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Items: 1 to 20 of 153

1.

RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.

Chakir K, Zhu W, Tsang S, Woo AY, Yang D, Wang X, Zeng X, Rhee MH, Mende U, Koitabashi N, Takimoto E, Blumer KJ, Lakatta EG, Kass DA, Xiao RP.

J Mol Cell Cardiol. 2011 Jun;50(6):1000-7. doi: 10.1016/j.yjmcc.2011.01.015. Epub 2011 Feb 1.

2.

Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts.

Xiao RP, Zhang SJ, Chakir K, Avdonin P, Zhu W, Bond RA, Balke CW, Lakatta EG, Cheng H.

Circulation. 2003 Sep 30;108(13):1633-9. Epub 2003 Sep 15.

3.

Gi-biased β2AR signaling links GRK2 upregulation to heart failure.

Zhu W, Petrashevskaya N, Ren S, Zhao A, Chakir K, Gao E, Chuprun JK, Wang Y, Talan M, Dorn GW 2nd, Lakatta EG, Koch WJ, Feldman AM, Xiao RP.

Circ Res. 2012 Jan 20;110(2):265-74. doi: 10.1161/CIRCRESAHA.111.253260. Epub 2011 Dec 15.

4.

RGS2 inhibits beta-adrenergic receptor-induced cardiomyocyte hypertrophy.

Nunn C, Zou MX, Sobiesiak AJ, Roy AA, Kirshenbaum LA, Chidiac P.

Cell Signal. 2010 Aug;22(8):1231-9. doi: 10.1016/j.cellsig.2010.03.015. Epub 2010 Apr 1.

PMID:
20362664
5.
6.

Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes.

Wang Y, De Arcangelis V, Gao X, Ramani B, Jung YS, Xiang Y.

J Biol Chem. 2008 Jan 25;283(4):1799-807. Epub 2007 Dec 3.

7.

Regulation of cardiomyocyte signaling by RGS proteins: differential selectivity towards G proteins and susceptibility to regulation.

Hao J, Michalek C, Zhang W, Zhu M, Xu X, Mende U.

J Mol Cell Cardiol. 2006 Jul;41(1):51-61. Epub 2006 Jun 6.

PMID:
16756988
8.

Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.

Zhang SJ, Cheng H, Zhou YY, Wang DJ, Zhu W, Ziman B, Spurgoen H, Lefkowitz RJ, Lakatta EG, Koch WJ, Xiao RP.

J Biol Chem. 2000 Jul 14;275(28):21773-9.

9.

Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes.

Boivin B, Lavoie C, Vaniotis G, Baragli A, Villeneuve LR, Ethier N, Trieu P, Allen BG, Hébert TE.

Cardiovasc Res. 2006 Jul 1;71(1):69-78. Epub 2006 Mar 24.

10.

β-Adrenergic receptor-PI3K signaling crosstalk in mouse heart: elucidation of immediate downstream signaling cascades.

Zhang W, Yano N, Deng M, Mao Q, Shaw SK, Tseng YT.

PLoS One. 2011;6(10):e26581. doi: 10.1371/journal.pone.0026581. Epub 2011 Oct 19.

11.
12.

Contribution of the extracellular cAMP-adenosine pathway to dual coupling of β2-adrenoceptors to Gs and Gi proteins in mouse skeletal muscle.

Duarte T, Menezes-Rodrigues FS, Godinho RO.

J Pharmacol Exp Ther. 2012 Jun;341(3):820-8. doi: 10.1124/jpet.112.192997. Epub 2012 Mar 21.

13.

Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of β2-adrenoceptor.

Woo AY, Jozwiak K, Toll L, Tanga MJ, Kozocas JA, Jimenez L, Huang Y, Song Y, Plazinska A, Pajak K, Paul RK, Bernier M, Wainer IW, Xiao RP.

J Biol Chem. 2014 Jul 11;289(28):19351-63. doi: 10.1074/jbc.M114.558882. Epub 2014 May 15.

14.

Palmitoylation regulates intracellular trafficking of β2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes.

Liu R, Wang D, Shi Q, Fu Q, Hizon S, Xiang YK.

PLoS One. 2012;7(8):e42658. doi: 10.1371/journal.pone.0042658. Epub 2012 Aug 9.

15.

Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes.

Liu R, Ramani B, Soto D, De Arcangelis V, Xiang Y.

J Biol Chem. 2009 Nov 20;284(47):32279-87. doi: 10.1074/jbc.M109.021428. Epub 2009 Aug 25.

16.

Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy.

Zhang W, Anger T, Su J, Hao J, Xu X, Zhu M, Gach A, Cui L, Liao R, Mende U.

J Biol Chem. 2006 Mar 3;281(9):5811-20. Epub 2005 Dec 26.

17.

cAMP-mediated beta-adrenergic signaling negatively regulates Gq-coupled receptor-mediated fetal gene response in cardiomyocytes.

Patrizio M, Vago V, Musumeci M, Fecchi K, Sposi NM, Mattei E, Catalano L, Stati T, Marano G.

J Mol Cell Cardiol. 2008 Dec;45(6):761-9. doi: 10.1016/j.yjmcc.2008.09.120. Epub 2008 Sep 25.

PMID:
18851973
18.
19.

Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.

Zhu WZ, Zheng M, Koch WJ, Lefkowitz RJ, Kobilka BK, Xiao RP.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1607-12.

20.

Identification of novel competing β2AR phospho-extracellular signal regulated kinase 1/2 signaling pathways in human trabecular meshwork cells.

Hudson BD, Kelly ME.

J Ocul Pharmacol Ther. 2012 Feb;28(1):17-25. doi: 10.1089/jop.2011.0016. Epub 2011 Oct 19.

PMID:
22010988
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