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Results: 1 to 20 of 150

1.

LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity.

Meehan AM, Saenz DT, Morrison J, Hu C, Peretz M, Poeschla EM.

J Virol. 2011 Apr;85(7):3570-83. doi: 10.1128/JVI.01295-10. Epub 2011 Jan 26.

PMID:
21270171
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors.

Meehan AM, Saenz DT, Morrison JH, Garcia-Rivera JA, Peretz M, Llano M, Poeschla EM.

PLoS Pathog. 2009 Jul;5(7):e1000522. doi: 10.1371/journal.ppat.1000522. Epub 2009 Jul 17.

PMID:
19609362
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs.

Schrijvers R, De Rijck J, Demeulemeester J, Adachi N, Vets S, Ronen K, Christ F, Bushman FD, Debyser Z, Gijsbers R.

PLoS Pathog. 2012;8(3):e1002558. doi: 10.1371/journal.ppat.1002558. Epub 2012 Mar 1.

PMID:
22396646
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

An essential role for LEDGF/p75 in HIV integration.

Llano M, Saenz DT, Meehan A, Wongthida P, Peretz M, Walker WH, Teo W, Poeschla EM.

Science. 2006 Oct 20;314(5798):461-4. Epub 2006 Sep 7.

PMID:
16959972
[PubMed - indexed for MEDLINE]
Free Article
5.

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus.

Vandekerckhove L, Christ F, Van Maele B, De Rijck J, Gijsbers R, Van den Haute C, Witvrouw M, Debyser Z.

J Virol. 2006 Feb;80(4):1886-96.

PMID:
16439544
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

Hombrouck A, De Rijck J, Hendrix J, Vandekerckhove L, Voet A, De Maeyer M, Witvrouw M, Engelborghs Y, Christ F, Gijsbers R, Debyser Z.

PLoS Pathog. 2007 Mar;3(3):e47.

PMID:
17397262
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.

Vanegas M, Llano M, Delgado S, Thompson D, Peretz M, Poeschla E.

J Cell Sci. 2005 Apr 15;118(Pt 8):1733-43. Epub 2005 Mar 29.

PMID:
15797927
[PubMed - indexed for MEDLINE]
Free Article
8.

Structural and functional role of INI1 and LEDGF in the HIV-1 preintegration complex.

Maillot B, Lévy N, Eiler S, Crucifix C, Granger F, Richert L, Didier P, Godet J, Pradeau-Aubreton K, Emiliani S, Nazabal A, Lesbats P, Parissi V, Mely Y, Moras D, Schultz P, Ruff M.

PLoS One. 2013 Apr 11;8(4):e60734. doi: 10.1371/journal.pone.0060734. Print 2013.

PMID:
23593299
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.

Maertens G, Cherepanov P, Pluymers W, Busschots K, De Clercq E, Debyser Z, Engelborghs Y.

J Biol Chem. 2003 Aug 29;278(35):33528-39. Epub 2003 Jun 9.

PMID:
12796494
[PubMed - indexed for MEDLINE]
Free Article
10.

Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase.

Zheng Y, Ao Z, Jayappa KD, Yao X.

Virol J. 2010 Mar 23;7:68. doi: 10.1186/1743-422X-7-68.

PMID:
20331877
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication.

De Rijck J, Vandekerckhove L, Gijsbers R, Hombrouck A, Hendrix J, Vercammen J, Engelborghs Y, Christ F, Debyser Z.

J Virol. 2006 Dec;80(23):11498-509. Epub 2006 Sep 20.

PMID:
16987986
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.

Le Rouzic E, Bonnard D, Chasset S, Bruneau JM, Chevreuil F, Le Strat F, Nguyen J, Beauvoir R, Amadori C, Brias J, Vomscheid S, Eiler S, Lévy N, Delelis O, Deprez E, Saïb A, Zamborlini A, Emiliani S, Ruff M, Ledoussal B, Moreau F, Benarous R.

Retrovirology. 2013 Nov 21;10:144. doi: 10.1186/1742-4690-10-144.

PMID:
24261564
[PubMed - indexed for MEDLINE]
Free Article
13.

Identification of the LEDGF/p75 binding site in HIV-1 integrase.

Busschots K, Voet A, De Maeyer M, Rain JC, Emiliani S, Benarous R, Desender L, Debyser Z, Christ F.

J Mol Biol. 2007 Feb 2;365(5):1480-92. Epub 2006 Nov 3.

PMID:
17137594
[PubMed - indexed for MEDLINE]
14.

Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells.

Balakrishnan M, Yant SR, Tsai L, O'Sullivan C, Bam RA, Tsai A, Niedziela-Majka A, Stray KM, Sakowicz R, Cihlar T.

PLoS One. 2013 Sep 9;8(9):e74163. doi: 10.1371/journal.pone.0074163. eCollection 2013.

PMID:
24040198
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

Bartholomeeusen K, De Rijck J, Busschots K, Desender L, Gijsbers R, Emiliani S, Benarous R, Debyser Z, Christ F.

J Mol Biol. 2007 Sep 14;372(2):407-21. Epub 2007 Jul 12.

PMID:
17669426
[PubMed - indexed for MEDLINE]
16.

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.

Jurado KA, Wang H, Slaughter A, Feng L, Kessl JJ, Koh Y, Wang W, Ballandras-Colas A, Patel PA, Fuchs JR, Kvaratskhelia M, Engelman A.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8690-5. doi: 10.1073/pnas.1300703110. Epub 2013 Apr 22.

PMID:
23610442
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

TALEN Knockout of the PSIP1 Gene in Human cells: Analyses of HIV-1 Replication and Allosteric Integrase Inhibitor Mechanism.

Fadel HJ, Morrison JH, Saenz DT, Fuchs JR, Kvaratskhelia M, Ekker SC, Poeschla EM.

J Virol. 2014 Jun 18. pii: JVI.01397-14. [Epub ahead of print]

PMID:
24942577
[PubMed - as supplied by publisher]
18.

Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells.

Levin A, Hayouka Z, Friedler A, Loyter A.

Virol J. 2010 Aug 2;7:177. doi: 10.1186/1743-422X-7-177.

PMID:
20678206
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.

Llano M, Vanegas M, Hutchins N, Thompson D, Delgado S, Poeschla EM.

J Mol Biol. 2006 Jul 21;360(4):760-73. Epub 2006 May 17.

PMID:
16793062
[PubMed - indexed for MEDLINE]
20.

A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75.

Hare S, Shun MC, Gupta SS, Valkov E, Engelman A, Cherepanov P.

PLoS Pathog. 2009 Jan;5(1):e1000259. doi: 10.1371/journal.ppat.1000259. Epub 2009 Jan 9.

PMID:
19132083
[PubMed - indexed for MEDLINE]
Free PMC Article

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