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Impact of withholding early parenteral nutrition completing enteral nutrition in pediatric critically ill patients (PEPaNIC trial): study protocol for a randomized controlled trial.

Fivez T, Kerklaan D, Verbruggen S, Vanhorebeek I, Verstraete S, Tibboel D, Guerra GG, Wouters PJ, Joffe A, Joosten K, Mesotten D, Van den Berghe G.

Trials. 2015 May 1;16:202. doi: 10.1186/s13063-015-0728-8.


Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients.

Heyland DK, Dhaliwal R, Drover JW, Gramlich L, Dodek P; Canadian Critical Care Clinical Practice Guidelines Committee.

JPEN J Parenter Enteral Nutr. 2003 Sep-Oct;27(5):355-73.


Impact of early enteral versus parenteral nutrition on mortality in patients requiring mechanical ventilation and catecholamines: study protocol for a randomized controlled trial (NUTRIREA-2).

Brisard L, Le Gouge A, Lascarrou JB, Dupont H, Asfar P, Sirodot M, Piton G, Bui HN, Gontier O, Hssain AA, Gaudry S, Rigaud JP, Quenot JP, Maxime V, Schwebel C, Thévenin D, Nseir S, Parmentier E, El Kalioubie A, Jourdain M, Leray V, Rolin N, Bellec F, Das V, Ganster F, Guitton C, Asehnoune K, Bretagnol A, Anguel N, Mira JP, Canet E, Guidet B, Djibre M, Misset B, Robert R, Martino F, Letocart P, Silva D, Darmon M, Botoc V, Herbrecht JE, Meziani F, Devaquet J, Mercier E, Richecoeur J, Martin S, Gréau E, Giraudeau B, Reignier J.

Trials. 2014 Dec 23;15:507. doi: 10.1186/1745-6215-15-507.


Early versus late parenteral nutrition in critically ill adults.

Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G, Van Cromphaut S, Ingels C, Meersseman P, Muller J, Vlasselaers D, Debaveye Y, Desmet L, Dubois J, Van Assche A, Vanderheyden S, Wilmer A, Van den Berghe G.

N Engl J Med. 2011 Aug 11;365(6):506-17. doi: 10.1056/NEJMoa1102662. Epub 2011 Jun 29.


When early enteral feeding is not possible in critically ill patients: results of a multicenter observational study.

Cahill NE, Murch L, Jeejeebhoy K, McClave SA, Day AG, Wang M, Heyland DK.

JPEN J Parenter Enteral Nutr. 2011 Mar;35(2):160-8. doi: 10.1177/0148607110381405.


Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial.

Doig GS, Simpson F, Sweetman EA, Finfer SR, Cooper DJ, Heighes PT, Davies AR, O'Leary M, Solano T, Peake S; Early PN Investigators of the ANZICS Clinical Trials Group.

JAMA. 2013 May 22;309(20):2130-8. doi: 10.1001/jama.2013.5124.


Permissive underfeeding versus target enteral feeding in adult critically ill patients (PermiT Trial): a study protocol of a multicenter randomized controlled trial.

Arabi YM, Haddad SH, Aldawood AS, Al-Dorzi HM, Tamim HM, Sakkijha M, Jones G, McIntyre L, Mehta S, Solaiman O, Sadat M, Afesh L, Sami B.

Trials. 2012 Oct 12;13:191. doi: 10.1186/1745-6215-13-191.


Role of disease and macronutrient dose in the randomized controlled EPaNIC trial: a post hoc analysis.

Casaer MP, Wilmer A, Hermans G, Wouters PJ, Mesotten D, Van den Berghe G.

Am J Respir Crit Care Med. 2013 Feb 1;187(3):247-55. doi: 10.1164/rccm.201206-0999OC. Epub 2012 Nov 29.


Combined enteral and parenteral nutrition.

Wernerman J.

Curr Opin Clin Nutr Metab Care. 2012 Mar;15(2):161-5. doi: 10.1097/MCO.0b013e32835036a9. Review.


Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial.

Hermans G, Casaer MP, Clerckx B, Güiza F, Vanhullebusch T, Derde S, Meersseman P, Derese I, Mesotten D, Wouters PJ, Van Cromphaut S, Debaveye Y, Gosselink R, Gunst J, Wilmer A, Van den Berghe G, Vanhorebeek I.

Lancet Respir Med. 2013 Oct;1(8):621-9. doi: 10.1016/S2213-2600(13)70183-8. Epub 2013 Sep 10.


Reconciling divergent results of the latest parenteral nutrition studies in the ICU.

Singer P, Pichard C.

Curr Opin Clin Nutr Metab Care. 2013 Mar;16(2):187-93. doi: 10.1097/MCO.0b013e32835c34be. Review.


Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients? A systematic review of the literature.

Gramlich L, Kichian K, Pinilla J, Rodych NJ, Dhaliwal R, Heyland DK.

Nutrition. 2004 Oct;20(10):843-8. Review.


Is it now time to promote mixed enteral and parenteral nutrition for the critically ill patient?

Heidegger CP, Romand JA, Treggiari MM, Pichard C.

Intensive Care Med. 2007 Jun;33(6):963-9. Epub 2007 Apr 28.


Supplemental parenteral nutrition in critically ill patients: a study protocol for a phase II randomised controlled trial.

Ridley EJ, Davies AR, Parke R, Bailey M, McArthur C, Gillanders L, Cooper DJ, McGuinness S; Supplemental Parenteral Nutrition Clinical Investigators.

Trials. 2015 Dec 24;16:587. doi: 10.1186/s13063-015-1118-y.


Early enteral immunonutrition vs. parenteral nutrition in critically ill patients without severe sepsis: a randomized clinical trial.

Radrizzani D, Bertolini G, Facchini R, Simini B, Bruzzone P, Zanforlin G, Tognoni G, Iapichino G.

Intensive Care Med. 2006 Aug;32(8):1191-8. Epub 2006 Jun 21.


Evaluation of over- and underfeeding following the introduction of a protocol for weaning from parenteral to enteral nutrition in the intensive care unit.

Dervan N, Dowsett J, Gleeson E, Carr S, Corish C.

Nutr Clin Pract. 2012 Dec;27(6):781-7. doi: 10.1177/0884533612462899. Epub 2012 Oct 16.

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