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Items: 1 to 20 of 100

1.

Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase.

Kim S, Kim SF, Maag D, Maxwell MJ, Resnick AC, Juluri KR, Chakraborty A, Koldobskiy MA, Cha SH, Barrow R, Snowman AM, Snyder SH.

Cell Metab. 2011 Feb 2;13(2):215-21. doi: 10.1016/j.cmet.2011.01.007.

2.

Inositol polyphosphate multikinase signaling in the regulation of metabolism.

Lee JY, Kim YR, Park J, Kim S.

Ann N Y Acad Sci. 2012 Oct;1271:68-74. doi: 10.1111/j.1749-6632.2012.06725.x. Review.

3.

Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition.

Dunlop EA, Dodd KM, Seymour LA, Tee AR.

Cell Signal. 2009 Jul;21(7):1073-84. doi: 10.1016/j.cellsig.2009.02.024. Epub 2009 Mar 9.

PMID:
19272448
4.

Inositol polyphosphate multikinase is a coactivator for serum response factor-dependent induction of immediate early genes.

Kim E, Tyagi R, Lee JY, Park J, Kim YR, Beon J, Chen PY, Cha JY, Snyder SH, Kim S.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19938-43. doi: 10.1073/pnas.1320171110. Epub 2013 Nov 18.

5.

Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.

Oshiro N, Rapley J, Avruch J.

J Biol Chem. 2014 Jan 31;289(5):2658-74. doi: 10.1074/jbc.M113.528505. Epub 2013 Dec 11.

6.

GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling.

Stretton C, Hoffmann TM, Munson MJ, Prescott A, Taylor PM, Ganley IG, Hundal HS.

Biochem J. 2015 Sep 1;470(2):207-21. doi: 10.1042/BJ20150404. Epub 2015 Jul 9.

7.

Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.

Maag D, Maxwell MJ, Hardesty DA, Boucher KL, Choudhari N, Hanno AG, Ma JF, Snowman AS, Pietropaoli JW, Xu R, Storm PB, Saiardi A, Snyder SH, Resnick AC.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1391-6. doi: 10.1073/pnas.1017831108. Epub 2011 Jan 10.

8.

Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids.

Averous J, Lambert-Langlais S, Carraro V, Gourbeyre O, Parry L, B'Chir W, Muranishi Y, Jousse C, Bruhat A, Maurin AC, Proud CG, Fafournoux P.

Cell Signal. 2014 Sep;26(9):1918-27. doi: 10.1016/j.cellsig.2014.04.019. Epub 2014 May 2.

PMID:
24793303
9.

Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes.

Pham PT, Heydrick SJ, Fox HL, Kimball SR, Jefferson LS Jr, Lynch CJ.

J Cell Biochem. 2000 Sep 7;79(3):427-41.

PMID:
10972980
10.

Nutrient signaling to mTOR and cell growth.

Jewell JL, Guan KL.

Trends Biochem Sci. 2013 May;38(5):233-42. doi: 10.1016/j.tibs.2013.01.004. Epub 2013 Mar 1. Review.

11.

Nutrient regulation of the mTOR complex 1 signaling pathway.

Kim SG, Buel GR, Blenis J.

Mol Cells. 2013 Jun;35(6):463-73. doi: 10.1007/s10059-013-0138-2. Epub 2013 May 20. Review.

12.

Arginine transcriptional response does not require inositol phosphate synthesis.

Bosch D, Saiardi A.

J Biol Chem. 2012 Nov 2;287(45):38347-55. doi: 10.1074/jbc.M112.384255. Epub 2012 Sep 19.

13.

Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation.

Meyer R, Nalaskowski MM, Ehm P, Schröder C, Naj X, Brehm MA, Mayr GW.

Biol Chem. 2012 Mar;393(3):149-60. doi: 10.1515/hsz-2011-0209.

PMID:
22718630
14.

AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase.

Bang S, Kim S, Dailey MJ, Chen Y, Moran TH, Snyder SH, Kim SF.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):616-20. doi: 10.1073/pnas.1119751109. Epub 2011 Dec 27.

15.

Human cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivation.

Clippinger AJ, Maguire TG, Alwine JC.

J Virol. 2011 Sep;85(18):9369-76. doi: 10.1128/JVI.05102-11. Epub 2011 Jul 6.

16.

Spatial regulation of the mTORC1 system in amino acids sensing pathway.

Suzuki T, Inoki K.

Acta Biochim Biophys Sin (Shanghai). 2011 Sep;43(9):671-9. doi: 10.1093/abbs/gmr066. Epub 2011 Jul 23. Review.

17.

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.

Risson V, Mazelin L, Roceri M, Sanchez H, Moncollin V, Corneloup C, Richard-Bulteau H, Vignaud A, Baas D, Defour A, Freyssenet D, Tanti JF, Le-Marchand-Brustel Y, Ferrier B, Conjard-Duplany A, Romanino K, Bauché S, Hantaï D, Mueller M, Kozma SC, Thomas G, Rüegg MA, Ferry A, Pende M, Bigard X, Koulmann N, Schaeffer L, Gangloff YG.

J Cell Biol. 2009 Dec 14;187(6):859-74. doi: 10.1083/jcb.200903131.

18.

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

Sekulić A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT.

Cancer Res. 2000 Jul 1;60(13):3504-13.

19.

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.

Smith EM, Finn SG, Tee AR, Browne GJ, Proud CG.

J Biol Chem. 2005 May 13;280(19):18717-27. Epub 2005 Mar 16.

20.

Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction.

Hong-Brown LQ, Brown CR, Kazi AA, Huber DS, Pruznak AM, Lang CH.

J Cell Biochem. 2010 Apr 15;109(6):1172-84. doi: 10.1002/jcb.22496.

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