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Items: 1 to 20 of 90

1.

Rheb1 is required for mTORC1 and myelination in postnatal brain development.

Zou J, Zhou L, Du XX, Ji Y, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PY, Worley PF, Xiao B.

Dev Cell. 2011 Jan 18;20(1):97-108. doi: 10.1016/j.devcel.2010.11.020.

2.

Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain.

Zou Y, Jiang W, Wang J, Li Z, Zhang J, Bu J, Zou J, Zhou L, Yu S, Cui Y, Yang W, Luo L, Lu QR, Liu Y, Chen M, Worley PF, Xiao B.

J Neurosci. 2014 Nov 19;34(47):15764-78. doi: 10.1523/JNEUROSCI.2267-14.2014.

3.

Genetic deletion of Rheb1 in the brain reduces food intake and causes hypoglycemia with altered peripheral metabolism.

Yang W, Jiang W, Luo L, Bu J, Pang D, Wei J, Du C, Xia X, Cui Y, Liu S, Mao Q, Chen M.

Int J Mol Sci. 2014 Jan 21;15(1):1499-510. doi: 10.3390/ijms15011499.

4.

Genetic and pharmacological inhibition of Rheb1-mTORC1 signaling exerts cardioprotection against adverse cardiac remodeling in mice.

Wu X, Cao Y, Nie J, Liu H, Lu S, Hu X, Zhu J, Zhao X, Chen J, Chen X, Yang Z, Li X.

Am J Pathol. 2013 Jun;182(6):2005-14. doi: 10.1016/j.ajpath.2013.02.012. Epub 2013 Apr 6.

PMID:
23567640
5.

PIKE is essential for oligodendroglia development and CNS myelination.

Chan CB, Liu X, Zhao L, Liu G, Lee CW, Feng Y, Ye K.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1993-8. doi: 10.1073/pnas.1318185111. Epub 2014 Jan 21.

6.

Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.

Sato T, Nakashima A, Guo L, Tamanoi F.

J Biol Chem. 2009 May 8;284(19):12783-91. doi: 10.1074/jbc.M809207200. Epub 2009 Mar 19.

7.

Cardiac ablation of Rheb1 induces impaired heart growth, endoplasmic reticulum-associated apoptosis and heart failure in infant mice.

Cao Y, Tao L, Shen S, Xiao J, Wu H, Li B, Wu X, Luo W, Xiao Q, Hu X, Liu H, Nie J, Lu S, Yuan B, Han Z, Xiao B, Yang Z, Li X.

Int J Mol Sci. 2013 Dec 13;14(12):24380-98. doi: 10.3390/ijms141224380.

8.

MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation.

Fawal MA, Brandt M, Djouder N.

Dev Cell. 2015 Apr 6;33(1):67-81. doi: 10.1016/j.devcel.2015.02.010. Epub 2015 Mar 26.

9.

Spatial regulation of the mTORC1 system in amino acids sensing pathway.

Suzuki T, Inoki K.

Acta Biochim Biophys Sin (Shanghai). 2011 Sep;43(9):671-9. doi: 10.1093/abbs/gmr066. Epub 2011 Jul 23. Review.

10.

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM.

Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22.

11.

Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.

Saci A, Cantley LC, Carpenter CL.

Mol Cell. 2011 Apr 8;42(1):50-61. doi: 10.1016/j.molcel.2011.03.017.

12.

Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis.

Jiang L, Xu L, Mao J, Li J, Fang L, Zhou Y, Liu W, He W, Zhao AZ, Yang J, Dai C.

J Am Soc Nephrol. 2013 Jun;24(7):1114-26. doi: 10.1681/ASN.2012050476. Epub 2013 May 9.

13.

Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination.

Lebrun-Julien F, Bachmann L, Norrmén C, Trötzmüller M, Köfeler H, Rüegg MA, Hall MN, Suter U.

J Neurosci. 2014 Jun 18;34(25):8432-48. doi: 10.1523/JNEUROSCI.1105-14.2014.

14.

Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway.

Yoshida S, Hong S, Suzuki T, Nada S, Mannan AM, Wang J, Okada M, Guan KL, Inoki K.

J Biol Chem. 2011 Sep 16;286(37):32651-60. doi: 10.1074/jbc.M111.238014. Epub 2011 Jul 22.

15.
16.

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD.

Nat Immunol. 2011 Apr;12(4):295-303. doi: 10.1038/ni.2005. Epub 2011 Feb 27.

17.

Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.

Tamai T, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Oyabu J, Murakawa T, Nakayama H, Uno Y, Horie K, Nishida K, Sonenberg N, Shah AM, Takeda J, Komuro I, Otsu K.

J Biol Chem. 2013 Apr 5;288(14):10176-87. doi: 10.1074/jbc.M112.423640. Epub 2013 Feb 20.

18.

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM.

Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8.

19.

TACE/ADAM17 is essential for oligodendrocyte development and CNS myelination.

Palazuelos J, Crawford HC, Klingener M, Sun B, Karelis J, Raines EW, Aguirre A.

J Neurosci. 2014 Sep 3;34(36):11884-96. doi: 10.1523/JNEUROSCI.1220-14.2014.

20.

Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.

Narayanan SP, Flores AI, Wang F, Macklin WB.

J Neurosci. 2009 May 27;29(21):6860-70. doi: 10.1523/JNEUROSCI.0232-09.2009.

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