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PPARδ activation acts cooperatively with 3-phosphoinositide-dependent protein kinase-1 to enhance mammary tumorigenesis.

Pollock CB, Yin Y, Yuan H, Zeng X, King S, Li X, Kopelovich L, Albanese C, Glazer RI.

PLoS One. 2011 Jan 13;6(1):e16215. doi: 10.1371/journal.pone.0016215.


Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis.

Yin Y, Russell RG, Dettin LE, Bai R, Wei ZL, Kozikowski AP, Kopelovich L, Glazer RI.

Cancer Res. 2005 May 1;65(9):3950-7. Erratum in: Cancer Res. 2005 Jul 1;65(13):5989. Cancer Res. 2005 Oct 1;65(19):9108. Kopleovich, Levy [corrected to Kopelovich, Levy].


PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation.

Yuan H, Lu J, Xiao J, Upadhyay G, Umans R, Kallakury B, Yin Y, Fant ME, Kopelovich L, Glazer RI.

Cancer Res. 2013 Jul 15;73(14):4349-61. doi: 10.1158/0008-5472.CAN-13-0322. Epub 2013 Jun 27.


The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.

Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR.

Curr Biol. 2000 Apr 20;10(8):439-48.


Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion.

Hutchinson JN, Jin J, Cardiff RD, Woodgett JR, Muller WJ.

Cancer Res. 2004 May 1;64(9):3171-8.


In vivo role of the phosphate groove of PDK1 defined by knockin mutation.

Collins BJ, Deak M, Murray-Tait V, Storey KG, Alessi DR.

J Cell Sci. 2005 Nov 1;118(Pt 21):5023-34. Epub 2005 Oct 11.


Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.

Krämer DK, Al-Khalili L, Guigas B, Leng Y, Garcia-Roves PM, Krook A.

J Biol Chem. 2007 Jul 6;282(27):19313-20. Epub 2007 May 11.


Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression.

Hutchinson J, Jin J, Cardiff RD, Woodgett JR, Muller WJ.

Mol Cell Biol. 2001 Mar;21(6):2203-12.


Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells.

Liu Y, Wang J, Wu M, Wan W, Sun R, Yang D, Sun X, Ma D, Ying G, Zhang N.

Mol Cancer Res. 2009 Jun;7(6):944-54. doi: 10.1158/1541-7786.MCR-08-0368. Epub 2009 Jun 16.


Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice.

Moorehead RA, Fata JE, Johnson MB, Khokha R.

Cell Death Differ. 2001 Jan;8(1):16-29.


Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression.

Wang D, Wang H, Guo Y, Ning W, Katkuri S, Wahli W, Desvergne B, Dey SK, DuBois RN.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19069-74. Epub 2006 Dec 5.


Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes.

Serrano-Marco L, Rodríguez-Calvo R, El Kochairi I, Palomer X, Michalik L, Wahli W, Vázquez-Carrera M.

Diabetes. 2011 Jul;60(7):1990-9. doi: 10.2337/db10-0704. Epub 2011 May 26.


Protein kinase CK2 in mammary gland tumorigenesis.

Landesman-Bollag E, Romieu-Mourez R, Song DH, Sonenshein GE, Cardiff RD, Seldin DC.

Oncogene. 2001 May 31;20(25):3247-57.


The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells.

Serrano-Marco L, Barroso E, El Kochairi I, Palomer X, Michalik L, Wahli W, Vázquez-Carrera M.

Diabetologia. 2012 Mar;55(3):743-51. doi: 10.1007/s00125-011-2401-4. Epub 2011 Dec 17.


IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.

Guo JP, Coppola D, Cheng JQ.

J Biol Chem. 2011 Oct 28;286(43):37389-98. doi: 10.1074/jbc.M111.287433. Epub 2011 Sep 9.


PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function.

Kleiner S, Nguyen-Tran V, Baré O, Huang X, Spiegelman B, Wu Z.

J Biol Chem. 2009 Jul 10;284(28):18624-33. doi: 10.1074/jbc.M109.008797. Epub 2009 May 12.

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