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Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum.

Gorgels TG, Waarsing JH, Herfs M, Versteeg D, Schoensiegel F, Sato T, Schlingemann RO, Ivandic B, Vermeer C, Schurgers LJ, Bergen AA.

J Mol Med (Berl). 2011 Nov;89(11):1125-35. doi: 10.1007/s00109-011-0782-y. Epub 2011 Jul 2.


Vitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticum.

Brampton C, Yamaguchi Y, Vanakker O, Van Laer L, Chen LH, Thakore M, De Paepe A, Pomozi V, Szabó PT, Martin L, Váradi A, Le Saux O.

Cell Cycle. 2011 Jun 1;10(11):1810-20. Epub 2011 Jun 1.


Atorvastatin counteracts aberrant soft tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6⁻/⁻).

Guo H, Li Q, Chou DW, Uitto J.

J Mol Med (Berl). 2013 Oct;91(10):1177-84. doi: 10.1007/s00109-013-1066-5. Epub 2013 Jun 27.


Pseudoxanthoma elasticum: molecular genetics and putative pathomechanisms.

Uitto J, Li Q, Jiang Q.

J Invest Dermatol. 2010 Mar;130(3):661-70. doi: 10.1038/jid.2009.411. Epub 2009 Dec 24.


Changes in dermal fibroblasts from Abcc6(-/-) mice are present before and after the onset of ectopic tissue mineralization.

Boraldi F, Bartolomeo A, Li Q, Uitto J, Quaglino D.

J Invest Dermatol. 2014 Jul;134(7):1855-61. doi: 10.1038/jid.2014.88. Epub 2014 Feb 13.


Pseudoxanthoma elasticum: reduced gamma-glutamyl carboxylation of matrix gla protein in a mouse model (Abcc6-/-).

Li Q, Jiang Q, Schurgers LJ, Uitto J.

Biochem Biophys Res Commun. 2007 Dec 14;364(2):208-13. Epub 2007 Oct 4.


Warfarin accelerates ectopic mineralization in Abcc6(-/-) mice: clinical relevance to pseudoxanthoma elasticum.

Li Q, Guo H, Chou DW, Harrington DJ, Schurgers LJ, Terry SF, Uitto J.

Am J Pathol. 2013 Apr;182(4):1139-50. doi: 10.1016/j.ajpath.2012.12.037. Epub 2013 Feb 15.


ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: relevance to pathomechanisms of pseudoxanthoma elasticum.

Fülöp K, Jiang Q, Wetering KV, Pomozi V, Szabó PT, Arányi T, Sarkadi B, Borst P, Uitto J, Váradi A.

Biochem Biophys Res Commun. 2011 Nov 25;415(3):468-71. doi: 10.1016/j.bbrc.2011.10.095. Epub 2011 Oct 28.


Pseudoxanthoma elasticum: oxidative stress and antioxidant diet in a mouse model (Abcc6-/-).

Li Q, Jiang Q, Uitto J.

J Invest Dermatol. 2008 May;128(5):1160-4. Epub 2007 Nov 29.


Targeted ablation of Abcc1 or Abcc3 in Abcc6(-/-) mice does not modify the ectopic mineralization process.

Li Q, Jiang Q, Larusso J, Klement JF, Sartorelli AC, Belinsky MG, Kruh GD, Uitto J.

Exp Dermatol. 2007 Oct;16(10):853-9.


Pseudoxanthoma elasticum: clinical phenotypes, molecular genetics and putative pathomechanisms.

Li Q, Jiang Q, Pfendner E, Váradi A, Uitto J.

Exp Dermatol. 2009 Jan;18(1):1-11. doi: 10.1111/j.1600-0625.2008.00795.x. Epub 2008 Oct 22. Review.


The mineralization phenotype in Abcc6 ( -/- ) mice is affected by Ggcx gene deficiency and genetic background--a model for pseudoxanthoma elasticum.

Li Q, Uitto J.

J Mol Med (Berl). 2010 Feb;88(2):173-81. doi: 10.1007/s00109-009-0522-8. Epub 2009 Sep 27.


Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum.

Gorgels TG, Hu X, Scheffer GL, van der Wal AC, Toonstra J, de Jong PT, van Kuppevelt TH, Levelt CN, de Wolf A, Loves WJ, Scheper RJ, Peek R, Bergen AA.

Hum Mol Genet. 2005 Jul 1;14(13):1763-73. Epub 2005 May 11.


Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues.

Klement JF, Matsuzaki Y, Jiang QJ, Terlizzi J, Choi HY, Fujimoto N, Li K, Pulkkinen L, Birk DE, Sundberg JP, Uitto J.

Mol Cell Biol. 2005 Sep;25(18):8299-310.


Parabiotic heterogenetic pairing of Abcc6-/-/Rag1-/- mice and their wild-type counterparts halts ectopic mineralization in a murine model of pseudoxanthoma elasticum.

Jiang Q, Oldenburg R, Otsuru S, Grand-Pierre AE, Horwitz EM, Uitto J.

Am J Pathol. 2010 Apr;176(4):1855-62. doi: 10.2353/ajpath.2010.090983. Epub 2010 Feb 25.


Vitamin K reduces hypermineralisation in zebrafish models of PXE and GACI.

Mackay EW, Apschner A, Schulte-Merker S.

Development. 2015 Mar 15;142(6):1095-101. doi: 10.1242/dev.113811.

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