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Results: 1 to 20 of 108

1.

In vitro hybridization and separation of hybrids of human adenylosuccinate lyase from wild-type and disease-associated mutant enzymes.

De Zoysa Ariyananda L, Antonopoulos C, Currier J, Colman RF.

Biochemistry. 2011 Mar 1;50(8):1336-46. doi: 10.1021/bi101734q. Epub 2011 Feb 3.

PMID:
21210713
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Biochemical and biophysical analysis of five disease-associated human adenylosuccinate lyase mutants.

Ariyananda Lde Z, Lee P, Antonopoulos C, Colman RF.

Biochemistry. 2009 Jun 16;48(23):5291-302. doi: 10.1021/bi802321m.

PMID:
19405474
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Three subunits contribute amino acids to the active site of tetrameric adenylosuccinate lyase: Lys268 and Glu275 are required.

Brosius JL, Colman RF.

Biochemistry. 2002 Feb 19;41(7):2217-26.

PMID:
11841213
[PubMed - indexed for MEDLINE]
5.

Two novel mutant human adenylosuccinate lyases (ASLs) associated with autism and characterization of the equivalent mutant Bacillus subtilis ASL.

Sivendran S, Patterson D, Spiegel E, McGown I, Cowley D, Colman RF.

J Biol Chem. 2004 Dec 17;279(51):53789-97. Epub 2004 Oct 7.

PMID:
15471876
[PubMed - indexed for MEDLINE]
Free Article
6.

Elucidation of the substrate specificity, kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum.

Bulusu V, Srinivasan B, Bopanna MP, Balaram H.

Biochim Biophys Acta. 2009 Apr;1794(4):642-54. doi: 10.1016/j.bbapap.2008.11.021. Epub 2008 Dec 7.

PMID:
19111634
[PubMed - indexed for MEDLINE]
Free Article
7.

Evaluation of types of interactions in subunit association in Bacillus subtilis adenylosuccinate lyase.

De Zoysa Ariyananda L, Colman RF.

Biochemistry. 2008 Mar 4;47(9):2923-34. doi: 10.1021/bi701400c. Epub 2008 Feb 1.

PMID:
18237141
[PubMed - indexed for MEDLINE]
8.

The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase deficiencies.

Palenchar JB, Crocco JM, Colman RF.

Protein Sci. 2003 Aug;12(8):1694-705.

PMID:
12876319
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Expression, purification, and kinetic characterization of recombinant human adenylosuccinate lyase.

Stone RL, Zalkin H, Dixon JE.

J Biol Chem. 1993 Sep 15;268(26):19710-6.

PMID:
8366112
[PubMed - indexed for MEDLINE]
Free Article
10.

Effect of Asp69 and Arg310 on the pK of His68, a key catalytic residue of adenylosuccinate lyase.

Sivendran S, Segall ML, Rancy PC, Colman RF.

Protein Sci. 2007 Aug;16(8):1700-7. Epub 2007 Jun 28.

PMID:
17600142
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Adenylosuccinate lyase deficiency: from the clinics to molecular biology.

Marie S, Race V, Vincent MF, Van den Berghe G.

Adv Exp Med Biol. 2000;486:79-82. No abstract available.

PMID:
11783532
[PubMed - indexed for MEDLINE]
12.

Gln212, Asn270, and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis.

Segall ML, Colman RF.

Biochemistry. 2004 Jun 15;43(23):7391-402.

PMID:
15182182
[PubMed - indexed for MEDLINE]
13.

His68 and His141 are critical contributors to the intersubunit catalytic site of adenylosuccinate lyase of Bacillus subtilis.

Lee TT, Worby C, Bao ZQ, Dixon JE, Colman RF.

Biochemistry. 1999 Jan 5;38(1):22-32.

PMID:
9890879
[PubMed - indexed for MEDLINE]
14.

Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency.

Race V, Marie S, Vincent MF, Van den Berghe G.

Hum Mol Genet. 2000 Sep 1;9(14):2159-65.

PMID:
10958654
[PubMed - indexed for MEDLINE]
Free Article
15.

Structural and biochemical characterization of human adenylosuccinate lyase (ADSL) and the R303C ADSL deficiency-associated mutation.

Ray SP, Deaton MK, Capodagli GC, Calkins LA, Sawle L, Ghosh K, Patterson D, Pegan SD.

Biochemistry. 2012 Aug 21;51(33):6701-13. doi: 10.1021/bi300796y. Epub 2012 Aug 7.

PMID:
22812634
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Effect of a new non-cleavable substrate analog on wild-type and serine mutants in the signature sequence of adenylosuccinate lyase of Bacillus subtilis and Homo sapiens.

Sivendran S, Colman RF.

Protein Sci. 2008 Jul;17(7):1162-74. doi: 10.1110/ps.034777.108. Epub 2008 May 9.

PMID:
18469177
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

A key role in catalysis for His89 of adenylosuccinate lyase of Bacillus subtilis.

Brosius JL, Colman RF.

Biochemistry. 2000 Nov 7;39(44):13336-43.

PMID:
11063569
[PubMed - indexed for MEDLINE]
18.

Important roles of hydroxylic amino acid residues in the function of Bacillus subtilis adenylosuccinate lyase.

Segall ML, Cashman MA, Colman RF.

Protein Sci. 2007 Mar;16(3):441-8.

PMID:
17322529
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Inherent properties of adenylosuccinate lyase could explain S-Ado/SAICAr ratio due to homozygous R426H and R303C mutations.

Ray SP, Duval N, Wilkinson TG 2nd, Shaheen SE, Ghosh K, Patterson D.

Biochim Biophys Acta. 2013 Aug;1834(8):1545-53. doi: 10.1016/j.bbapap.2013.05.013. Epub 2013 May 25.

PMID:
23714113
[PubMed - indexed for MEDLINE]
Free Article
20.

Expression, purification, and characterization of stable, recombinant human adenylosuccinate lyase.

Lee P, Colman RF.

Protein Expr Purif. 2007 Feb;51(2):227-34. Epub 2006 Aug 9.

PMID:
16973378
[PubMed - indexed for MEDLINE]

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