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21276815,23990350,18280761,23495860,21740451,25445928,20678680,29206637,27817816,20233915,19637942,21334553,15537472,20496301,17530506,18044682,26194120,26089659,20528601,21942463,30715829,25774769,20501985,23719639,24802656,17314337,18398787,26158649,17969568,21714776,18803985,16457807,20508579,15922813,23409722,23389862,18484216,25226477,26194213,26503392,19644045,27452453,15923248,25563342,30214177,27003559,20705441,16199151,23651802,21037960,17905575,22902134,24070494,21659855,20082059,27254954,29116901,25537556,14627180,32977747,18940948,22003292,29183382,12493336,15038079,23898819,19479397,21521133,32985094,23042705,20369715,16008004,16932963,15579052,25280465,32179613,17240618,26648711,29216852,22035511,15748094,19011503,25044280,26082629,30707637,16156676,29120273,34464242,27107490,30261996,23147985,26799347,26316169,32597259,29505318,31202120,21702649,27046366,25462534,23583567,30509701,18007544,15124043,26113207,19633090,27382276,26585433,24152210,26172630,22985270,21271481,26298024,23920253,20381630,21554238,28395575,29026296,15624197,31576115,15249466,30190269,16463710,16757394,26019099,28203071,23551021,29503539,28255905,28057707,20816832,30290801,27855451,23445751,19489193,27993284,30216731,24138334,28117615,27877031,31629940,26917956,14586509,28883469,27585383,23415574,26514912,28868931,31813679,23472632,30261979,33204085,19140566,25540900,26855301,15878389,26559079,22982023,31922913,25552883,30498340,22453538,26695682,27215595,24940053,25746966,31567741,23274274,20406080,28745524,25274453,24429159,26022947,19505986,31852408,21045758,22007673,29410364,24669979,26378450,15021180,32278779,21357659,24194824,24247039,28406337,15124042,25003907,29474807,29089754,25407604,28358398,23037719,34081722,25596991,24392807,18162137,34126054,25051662,17356080,25099256,25597386,34569408,31298938,27787709,26893311,28714745,26758585,32960872,29943812,25409118,24920884,21702714,23744364,27692139,24934041,21396667,24675239,14720023,31354256,23574107,28617814,35385359,29549687,23749841,18568840,22526864,31762414,25471093,33829619,27153510,22546485,29417739,27430907,31564847,36539784,25038591,23962341,15572556,22782274,30339858,35769224,30498343,21334552,31806954,24795909,31190791,30545961,34858023,17356119,29440882,21512168,30608978,16105731,35325585,19484677,30233168,26752024,24909304,31659161,19200689,32643439,23242950,24568285,18453363,25446566,20714372,23872948,26297533,24429112,12737679,29412688,15132963,23836970,25629143,23971870,24669382,22966886,29783858,25293857,18460518,31549299,31899652,29938633,20413535,26343938,26496284,21453221,31621329,26392770,26935750,33115481,16359896,36974273,32800200,19740259,26559107,25240963,24824384,17595597,35899144,27724847,23135217,24670577,31537701,17406181,31195812,36342141,17380589,29605621,12608439,29949485,26794033,32021138,23256718,30358366,26848017,30287432,31076058,25417481,32366483,15302775,19218654,33314947,23590264,31576118,36503112,21838890,16963650,28760570,32479149,26655798,33149113,32098727,24810285,34615691,24130228,27418383,30895590,23079688,28840400,35897707,31334840,18956992,21811461,32649216,26521271,35435466,34385098,33454710,28214911,18568843,23989678,28931659,29679596,31286970,18046857,2186237,24040908,28801320,30956205,9612667,36830583,25557156,17185647,29903607,19926996,29229101,21589948,32972982,26051430,26110239,20075705,33446577,35843928,19716946,24127377,24176996,35379390,25212953,31022961,12712224,20156737,30507646,27761973,8096208,19684862,21853640,31358491,34446524,36979411,31443653,29884817,24751857,32648518,34697964,23323609,28686388,32941462,30200965,32239604,25417480,34789465,17361504,30326817,25603004,35887686,26289362,25603005,21079266,28137503,12851248,26086323,31462509,15303640,20591200,35027472,18176665,27684954,29467200,28186150,36458847,28716642,24144851,27651909,6142449,25217077,23923299,30846474,27149812,24474237,27257014,27154992,18296470,33893068,28722373,17311843,34000507,25359339,30925849,26841181,16877694,30335235,32699712,24475658,25674175,24244086,29796008,29741897,21394429,30587083,33678268,19734352,20551414,26578157,37091940,23529709,23456564,23189102,31317927,23139018,18510885,3550768,32505315,8901323,29921178,36949977,9118715,24708470,27234389,26206051,27998420,31488588,31488585,29962118,25269946,23514258,27323704,15302767,25962834,33655817,14769498,1458140,16755084,34033036,22351738,28246430,29629399,31691125,36485238[uid]

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The use of long acting β₂-agonists, alone or in combination with inhaled corticosteroids, in chronic obstructive pulmonary disease (COPD): a risk-benefit analysis.

Cave AC, Hurst MM. Cave AC, et al. Pharmacol Ther. 2011 May;130(2):114-43. doi: 10.1016/j.pharmthera.2010.12.008. Epub 2011 Jan 27. Pharmacol Ther. 2011. PMID: 21276815 Review.

Combined corticosteroid and long-acting beta(2)-agonist in one inhaler versus inhaled corticosteroids alone for chronic obstructive pulmonary disease.

Nannini LJ, Poole P, Milan SJ, Kesterton A. Nannini LJ, et al. Cochrane Database Syst Rev. 2013 Aug 30;2013(8):CD006826. doi: 10.1002/14651858.CD006826.pub2. Cochrane Database Syst Rev. 2013. PMID: 23990350 Free PMC article. Review.

The impact of inhaled corticosteroid and long-acting beta-agonist combination therapy on outcomes in COPD.

Hanania NA. Hanania NA. Pulm Pharmacol Ther. 2008;21(3):540-50. doi: 10.1016/j.pupt.2007.12.004. Epub 2008 Jan 6. Pulm Pharmacol Ther. 2008. PMID: 18280761 Review.

Combination of budesonide/formoterol more effective than fluticasone/salmeterol in preventing exacerbations in chronic obstructive pulmonary disease: the PATHOS study.

Larsson K, Janson C, Lisspers K, Jørgensen L, Stratelis G, Telg G, Ställberg B, Johansson G. Larsson K, et al. J Intern Med. 2013 Jun;273(6):584-94. doi: 10.1111/joim.12067. Epub 2013 Apr 1. J Intern Med. 2013. PMID: 23495860 Free article.

Effect of long-acting beta-agonists on the frequency of COPD exacerbations: a meta-analysis.

Wang J, Nie B, Xiong W, Xu Y. Wang J, et al. J Clin Pharm Ther. 2012 Apr;37(2):204-11. doi: 10.1111/j.1365-2710.2011.01285.x. Epub 2011 Jul 11. J Clin Pharm Ther. 2012. PMID: 21740451 Review.

Differences in the efficacy and safety among inhaled corticosteroids (ICS)/long-acting beta2-agonists (LABA) combinations in the treatment of chronic obstructive pulmonary disease (COPD): Role of ICS.

Latorre M, Novelli F, Vagaggini B, Braido F, Papi A, Sanduzzi A, Santus P, Scichilone N, Paggiaro P. Latorre M, et al. Pulm Pharmacol Ther. 2015 Feb;30:44-50. doi: 10.1016/j.pupt.2014.10.006. Epub 2014 Nov 6. Pulm Pharmacol Ther. 2015. PMID: 25445928 Free article. Review.

Relative effectiveness of budesonide/formoterol and fluticasone propionate/salmeterol in a 1-year, population-based, matched cohort study of patients with chronic obstructive pulmonary disease (COPD): Effect on COPD-related exacerbations, emergency department visits and hospitalizations, medication utilization, and treatment adherence.

Blais L, Forget A, Ramachandran S. Blais L, et al. Clin Ther. 2010 Jul;32(7):1320-8. doi: 10.1016/j.clinthera.2010.06.022. Clin Ther. 2010. PMID: 20678680

Effects of inhaled corticosteroids /long-acting agonists in a single inhaler versus inhaled corticosteroids alone on all-cause mortality, pneumonia, and fracture in chronic obstructive pulmonary disease: A nationwide cohort study 2002-2013.

Cho KH, Kim YS, Linton JA, Nam CM, Choi Y, Park EC. Cho KH, et al. Respir Med. 2017 Sep;130:75-84. doi: 10.1016/j.rmed.2017.07.012. Epub 2017 Jul 19. Respir Med. 2017. PMID: 29206637 Free article.

Incidence of oral thrush in patients with COPD prescribed inhaled corticosteroids: Effect of drug, dose, and device.

Dekhuijzen PNR, Batsiou M, Bjermer L, Bosnic-Anticevich S, Chrystyn H, Papi A, Rodríguez-Roisin R, Fletcher M, Wood L, Cifra A, Soriano JB, Price DB. Dekhuijzen PNR, et al. Respir Med. 2016 Nov;120:54-63. doi: 10.1016/j.rmed.2016.09.015. Epub 2016 Sep 22. Respir Med. 2016. PMID: 27817816 Free article.

Effects of inhaled corticosteroids in monotherapy or combined with long-acting {beta}2-agonists on mortality among patients with chronic obstructive pulmonary disease.

Cyr MC, Beauchesne MF, Lemière C, Aaron SD, Blais L. Cyr MC, et al. Ann Pharmacother. 2010 Apr;44(4):613-22. doi: 10.1345/aph.1M243. Epub 2010 Mar 16. Ann Pharmacother. 2010. PMID: 20233915

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