub 2001 Mar 5.

PMID:
11279218
[PubMed - indexed for MEDLINE]
Free Article
14.

Resistance of cutaneous anaplastic large-cell lymphoma cells to apoptosis by death ligands is enhanced by CD30-mediated overexpression of c-FLIP.

Braun FK, Hirsch B, Al-Yacoub N, Dürkop H, Assaf C, Kadin ME, Sterry W, Eberle J.

J Invest Dermatol. 2010 Mar;130(3):826-40. doi: 10.1038/jid.2009.299. Epub 2009 Nov 5.

PMID:
19890350
[PubMed - indexed for MEDLINE]
Free Article
15.

Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kappaB.

Okamoto K, Fujisawa J, Reth M, Yonehara S.

Genes Cells. 2006 Feb;11(2):177-91.

PMID:
16436054
[PubMed - indexed for MEDLINE]
16.

Inhibition of CD95 apoptotic signaling by interferon-gamma in human osteoarthritic chondrocytes is associated with increased expression of FLICE inhibitory protein.

Grassi F, Piacentini A, Cristino S, Toneguzzi S, Facchini A, Lisignoli G.

Arthritis Rheum. 2004 Feb;50(2):498-506.

PMID:
14872492
[PubMed - indexed for MEDLINE]
Free Article
18.

Triggering of death receptor apoptotic signaling by human papillomavirus 16 E2 protein in cervical cancer cell lines is mediated by interaction with c-FLIP.

Wang W, Fang Y, Sima N, Li Y, Li W, Li L, Han L, Liao S, Han Z, Gao Q, Li K, Deng D, Meng L, Zhou J, Wang S, Ma D.

Apoptosis. 2011 Jan;16(1):55-66. doi: 10.1007/s10495-010-0543-3.

PMID:
20882347
[PubMed - indexed for MEDLINE]
19.

Erythroid differentiation sensitizes K562 leukemia cells to TRAIL-induced apoptosis by downregulation of c-FLIP.

Hietakangas V, Poukkula M, Heiskanen KM, Karvinen JT, Sistonen L, Eriksson JE.

Mol Cell Biol. 2003 Feb;23(4):1278-91.

PMID:
12556488
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Calmodulin binding to cellular FLICE-like inhibitory protein modulates Fas-induced signalling.

Pawar PS, Micoli KJ, Ding H, Cook WJ, Kappes JC, Chen Y, McDonald JM.

Biochem J. 2008 Jun 15;412(3):459-68. doi: 10.1042/BJ20071507.

PMID:
18257744
[PubMed - indexed for MEDLINE]
Free Article

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