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Results: 1 to 20 of 143

Similar articles for PubMed (Select 21158688)

1.

Profiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-à-go-go related gene potassium channels.

Zou B, Yu H, Babcock JJ, Chanda P, Bader JS, McManus OB, Li M.

Assay Drug Dev Technol. 2010 Dec;8(6):743-54. doi: 10.1089/adt.2010.0339.

2.

A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel.

Schmalhofer WA, Swensen AM, Thomas BS, Felix JP, Haedo RJ, Solly K, Kiss L, Kaczorowski GJ, Garcia ML.

Assay Drug Dev Technol. 2010 Dec;8(6):714-26. doi: 10.1089/adt.2010.0351.

PMID:
21158686
3.

Comparison of human Ether-à-go-go related gene screening assays based on IonWorks Quattro and thallium flux.

Bridal TR, Margulis M, Wang X, Donio M, Sorota S.

Assay Drug Dev Technol. 2010 Dec;8(6):755-65. doi: 10.1089/adt.2010.0267. Epub 2010 Jul 26.

PMID:
20658944
4.

A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.

Titus SA, Beacham D, Shahane SA, Southall N, Xia M, Huang R, Hooten E, Zhao Y, Shou L, Austin CP, Zheng W.

Anal Biochem. 2009 Nov 1;394(1):30-8. doi: 10.1016/j.ab.2009.07.003. Epub 2009 Jul 5.

5.

Development of a high-throughput electrophysiological assay for the human ether-à-go-go related potassium channel hERG.

Gillie DJ, Novick SJ, Donovan BT, Payne LA, Townsend C.

J Pharmacol Toxicol Methods. 2013 Jan-Feb;67(1):33-44. doi: 10.1016/j.vascn.2012.10.002. Epub 2012 Oct 26.

PMID:
23103595
6.

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

Huang XP, Mangano T, Hufeisen S, Setola V, Roth BL.

Assay Drug Dev Technol. 2010 Dec;8(6):727-42. doi: 10.1089/adt.2010.0331.

7.

Characterization of a hERG screen using the IonWorks HT: comparison to a hERG rubidium efflux screen.

Sorota S, Zhang XS, Margulis M, Tucker K, Priestley T.

Assay Drug Dev Technol. 2005 Feb;3(1):47-57.

PMID:
15798395
8.

IonFlux: a microfluidic patch clamp system evaluated with human Ether-à-go-go related gene channel physiology and pharmacology.

Golden AP, Li N, Chen Q, Lee T, Nevill T, Cao X, Johnson J, Erdemli G, Ionescu-Zanetti C, Urban L, Holmqvist M.

Assay Drug Dev Technol. 2011 Dec;9(6):608-19. doi: 10.1089/adt.2010.0362. Epub 2011 May 11.

PMID:
21561375
9.

Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks HT.

Bridgland-Taylor MH, Hargreaves AC, Easter A, Orme A, Henthorn DC, Ding M, Davis AM, Small BG, Heapy CG, Abi-Gerges N, Persson F, Jacobson I, Sullivan M, Albertson N, Hammond TG, Sullivan E, Valentin JP, Pollard CE.

J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):189-99. Epub 2006 Mar 6.

PMID:
16563806
10.

High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment.

Di Veroli GY, Davies MR, Zhang H, Abi-Gerges N, Boyett MR.

Am J Physiol Heart Circ Physiol. 2013 Jan 1;304(1):H104-17. doi: 10.1152/ajpheart.00511.2012. Epub 2012 Oct 26.

11.

Halide ion effects on human Ether-à-go-go related gene potassium channel properties.

Zeng H, Balasubramanian B, Penniman JR, Kinose F, Salata JJ, Lagrutta A.

Assay Drug Dev Technol. 2013 Nov-Dec;11(9-10):544-50. doi: 10.1089/adt.2013.531. Epub 2013 Oct 22.

PMID:
24147984
12.

Improved throughput of PatchXpress hERG assay using intracellular potassium fluoride.

Zeng H, Penniman JR, Kinose F, Kim D, Trepakova ES, Malik MG, Dech SJ, Balasubramanian B, Salata JJ.

Assay Drug Dev Technol. 2008 Apr;6(2):235-41. doi: 10.1089/adt.2007.116.

PMID:
18471077
13.

hERG channel blockade by externally applied quaternary ammonium derivatives.

Choi KH, Song C, Shin D, Park S.

Biochim Biophys Acta. 2011 Jun;1808(6):1560-6. doi: 10.1016/j.bbamem.2011.02.008. Epub 2011 Feb 12.

14.

Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp.

Wacker SJ, Jurkowski W, Simmons KJ, Fishwick CW, Johnson AP, Madge D, Lindahl E, Rolland JF, de Groot BL.

ChemMedChem. 2012 Oct;7(10):1775-83. doi: 10.1002/cmdc.201100600. Epub 2012 Mar 30.

15.

Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias.

Potet F, Lorinc AN, Chaigne S, Hopkins CR, Venkataraman R, Stepanovic SZ, Lewis LM, Days E, Sidorov VY, Engers DW, Zou B, Afshartous D, George AL Jr, Campbell CM, Balser JR, Li M, Baudenbacher FJ, Lindsley CW, Weaver CD, Kupershmidt S.

J Biol Chem. 2012 Nov 16;287(47):39613-25. doi: 10.1074/jbc.M112.380162. Epub 2012 Oct 2.

16.

Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds.

Tao H, Santa Ana D, Guia A, Huang M, Ligutti J, Walker G, Sithiphong K, Chan F, Guoliang T, Zozulya Z, Saya S, Phimmachack R, Sie C, Yuan J, Wu L, Xu J, Ghetti A.

Assay Drug Dev Technol. 2004 Oct;2(5):497-506.

PMID:
15671647
17.

Using electrophysiology and in silico three-dimensional modeling to reduce human Ether-à-go-go related gene K(+) channel inhibition in a histamine H3 receptor antagonist program.

Davenport AJ, Möller C, Heifetz A, Mazanetz MP, Law RJ, Ebneth A, Gemkow MJ.

Assay Drug Dev Technol. 2010 Dec;8(6):781-9. doi: 10.1089/adt.2010.0322. Epub 2010 Dec 6.

PMID:
21133680
18.

A novel method for patch-clamp automation.

Vasilyev D, Merrill T, Iwanow A, Dunlop J, Bowlby M.

Pflugers Arch. 2006 May;452(2):240-7. Epub 2006 Apr 5.

PMID:
16596408
19.

Inhibition of HERG channels by the local anaesthetic articaine.

Siebrands CC, Friederich P.

Eur J Anaesthesiol. 2007 Feb;24(2):148-53. Epub 2006 Aug 29.

PMID:
16938156
20.

Support vector machines classification of hERG liabilities based on atom types.

Jia L, Sun H.

Bioorg Med Chem. 2008 Jun 1;16(11):6252-60. doi: 10.1016/j.bmc.2008.04.028. Epub 2008 Apr 16.

PMID:
18448342
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