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Items: 1 to 20 of 99


Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal.

Peyrot des Gachons C, Uchida K, Bryant B, Shima A, Sperry JB, Dankulich-Nagrudny L, Tominaga M, Smith AB 3rd, Beauchamp GK, Breslin PA.

J Neurosci. 2011 Jan 19;31(3):999-1009. doi: 10.1523/JNEUROSCI.1374-10.2011.


Differences in the chemesthetic subqualities of capsaicin, ibuprofen, and olive oil.

Bennett SM, Hayes JE.

Chem Senses. 2012 Jun;37(5):471-8. doi: 10.1093/chemse/bjr129. Epub 2012 Jan 25.


Sensory characterization of the irritant properties of oleocanthal, a natural anti-inflammatory agent in extra virgin olive oils.

Cicerale S, Breslin PA, Beauchamp GK, Keast RS.

Chem Senses. 2009 May;34(4):333-9. doi: 10.1093/chemse/bjp006. Epub 2009 Mar 8.


The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6.

de la Roche J, Eberhardt MJ, Klinger AB, Stanslowsky N, Wegner F, Koppert W, Reeh PW, Lampert A, Fischer MJ, Leffler A.

J Biol Chem. 2013 Jul 12;288(28):20280-92. doi: 10.1074/jbc.M113.479337. Epub 2013 May 24.


TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons.

Anand U, Otto WR, Facer P, Zebda N, Selmer I, Gunthorpe MJ, Chessell IP, Sinisi M, Birch R, Anand P.

Neurosci Lett. 2008 Jun 20;438(2):221-7. doi: 10.1016/j.neulet.2008.04.007. Epub 2008 Apr 8.


Influence of heat on biological activity and concentration of oleocanthal--a natural anti-inflammatory agent in virgin olive oil.

Cicerale S, Conlan XA, Barnett NW, Sinclair AJ, Keast RS.

J Agric Food Chem. 2009 Feb 25;57(4):1326-30. doi: 10.1021/jf803154w.


Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer's disease: in vitro and in vivo studies.

Abuznait AH, Qosa H, Busnena BA, El Sayed KA, Kaddoumi A.

ACS Chem Neurosci. 2013 Jun 19;4(6):973-82. doi: 10.1021/cn400024q. Epub 2013 Feb 25.


Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner.

Komatsu T, Uchida K, Fujita F, Zhou Y, Tominaga M.

Pflugers Arch. 2012 Apr;463(4):549-59. doi: 10.1007/s00424-011-1069-4. Epub 2012 Jan 6.


Benzoquinone reveals a cysteine-dependent desensitization mechanism of TRPA1.

Ibarra Y, Blair NT.

Mol Pharmacol. 2013 May;83(5):1120-32. doi: 10.1124/mol.112.084194. Epub 2013 Mar 11.


Activation of transient receptor potential ankyrin 1 by eugenol.

Chung G, Im ST, Kim YH, Jung SJ, Rhyu MR, Oh SB.

Neuroscience. 2014 Mar 7;261:153-60. doi: 10.1016/j.neuroscience.2013.12.047. Epub 2013 Dec 30.


Stimulation of human TRPA1 channels by clinical concentrations of the antirheumatic drug auranofin.

Hatano N, Suzuki H, Muraki Y, Muraki K.

Am J Physiol Cell Physiol. 2013 Feb 15;304(4):C354-61. doi: 10.1152/ajpcell.00096.2012. Epub 2012 Dec 5.


TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo.

Alenmyr L, Herrmann A, Högestätt ED, Greiff L, Zygmunt PM.

Clin Physiol Funct Imaging. 2011 Nov;31(6):435-44. doi: 10.1111/j.1475-097X.2011.01039.x. Epub 2011 Jul 26.


Activation of transient receptor potential ankyrin-1 (TRPA1) in lung cells by wood smoke particulate material.

Shapiro D, Deering-Rice CE, Romero EG, Hughen RW, Light AR, Veranth JM, Reilly CA.

Chem Res Toxicol. 2013 May 20;26(5):750-8. doi: 10.1021/tx400024h. Epub 2013 Apr 25.


Phytochemistry: ibuprofen-like activity in extra-virgin olive oil.

Beauchamp GK, Keast RS, Morel D, Lin J, Pika J, Han Q, Lee CH, Smith AB, Breslin PA.

Nature. 2005 Sep 1;437(7055):45-6.


Direct measurement of oleocanthal and oleacein levels in olive oil by quantitative (1)H NMR. Establishment of a new index for the characterization of extra virgin olive oils.

Karkoula E, Skantzari A, Melliou E, Magiatis P.

J Agric Food Chem. 2012 Nov 28;60(47):11696-703. doi: 10.1021/jf3032765. Epub 2012 Nov 13.


Pungent products from garlic activate the sensory ion channel TRPA1.

Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Högestätt ED, Julius D, Jordt SE, Zygmunt PM.

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12248-52. Epub 2005 Aug 15.


Oleocanthal, a phenolic derived from virgin olive oil: a review of the beneficial effects on inflammatory disease.

Parkinson L, Keast R.

Int J Mol Sci. 2014 Jul 11;15(7):12323-34. doi: 10.3390/ijms150712323. Review.


Etodolac activates and desensitizes transient receptor potential ankyrin 1.

Wang S, Dai Y, Kogure Y, Yamamoto S, Zhang W, Noguchi K.

J Neurosci Res. 2013 Dec;91(12):1591-8. doi: 10.1002/jnr.23274. Epub 2013 Aug 30.

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