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SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts.

Renga B, Mencarelli A, Migliorati M, Cipriani S, D'Amore C, Distrutti E, Fiorucci S.

Inflamm Res. 2011 Jun;60(6):577-87. doi: 10.1007/s00011-010-0306-1. Epub 2011 Jan 29.


Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis.

Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Morelli A, Pruzanski M, Pellicciari R.

J Pharmacol Exp Ther. 2005 Oct;315(1):58-68. Epub 2005 Jun 24.


Antiatherosclerotic effect of farnesoid X receptor.

Mencarelli A, Renga B, Distrutti E, Fiorucci S.

Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H272-81. doi: 10.1152/ajpheart.01075.2008. Epub 2008 Nov 21.


The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis.

Fiorucci S, Antonelli E, Rizzo G, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pellicciari R, Morelli A.

Gastroenterology. 2004 Nov;127(5):1497-512.


Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells.

Morán-Salvador E, Titos E, Rius B, González-Périz A, García-Alonso V, López-Vicario C, Miquel R, Barak Y, Arroyo V, Clària J.

J Hepatol. 2013 Nov;59(5):1045-53. doi: 10.1016/j.jhep.2013.06.023. Epub 2013 Jul 2.


A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis.

Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pruzanski M, Morelli A, Pellicciari R.

J Pharmacol Exp Ther. 2005 Aug;314(2):584-95. Epub 2005 Apr 28.


Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.

Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B.

Mol Endocrinol. 2003 Feb;17(2):259-72.


Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration.

Li YT, Swales KE, Thomas GJ, Warner TD, Bishop-Bailey D.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2606-11.


The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner.

Kanaya E, Shiraki T, Jingami H.

Biochem J. 2004 Sep 15;382(Pt 3):913-21.


Peroxisome proliferator-activated receptors and hepatic stellate cell activation.

Miyahara T, Schrum L, Rippe R, Xiong S, Yee HF Jr, Motomura K, Anania FA, Willson TM, Tsukamoto H.

J Biol Chem. 2000 Nov 17;275(46):35715-22.


Repression of farnesoid X receptor during the acute phase response.

Kim MS, Shigenaga J, Moser A, Feingold K, Grunfeld C.

J Biol Chem. 2003 Mar 14;278(11):8988-95. Epub 2003 Jan 7.


The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo.

Rizzo G, Disante M, Mencarelli A, Renga B, Gioiello A, Pellicciari R, Fiorucci S.

Mol Pharmacol. 2006 Oct;70(4):1164-73. Epub 2006 Jun 15.


Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice.

Da Silva Morais A, Abarca-Quinones J, Horsmans Y, Stärkel P, Leclercq IA.

Int J Mol Med. 2007 Jan;19(1):105-12.


The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis.

Mencarelli A, Renga B, Migliorati M, Cipriani S, Distrutti E, Santucci L, Fiorucci S.

J Immunol. 2009 Nov 15;183(10):6657-66. doi: 10.4049/jimmunol.0901347. Epub 2009 Oct 30.


Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.

Catalano S, Malivindi R, Giordano C, Gu G, Panza S, Bonofiglio D, Lanzino M, Sisci D, Panno ML, Andò S.

J Biol Chem. 2010 Feb 19;285(8):5581-93. doi: 10.1074/jbc.M109.052670. Epub 2009 Dec 21.


Selective inhibition of activated stellate cells and protection from carbon tetrachloride-induced liver injury in rats by a new PPARgamma agonist KR62776.

Bae MA, Rhee SD, Jung WH, Ahn JH, Song BJ, Cheon HG.

Arch Pharm Res. 2010 Mar;33(3):433-42. doi: 10.1007/s12272-010-0313-3. Epub 2010 Mar 30.


Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes.

Qin P, Borges-Marcucci LA, Evans MJ, Harnish DC.

Am J Physiol Gastrointest Liver Physiol. 2005 Aug;289(2):G267-73. Epub 2005 Apr 7.

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