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Results: 1 to 20 of 104

1.

TAKEDA-143242 increased survival via reduced cytokines in porcine peritonitis.

Goldfarb RD, Ortegel JW, Parrillo JE, Zanotti-Cavazzoni S, Casey LC, Dellinger RP.

J Surg Res. 2011 Apr;166(2):e165-73. doi: 10.1016/j.jss.2010.09.031. Epub 2010 Nov 11.

PMID:
21236445
[PubMed - indexed for MEDLINE]
2.

Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model.

Sha T, Sunamoto M, Kitazaki T, Sato J, Ii M, Iizawa Y.

Eur J Pharmacol. 2007 Oct 1;571(2-3):231-9. Epub 2007 Jun 29.

PMID:
17632100
[PubMed - indexed for MEDLINE]
3.

A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.

Ii M, Matsunaga N, Hazeki K, Nakamura K, Takashima K, Seya T, Hazeki O, Kitazaki T, Iizawa Y.

Mol Pharmacol. 2006 Apr;69(4):1288-95. Epub 2005 Dec 22.

PMID:
16373689
[PubMed - indexed for MEDLINE]
Free Article
4.

Cytokine production after intravenous or peritoneal gram-negative bacterial challenge in mice. Comparative protective efficacy of antibodies to tumor necrosis factor-alpha and to lipopolysaccharide.

Zanetti G, Heumann D, Gérain J, Kohler J, Abbet P, Barras C, Lucas R, Glauser MP, Baumgartner JD.

J Immunol. 1992 Mar 15;148(6):1890-7.

PMID:
1541827
[PubMed - indexed for MEDLINE]
5.

Early effects of lipopolysaccharide on cytokine release, hemodynamic and renal function in newborn piglets.

John E, Pais P, Furtado N, Chin A, Radhakrishnan J, Fornell L, Lumpaopong A, Beier UH.

Neonatology. 2008;93(2):106-12. Epub 2007 Aug 16.

PMID:
17703105
[PubMed - indexed for MEDLINE]
6.

Anti-interleukin-12 therapy protects mice in lethal endotoxemia but impairs bacterial clearance in murine Escherichia coli peritoneal sepsis.

Zisman DA, Kunkel SL, Strieter RM, Gauldie J, Tsai WC, Bramson J, Wilkowski JM, Bucknell KA, Standiford TJ.

Shock. 1997 Nov;8(5):349-56.

PMID:
9361345
[PubMed - indexed for MEDLINE]
7.

Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis.

Goldfarb RD, Marton A, Szabó E, Virág L, Salzman AL, Glock D, Akhter I, McCarthy R, Parrillo JE, Szabó C.

Crit Care Med. 2002 May;30(5):974-80.

PMID:
12006790
[PubMed - indexed for MEDLINE]
8.

Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscle.

Lang CH, Silvis C, Deshpande N, Nystrom G, Frost RA.

Shock. 2003 Jun;19(6):538-46.

PMID:
12785009
[PubMed - indexed for MEDLINE]
10.

Polyvalent immunoglobulin significantly attenuated the formation of IL-1β in Escherichia coli-induced sepsis in pigs.

Barratt-Due A, Sokolov A, Gustavsen A, Hellerud BC, Egge K, Pischke SE, Lindstad JK, Pharo A, Castellheim A, Thorgersen EB, Mollnes TE.

Immunobiology. 2013 May;218(5):683-9. doi: 10.1016/j.imbio.2012.08.268. Epub 2012 Aug 9.

PMID:
22947599
[PubMed - indexed for MEDLINE]
11.

Effect of antimicrobial agents on the toll-like receptors and inflammatory cytokines in liver tissue of the alcohol-induced liver disease in rats with Vibrio vulnificus sepsis.

Lu ZQ, Li MF, Qiu QM, Liang H, Zhou TL, Hong GL, Wu B.

Chin Med J (Engl). 2009 Aug 20;122(16):1910-6.

PMID:
19781370
[PubMed - indexed for MEDLINE]
Free Article
12.

Change of TH1/TH2 cytokine equilibrium in rats with severe sepsis and therapeutic effect of recombinant interleukin-12 and Shenmai injection.

Yu YH, Cui NQ, Fu Q, Li J.

Chin J Integr Med. 2005 Jun;11(2):136-41.

PMID:
16150202
[PubMed - indexed for MEDLINE]
13.

Randomized, blinded, placebo-controlled trial of tissue factor pathway inhibitor in porcine septic shock.

Goldfarb RD, Glock D, Johnson K, Creasey AA, Carr C, McCarthy RJ, Matushek M, Akhter I, Trenholme G, Parrillo JE.

Shock. 1998 Oct;10(4):258-64.

PMID:
9788657
[PubMed - indexed for MEDLINE]
14.

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain.

Kawamoto T, Ii M, Kitazaki T, Iizawa Y, Kimura H.

Eur J Pharmacol. 2008 Apr 14;584(1):40-8. doi: 10.1016/j.ejphar.2008.01.026. Epub 2008 Feb 5.

PMID:
18299127
[PubMed - indexed for MEDLINE]
15.

Targeting macrophages with microspheres containing cytokine-neutralizing antibodies prevents lethality in gram-negative peritonitis.

Oettinger CW, D'Souza M, Milton GV.

J Interferon Cytokine Res. 1999 Jan;19(1):33-40.

PMID:
10048766
[PubMed - indexed for MEDLINE]
16.

The novel selective toll-like receptor 4 signal transduction inhibitor tak-242 prevents endotoxaemia in conscious Guinea-pigs.

Kuno M, Nemoto K, Ninomiya N, Inagaki E, Kubota M, Matsumoto T, Yokota H.

Clin Exp Pharmacol Physiol. 2009 May;36(5-6):589-93. doi: 10.1111/j.1440-1681.2008.05121.x. Epub 2008 Oct 27.

PMID:
19673945
[PubMed - indexed for MEDLINE]
17.

Isoflurane improves survival and protects against renal and hepatic injury in murine septic peritonitis.

Lee HT, Emala CW, Joo JD, Kim M.

Shock. 2007 Apr;27(4):373-9.

PMID:
17414419
[PubMed - indexed for MEDLINE]
18.

Elevation of tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 levels in aortic intima of Chinese Guizhou minipigs with streptozotocin-induced diabetes.

Lu L, Zhang Q, Pu LJ, Xu XW, Zhang RY, Zhang JS, Hu J, Yang ZK, Lü AK, Ding FH, Shen J, Chen QJ, Lou S, Fang DH, Shen WF.

Chin Med J (Engl). 2007 Mar 20;120(6):479-84.

PMID:
17439741
[PubMed - indexed for MEDLINE]
Free Article
19.

Differential sensitivity to Escherichia coli infection in mice lacking tumor necrosis factor p55 or interleukin-1 p80 receptors.

Acton RD, Dahlberg PS, Uknis ME, Klaerner HG, Fink GS, Norman JG, Dunn DL.

Arch Surg. 1996 Nov;131(11):1216-21.

PMID:
8911263
[PubMed - indexed for MEDLINE]
20.

Failure of prophylactic and therapeutic use of a murine anti-tumor necrosis factor monoclonal antibody in Escherichia coli sepsis in the rabbit.

Stack AM, Saladino RA, Thompson C, Sattler F, Weiner DL, Parsonnet J, Nariuchi H, Siber GR, Fleisher GR.

Crit Care Med. 1995 Sep;23(9):1512-8.

PMID:
7664553
[PubMed - indexed for MEDLINE]

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