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Results: 1 to 20 of 109

1.

Structure--activity relationship studies of 1-(4-chloro-2,5-dimethoxyphenyl)-3-(3-propoxypropyl)thiourea, a non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type-1.

Weitman M, Lerman K, Nudelman A, Major DT, Hizi A, Herschhorn A.

Eur J Med Chem. 2011 Feb;46(2):447-67. doi: 10.1016/j.ejmech.2010.11.003. Epub 2010 Nov 10.

PMID:
21159409
[PubMed - indexed for MEDLINE]
2.

Structure-based design of non-nucleoside reverse transcriptase inhibitors of drug-resistant human immunodeficiency virus.

Mao C, Sudbeck EA, Venkatachalam TK, Uckun FM.

Antivir Chem Chemother. 1999 Sep;10(5):233-40.

PMID:
10574178
[PubMed - indexed for MEDLINE]
3.
4.

Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.

Campiani G, Aiello F, Fabbrini M, Morelli E, Ramunno A, Armaroli S, Nacci V, Garofalo A, Greco G, Novellino E, Maga G, Spadari S, Bergamini A, Ventura L, Bongiovanni B, Capozzi M, Bolacchi F, Marini S, Coletta M, Guiso G, Caccia S.

J Med Chem. 2001 Feb 1;44(3):305-15.

PMID:
11462972
[PubMed - indexed for MEDLINE]
5.
6.

Thiourea-based non-nucleoside inhibitors of HIV reverse transcriptase as bifunctional organocatalysts in the asymmetric Strecker synthesis.

Tsogoeva SB, Hateley MJ, Yalalov DA, Meindl K, Weckbecker C, Huthmacher K.

Bioorg Med Chem. 2005 Oct 1;13(19):5680-5.

PMID:
15964195
[PubMed - indexed for MEDLINE]
7.

N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency virus-1.

Uckun FM, Mao C, Pendergrass S, Maher D, Zhu D, Tuel-Ahlgren L, Venkatachalam TK.

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2721-6.

PMID:
10509923
[PubMed - indexed for MEDLINE]
8.

Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 2).

Lavecchia A, Costi R, Artico M, Miele G, Novellino E, Bergamini A, Crespan E, Maga G, Di Santo R.

ChemMedChem. 2006 Dec;1(12):1379-90.

PMID:
17089434
[PubMed - indexed for MEDLINE]
9.

Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase.

Venkatachalam TK, Sudbeck EA, Mao C, Uckun FM.

Bioorg Med Chem Lett. 2000 Sep 18;10(18):2071-4.

PMID:
10999473
[PubMed - indexed for MEDLINE]
10.

Novel broad-spectrum thiourea non-nucleoside inhibitors for the prevention of mucosal HIV transmission.

D'Cruz OJ, Uckun FM.

Curr HIV Res. 2006 Jul;4(3):329-45. Review.

PMID:
16842085
[PubMed - indexed for MEDLINE]
11.

Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents.

Campiani G, Fabbrini M, Morelli E, Nacci V, Greco G, Novellino E, Maga G, Spadari S, Bergamini A, Faggioli E, Uccella I, Bolacchi F, Marini S, Coletta M, Fracasso C, Caccia S.

Antivir Chem Chemother. 2000 Mar;11(2):141-55.

PMID:
10819438
[PubMed - indexed for MEDLINE]
12.

Effect of stereochemistry on the anti-HIV activity of chiral thiourea compounds.

Venkatachalam TK, Mao C, Uckun FM.

Bioorg Med Chem. 2004 Aug 1;12(15):4275-84.

PMID:
15246104
[PubMed - indexed for MEDLINE]
13.

The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors.

Xu G, Micklatcher M, Silvestri MA, Hartman TL, Burrier J, Osterling MC, Wargo H, Turpin JA, Buckheit RW Jr, Cushman M.

J Med Chem. 2001 Nov 22;44(24):4092-113.

PMID:
11708913
[PubMed - indexed for MEDLINE]
14.

Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Mai A, Sbardella G, Artico M, Ragno R, Massa S, Novellino E, Greco G, Lavecchia A, Musiu C, La Colla M, Murgioni C, La Colla P, Loddo R.

J Med Chem. 2001 Aug 2;44(16):2544-54.

PMID:
11472208
[PubMed - indexed for MEDLINE]
15.

Potent dual anti-HIV and spermicidal activities of novel oxovanadium(V) complexes with thiourea non-nucleoside inhibitors of HIV-1 reverse transcriptase.

D'Cruz OJ, Dong Y, Uckun FM.

Biochem Biophys Res Commun. 2003 Mar 7;302(2):253-64.

PMID:
12604339
[PubMed - indexed for MEDLINE]
16.

Virtual screening, identification, and biochemical characterization of novel inhibitors of the reverse transcriptase of human immunodeficiency virus type-1.

Herschhorn A, Hizi A.

J Med Chem. 2008 Sep 25;51(18):5702-13. doi: 10.1021/jm800473d.

PMID:
18800765
[PubMed - indexed for MEDLINE]
17.

Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles.

Roth T, Morningstar ML, Boyer PL, Hughes SH, Buckheit RW Jr, Michejda CJ.

J Med Chem. 1997 Dec 19;40(26):4199-207.

PMID:
9435891
[PubMed - indexed for MEDLINE]
18.

Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors.

Arranz ME, Díaz JA, Ingate ST, Witvrouw M, Pannecouque C, Balzarini J, De Clercq E, Vega S.

Bioorg Med Chem. 1999 Dec;7(12):2811-22.

PMID:
10658585
[PubMed - indexed for MEDLINE]
19.

N-[2-(4-methylphenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea as a potent inhibitor of NNRTI-resistant and multidrug-resistant human immunodeficiency virus type 1.

Uckun FM, Mao C, Pendergrass S, Maher D, Zhu D, Tuel-Ahlgren L, Venkatachalam TK.

Antivir Chem Chemother. 2000 Mar;11(2):135-40.

PMID:
10819437
[PubMed - indexed for MEDLINE]
20.

C-2-aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors.

Hunter R, Younis Y, Muhanji CI, Curtin TL, Naidoo KJ, Petersen M, Bailey CM, Basavapathruni A, Anderson KS.

Bioorg Med Chem. 2008 Dec 15;16(24):10270-80. doi: 10.1016/j.bmc.2008.10.048. Epub 2008 Nov 1.

PMID:
18996020
[PubMed - indexed for MEDLINE]
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