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Results: 1 to 20 of 101

1.

In vivo imaging of HIF-active tumors by an oxygen-dependent degradation protein probe with an interchangeable labeling system.

Kuchimaru T, Kadonosono T, Tanaka S, Ushiki T, Hiraoka M, Kizaka-Kondoh S.

PLoS One. 2010 Dec 23;5(12):e15736. doi: 10.1371/journal.pone.0015736.

PMID:
21203417
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion protein probe.

Fujita Y, Kuchimaru T, Kadonosono T, Tanaka S, Hase Y, Tomimoto H, Hiraoka M, Kizaka-Kondoh S, Ihara M, Takahashi R.

PLoS One. 2012;7(10):e48051. doi: 10.1371/journal.pone.0048051. Epub 2012 Oct 19.

PMID:
23094105
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Imaging of HIF-1-active tumor hypoxia using a protein effectively delivered to and specifically stabilized in HIF-1-active tumor cells.

Kudo T, Ueda M, Kuge Y, Mukai T, Tanaka S, Masutani M, Kiyono Y, Kizaka-Kondoh S, Hiraoka M, Saji H.

J Nucl Med. 2009 Jun;50(6):942-9. doi: 10.2967/jnumed.108.061119. Epub 2009 May 14.

PMID:
19443598
[PubMed - indexed for MEDLINE]
Free Article
5.

Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation.

D'Angelo G, Duplan E, Boyer N, Vigne P, Frelin C.

J Biol Chem. 2003 Oct 3;278(40):38183-7. Epub 2003 Jul 21.

PMID:
12876291
[PubMed - indexed for MEDLINE]
Free Article
6.

The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts.

Harada H, Kizaka-Kondoh S, Itasaka S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M.

Biochem Biophys Res Commun. 2007 Sep 7;360(4):791-6. Epub 2007 Jul 5.

PMID:
17624305
[PubMed - indexed for MEDLINE]
7.

A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery.

Alcaide-German ML, Vara-Vega A, Garcia-Fernandez LF, Landazuri MO, del Peso L.

BMC Cell Biol. 2008 Apr 10;9:18. doi: 10.1186/1471-2121-9-18.

PMID:
18402654
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells.

Harada H, Hiraoka M, Kizaka-Kondoh S.

Cancer Res. 2002 Apr 1;62(7):2013-8.

PMID:
11929818
[PubMed - indexed for MEDLINE]
Free Article
9.

Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model.

Schmierer B, Novák B, Schofield CJ.

BMC Syst Biol. 2010 Oct 18;4:139. doi: 10.1186/1752-0509-4-139.

PMID:
20955552
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer.

Kizaka-Kondoh S, Itasaka S, Zeng L, Tanaka S, Zhao T, Takahashi Y, Shibuya K, Hirota K, Semenza GL, Hiraoka M.

Clin Cancer Res. 2009 May 15;15(10):3433-41. doi: 10.1158/1078-0432.CCR-08-2267. Epub 2009 May 5.

PMID:
19417024
[PubMed - indexed for MEDLINE]
Free Article
11.

Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.

Martin F, Linden T, Katschinski DM, Oehme F, Flamme I, Mukhopadhyay CK, Eckhardt K, Tröger J, Barth S, Camenisch G, Wenger RH.

Blood. 2005 Jun 15;105(12):4613-9. Epub 2005 Mar 1.

PMID:
15741220
[PubMed - indexed for MEDLINE]
Free Article
12.

The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9.

Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, Metzen E.

PLoS One. 2011 Apr 29;6(4):e19151. doi: 10.1371/journal.pone.0019151.

PMID:
21559462
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Differential responses of two degradation domains of HIF-1alpha to hypoxia and iron deficiency.

Lee KH, Choi E, Chun YS, Kim MS, Park JW.

Biochimie. 2006 Feb;88(2):163-9. Epub 2005 Aug 19.

PMID:
16139409
[PubMed - indexed for MEDLINE]
14.

Structural and functional analysis of amphioxus HIFα reveals ancient features of the HIFα family.

Gao S, Lu L, Bai Y, Zhang P, Song W, Duan C.

FASEB J. 2014 Apr;28(4):1880-90. doi: 10.1096/fj.12-220152. Epub 2013 Oct 30.

PMID:
24174425
[PubMed - indexed for MEDLINE]
15.

Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.

Berchner-Pfannschmidt U, Yamac H, Trinidad B, Fandrey J.

J Biol Chem. 2007 Jan 19;282(3):1788-96. Epub 2006 Oct 23.

PMID:
17060326
[PubMed - indexed for MEDLINE]
Free Article
16.

Human hormone-refractory prostate cancers can harbor mutations in the O(2)-dependent degradation domain of hypoxia inducible factor-1alpha (HIF-1alpha).

Anastasiadis AG, Ghafar MA, Salomon L, Vacherot F, Benedit P, Chen MW, Shabsigh A, Burchardt M, Chopin DK, Shabsigh R, Buttyan R.

J Cancer Res Clin Oncol. 2002 Jul;128(7):358-62. Epub 2002 May 16.

PMID:
12136249
[PubMed - indexed for MEDLINE]
17.

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.

Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM.

J Biol Chem. 2004 Sep 10;279(37):38458-65. Epub 2004 Jul 7.

PMID:
15247232
[PubMed - indexed for MEDLINE]
Free Article
18.

Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins.

Srinivas V, Zhang LP, Zhu XH, Caro J.

Biochem Biophys Res Commun. 1999 Jul 5;260(2):557-61.

PMID:
10403805
[PubMed - indexed for MEDLINE]
19.

PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis.

Ginouvès A, Ilc K, Macías N, Pouysségur J, Berra E.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4745-50. doi: 10.1073/pnas.0705680105. Epub 2008 Mar 17.

PMID:
18347341
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Mutation analysis of the HIF-1alpha oxygen-dependent degradation domain in invasive breast cancer.

Vleugel MM, Greijer AE, van der Wall E, van Diest PJ.

Cancer Genet Cytogenet. 2005 Dec;163(2):168-72.

PMID:
16337862
[PubMed - indexed for MEDLINE]

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