Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 111

1.

Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy.

Li LS, Bey EA, Dong Y, Meng J, Patra B, Yan J, Xie XJ, Brekken RA, Barnett CC, Bornmann WG, Gao J, Boothman DA.

Clin Cancer Res. 2011 Jan 15;17(2):275-85. doi: 10.1158/1078-0432.CCR-10-1983. Epub 2011 Jan 11. Erratum in: Clin Cancer Res. 2011 Mar 1;17(5):1210-1.

PMID:
21224367
[PubMed - indexed for MEDLINE]
Free Article
2.

An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis.

Huang X, Dong Y, Bey EA, Kilgore JA, Bair JS, Li LS, Patel M, Parkinson EI, Wang Y, Williams NS, Gao J, Hergenrother PJ, Boothman DA.

Cancer Res. 2012 Jun 15;72(12):3038-47. doi: 10.1158/0008-5472.CAN-11-3135. Epub 2012 Apr 24.

PMID:
22532167
[PubMed - indexed for MEDLINE]
Free Article
3.

Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers.

Bey EA, Reinicke KE, Srougi MC, Varnes M, Anderson VE, Pink JJ, Li LS, Patel M, Cao L, Moore Z, Rommel A, Boatman M, Lewis C, Euhus DM, Bornmann WG, Buchsbaum DJ, Spitz DR, Gao J, Boothman DA.

Mol Cancer Ther. 2013 Oct;12(10):2110-20. doi: 10.1158/1535-7163.MCT-12-0962. Epub 2013 Jul 24.

PMID:
23883585
[PubMed - indexed for MEDLINE]
4.

An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.

Bey EA, Bentle MS, Reinicke KE, Dong Y, Yang CR, Girard L, Minna JD, Bornmann WG, Gao J, Boothman DA.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11832-7. Epub 2007 Jul 3.

PMID:
17609380
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.

Bentle MS, Reinicke KE, Dong Y, Bey EA, Boothman DA.

Cancer Res. 2007 Jul 15;67(14):6936-45.

PMID:
17638905
[PubMed - indexed for MEDLINE]
Free Article
6.

Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation.

Dong Y, Bey EA, Li LS, Kabbani W, Yan J, Xie XJ, Hsieh JT, Gao J, Boothman DA.

Cancer Res. 2010 Oct 15;70(20):8088-96. doi: 10.1158/0008-5472.CAN-10-1418. Epub 2010 Oct 12.

PMID:
20940411
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Heat-induced up-regulation of NAD(P)H:quinone oxidoreductase potentiates anticancer effects of beta-lapachone.

Park HJ, Choi EK, Choi J, Ahn KJ, Kim EJ, Ji IM, Kook YH, Ahn SD, Williams B, Griffin R, Boothman DA, Lee CK, Song CW.

Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8866-71.

PMID:
16361576
[PubMed - indexed for MEDLINE]
Free Article
8.

Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels.

Reinicke KE, Bey EA, Bentle MS, Pink JJ, Ingalls ST, Hoppel CL, Misico RI, Arzac GM, Burton G, Bornmann WG, Sutton D, Gao J, Boothman DA.

Clin Cancer Res. 2005 Apr 15;11(8):3055-64.

PMID:
15837761
[PubMed - indexed for MEDLINE]
Free Article
9.

Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock.

Song CW, Chae JJ, Choi EK, Hwang TS, Kim C, Lim BU, Park HJ.

Int J Hyperthermia. 2008 Mar;24(2):161-9. doi: 10.1080/02656730701781895.

PMID:
18283592
[PubMed - indexed for MEDLINE]
10.

Susceptibility of cancer cells to beta-lapachone is enhanced by ionizing radiation.

Park HJ, Ahn KJ, Ahn SD, Choi E, Lee SW, Williams B, Kim EJ, Griffin R, Bey EA, Bornmann WG, Gao J, Park HJ, Boothman DA, Song CW.

Int J Radiat Oncol Biol Phys. 2005 Jan 1;61(1):212-9.

PMID:
15629614
[PubMed - indexed for MEDLINE]
11.

beta-Lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3.

Planchon SM, Pink JJ, Tagliarino C, Bornmann WG, Varnes ME, Boothman DA.

Exp Cell Res. 2001 Jul 1;267(1):95-106.

PMID:
11412042
[PubMed - indexed for MEDLINE]
12.

Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.

Choi EK, Terai K, Ji IM, Kook YH, Park KH, Oh ET, Griffin RJ, Lim BU, Kim JS, Lee DS, Boothman DA, Loren M, Song CW, Park HJ.

Neoplasia. 2007 Aug;9(8):634-42.

PMID:
17786182
[PubMed - indexed for MEDLINE]
Free PMC Article
13.
14.

Cisplatin enhances the anticancer effect of beta-lapachone by upregulating NQO1.

Terai K, Dong GZ, Oh ET, Park MT, Gu Y, Song CW, Park HJ.

Anticancer Drugs. 2009 Nov;20(10):901-9. doi: 10.1097/CAD.0b013e328330098d.

PMID:
19738461
[PubMed - indexed for MEDLINE]
15.

Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells.

Blanco E, Bey EA, Dong Y, Weinberg BD, Sutton DM, Boothman DA, Gao J.

J Control Release. 2007 Oct 8;122(3):365-74. Epub 2007 Apr 29.

PMID:
17574288
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

β-lapachone significantly increases the effect of ionizing radiation to cause mitochondrial apoptosis via JNK activation in cancer cells.

Park MT, Song MJ, Lee H, Oh ET, Choi BH, Jeong SY, Choi EK, Park HJ.

PLoS One. 2011;6(10):e25976. doi: 10.1371/journal.pone.0025976. Epub 2011 Oct 6.

PMID:
21998736
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Synergistic enhancement of antitumor effect of β-Lapachone by photodynamic induction of quinone oxidoreductase (NQO1).

Lamberti MJ, Vittar NB, da Silva Fde C, Ferreira VF, Rivarola VA.

Phytomedicine. 2013 Aug 15;20(11):1007-12. doi: 10.1016/j.phymed.2013.04.018. Epub 2013 Jun 7.

PMID:
23746950
[PubMed - indexed for MEDLINE]
18.

Intratumoral delivery of beta-lapachone via polymer implants for prostate cancer therapy.

Dong Y, Chin SF, Blanco E, Bey EA, Kabbani W, Xie XJ, Bornmann WG, Boothman DA, Gao J.

Clin Cancer Res. 2009 Jan 1;15(1):131-9. doi: 10.1158/1078-0432.CCR-08-1691.

PMID:
19118040
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1.

Ough M, Lewis A, Bey EA, Gao J, Ritchie JM, Bornmann W, Boothman DA, Oberley LW, Cullen JJ.

Cancer Biol Ther. 2005 Jan;4(1):95-102. Epub 2005 Jan 15.

PMID:
15662131
[PubMed - indexed for MEDLINE]
Free Article
20.

Heat shock increases expression of NAD(P)H:quinone oxidoreductase (NQO1), mediator of beta-lapachone cytotoxicity, by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein.

Dong GZ, Youn H, Park MT, Oh ET, Park KH, Song CW, Choi EK, Park HJ.

Int J Hyperthermia. 2009;25(6):477-87. doi: 10.1080/02656730903049836.

PMID:
19657853
[PubMed - indexed for MEDLINE]

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk