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Items: 1 to 20 of 97

1.

Evaluation of mutations in the isocitrate dehydrogenase genes in therapy-related and secondary acute myeloid leukaemia identifies a patient with clonal evolution to IDH2 R172K homozygosity due to uniparental disomy.

Pichler MM, Bodner C, Fischer C, Deutsch AJ, Hiden K, Beham-Schmid C, Linkesch W, Guelly C, Sill H, Wölfler A.

Br J Haematol. 2011 Mar;152(5):669-72. doi: 10.1111/j.1365-2141.2010.08404.x. Epub 2011 Jan 20. No abstract available.

PMID:
21250968
2.

Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value.

Abbas S, Lugthart S, Kavelaars FG, Schelen A, Koenders JE, Zeilemaker A, van Putten WJ, Rijneveld AW, Löwenberg B, Valk PJ.

Blood. 2010 Sep 23;116(12):2122-6. doi: 10.1182/blood-2009-11-250878. Epub 2010 Jun 10.

3.

IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication.

Paschka P, Schlenk RF, Gaidzik VI, Habdank M, Krönke J, Bullinger L, Späth D, Kayser S, Zucknick M, Götze K, Horst HA, Germing U, Döhner H, Döhner K.

J Clin Oncol. 2010 Aug 1;28(22):3636-43. doi: 10.1200/JCO.2010.28.3762. Epub 2010 Jun 21.

4.

Rapid detection of IDH2 (R140Q and R172K) mutations in acute myeloid leukemia.

Ashraf S, Noguera NI, Di Giandomenico J, Zaza S, Hasan SK, Lo-Coco F.

Ann Hematol. 2013 Oct;92(10):1319-23. doi: 10.1007/s00277-013-1868-0. Epub 2013 Aug 15.

PMID:
23949315
5.

[Isocitrate dehydrogenase gene mutations in acute myeloid leukemia].

Zhou XJ, Zhang SJ, Qiao C, Shen YF, Li JY.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Aug;19(4):902-6. Chinese.

PMID:
21867611
6.

[Clinical significance of IDH1 and IDH2 mutations in patients with acute myeloid leukemia].

Mi RH, Lu XD, Wei XD, Fan RH, Yin QS, Hu JY, Wang Q, Song YP.

Zhonghua Xue Ye Xue Za Zhi. 2011 Sep;32(9):610-3. Chinese.

PMID:
22338155
7.

Increased levels of 2-hydroxyglutarate in AML patients with IDH1-R132H and IDH2-R140Q mutations.

Sellner L, Capper D, Meyer J, Langhans CD, Hartog CM, Pfeifer H, Serve H, Ho AD, Okun JG, Krämer A, Von Deimling A.

Eur J Haematol. 2010 Nov;85(5):457-9. doi: 10.1111/j.1600-0609.2010.01505.x. No abstract available.

PMID:
20659156
8.

IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders.

Zou Y, Zeng Y, Zhang DF, Zou SH, Cheng YF, Yao YG.

Biochem Biophys Res Commun. 2010 Nov 12;402(2):378-83. doi: 10.1016/j.bbrc.2010.10.038. Epub 2010 Oct 12.

PMID:
20946881
9.

Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia.

Fried I, Bodner C, Pichler MM, Lind K, Beham-Schmid C, Quehenberger F, Sperr WR, Linkesch W, Sill H, Wölfler A.

Haematologica. 2012 Feb;97(2):246-50. doi: 10.3324/haematol.2011.051581. Epub 2011 Oct 11.

10.

[Detection of the IDH1 gene mutation in acute myeloid leukemia by PCR-high resolution melting analysis].

Lin J, Qian J, Yao DM.

Zhonghua Xue Ye Xue Za Zhi. 2011 Jul;32(7):484-6. Chinese. No abstract available.

PMID:
22213873
11.

Rapid identification of IDH1 and IDH2 mutations in acute myeloid leukaemia using high resolution melting curve analysis.

Noordermeer SM, Tönnissen E, Vissers I, van der Heijden A, van de Locht LT, Deutz-Terlouw PP, Marijt EW, Jansen JH, van der Reijden BA.

Br J Haematol. 2011 Feb;152(4):493-6. doi: 10.1111/j.1365-2141.2010.08423.x. Epub 2010 Oct 19. No abstract available.

PMID:
20955413
12.

Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group.

Boissel N, Nibourel O, Renneville A, Gardin C, Reman O, Contentin N, Bordessoule D, Pautas C, de Revel T, Quesnel B, Huchette P, Philippe N, Geffroy S, Terre C, Thomas X, Castaigne S, Dombret H, Preudhomme C.

J Clin Oncol. 2010 Aug 10;28(23):3717-23. doi: 10.1200/JCO.2010.28.2285. Epub 2010 Jul 12.

13.

IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status.

Jeziskova I, Razga F, Bajerova M, Racil Z, Mayer J, Dvorakova D.

Leuk Lymphoma. 2010 Dec;51(12):2285-7. doi: 10.3109/10428194.2010.523126. Epub 2010 Oct 7. No abstract available.

PMID:
20929327
14.

Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia.

Thol F, Damm F, Wagner K, Göhring G, Schlegelberger B, Hoelzer D, Lübbert M, Heit W, Kanz L, Schlimok G, Raghavachar A, Fiedler W, Kirchner H, Heil G, Heuser M, Krauter J, Ganser A.

Blood. 2010 Jul 29;116(4):614-6. doi: 10.1182/blood-2010-03-272146. Epub 2010 Apr 26.

15.

Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia.

Raghavan M, Smith LL, Lillington DM, Chaplin T, Kakkas I, Molloy G, Chelala C, Cazier JB, Cavenagh JD, Fitzgibbon J, Lister TA, Young BD.

Blood. 2008 Aug 1;112(3):814-21. doi: 10.1182/blood-2008-01-132431. Epub 2008 May 19.

16.

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.

Gross S, Cairns RA, Minden MD, Driggers EM, Bittinger MA, Jang HG, Sasaki M, Jin S, Schenkein DP, Su SM, Dang L, Fantin VR, Mak TW.

J Exp Med. 2010 Feb 15;207(2):339-44. doi: 10.1084/jem.20092506. Epub 2010 Feb 8.

17.

High incidence of IDH mutations in acute myeloid leukaemia with cuplike nuclei.

Rakheja D, Konoplev S, Su M, Wheeler D, Muzny DM, Ruvolo VR, Collins R, Karandikar NJ, Andreeff M, Medeiros LJ, Chen W.

Br J Haematol. 2011 Oct;155(1):125-8. doi: 10.1111/j.1365-2141.2011.08646.x. Epub 2011 Apr 12. No abstract available.

PMID:
21480859
18.

Correlation between IDH2 mutations and disease status in acute myeloid leukemia.

Eklund EA, Raychaudhuri P, Platanias LC.

Leuk Lymphoma. 2010 Dec;51(12):2157-8. doi: 10.3109/10428194.2010.525271. Epub 2010 Oct 7. No abstract available.

PMID:
20929316
19.

IDH1 and IDH2 mutations in therapy-related myelodysplastic syndrome and acute myeloid leukemia are associated with a normal karyotype and with der(1;7)(q10;p10).

Westman MK, Pedersen-Bjergaard J, Andersen MT, Andersen MK.

Leukemia. 2013 Apr;27(4):957-9. doi: 10.1038/leu.2012.347. Epub 2012 Nov 29. No abstract available.

PMID:
23192014
20.

IDH mutations in glioma and acute myeloid leukemia.

Dang L, Jin S, Su SM.

Trends Mol Med. 2010 Sep;16(9):387-97. doi: 10.1016/j.molmed.2010.07.002. Epub 2010 Aug 5. Review.

PMID:
20692206
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