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N-Glycans mutations rule oligomeric assembly and functional expression of P2X3 receptor for extracellular ATP.

Vacca F, D'Ambrosi N, Nestola V, Amadio S, Giustizieri M, Cucchiaroni ML, Tozzi A, Velluz MC, Mercuri NB, Volonté C.

Glycobiology. 2011 May;21(5):634-43. doi: 10.1093/glycob/cwq211. Epub 2010 Dec 24.


Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells.

Mochizuki K, Kagawa T, Numari A, Harris MJ, Itoh J, Watanabe N, Mine T, Arias IM.

Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G818-28. Epub 2006 Nov 2.


Roles of individual N-glycans for ATP potency and expression of the rat P2X1 receptor.

Rettinger J, Aschrafi A, Schmalzing G.

J Biol Chem. 2000 Oct 27;275(43):33542-7.


Structural and functional analysis of the canine histamine H2 receptor by site-directed mutagenesis: N-glycosylation is not vital for its action.

Fukushima Y, Oka Y, Saitoh T, Katagiri H, Asano T, Matsuhashi N, Takata K, van Breda E, Yazaki Y, Sugano K.

Biochem J. 1995 Sep 1;310 ( Pt 2):553-8.


Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function.

Pabon A, Chan KW, Sui JL, Wu X, Logothetis DE, Thornhill WB.

J Biol Chem. 2000 Sep 29;275(39):30677-82.


Mutations of the asparagine117 residue of a receptor activity-modifying protein 1-dependent human calcitonin gene-related peptide receptor result in selective loss of function.

Gujer R, Aldecoa A, Bühlmann N, Leuthäuser K, Muff R, Fischer JA, Born W.

Biochemistry. 2001 May 8;40(18):5392-8.


Identification of the N-linked glycosylation sites of the human relaxin receptor and effect of glycosylation on receptor function.

Yan Y, Scott DJ, Wilkinson TN, Ji J, Tregear GW, Bathgate RA.

Biochemistry. 2008 Jul 1;47(26):6953-68. doi: 10.1021/bi800535b. Epub 2008 Jun 6.


Glycosylation of the calcitonin receptor-like receptor at Asn(60) or Asn(112) is important for cell surface expression.

Bühlmann N, Aldecoa A, Leuthäuser K, Gujer R, Muff R, Fischer JA, Born W.

FEBS Lett. 2000 Dec 15;486(3):320-4.


Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2.

Nakagawa H, Wakabayashi-Nakao K, Tamura A, Toyoda Y, Koshiba S, Ishikawa T.

FEBS J. 2009 Dec;276(24):7237-52. doi: 10.1111/j.1742-4658.2009.07423.x. Epub .


Characterization of N-glycosylation consensus sequences in the Kv3.1 channel.

Brooks NL, Corey MJ, Schwalbe RA.

FEBS J. 2006 Jul;273(14):3287-300. Epub 2006 Jun 19.


Regulation of the pH sensitivity of human P2X receptors by N-linked glycosylation.

Wirkner K, Stanchev D, Milius D, Hartmann L, Kato E, Zadori ZS, Mager PP, Rubini P, Nörenberg W, Illes P.

J Neurochem. 2008 Dec;107(5):1216-24. doi: 10.1111/j.1471-4159.2008.05655.x. Epub 2008 Sep 6.


Amino acid residues constituting the agonist binding site of the human P2X3 receptor.

Bodnar M, Wang H, Riedel T, Hintze S, Kato E, Fallah G, Gröger-Arndt H, Giniatullin R, Grohmann M, Hausmann R, Schmalzing G, Illes P, Rubini P.

J Biol Chem. 2011 Jan 28;286(4):2739-49. doi: 10.1074/jbc.M110.167437. Epub 2010 Nov 22.


Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.

Kowalski M, Hausmann R, Dopychai A, Grohmann M, Franke H, Nieber K, Schmalzing G, Illes P, Riedel T.

Br J Pharmacol. 2014 Nov;171(22):5093-112. doi: 10.1111/bph.12830. Epub 2014 Sep 5.


Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor.

Jindrichova M, Khafizov K, Skorinkin A, Fayuk D, Bart G, Zemkova H, Giniatullin R.

J Neurochem. 2011 Nov;119(4):676-85. doi: 10.1111/j.1471-4159.2011.07463.x. Epub 2011 Oct 10.


Role of the ectodomain serine 275 in shaping the binding pocket of the ATP-gated P2X3 receptor.

Petrenko N, Khafizov K, Tvrdonova V, Skorinkin A, Giniatullin R.

Biochemistry. 2011 Oct 4;50(39):8427-36. doi: 10.1021/bi200812u. Epub 2011 Sep 9.

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