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Results: 1 to 20 of 97

1.

CNS-targeted viral delivery of G-CSF in an animal model for ALS: improved efficacy and preservation of the neuromuscular unit.

Henriques A, Pitzer C, Dittgen T, Klugmann M, Dupuis L, Schneider A.

Mol Ther. 2011 Feb;19(2):284-92. doi: 10.1038/mt.2010.271. Epub 2010 Dec 7.

PMID:
21139572
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis.

Pitzer C, Krüger C, Plaas C, Kirsch F, Dittgen T, Müller R, Laage R, Kastner S, Suess S, Spoelgen R, Henriques A, Ehrenreich H, Schäbitz WR, Bach A, Schneider A.

Brain. 2008 Dec;131(Pt 12):3335-47. doi: 10.1093/brain/awn243. Epub 2008 Oct 3.

PMID:
18835867
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis.

Wang LJ, Lu YY, Muramatsu S, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Matsushita T, Hanazono Y, Kume A, Nagatsu T, Ozawa K, Nakano I.

J Neurosci. 2002 Aug 15;22(16):6920-8.

PMID:
12177190
[PubMed - indexed for MEDLINE]
Free Article
4.

G-CSF protects motoneurons against axotomy-induced apoptotic death in neonatal mice.

Henriques A, Pitzer C, Dupuis L, Schneider A.

BMC Neurosci. 2010 Feb 23;11:25. doi: 10.1186/1471-2202-11-25.

PMID:
20178614
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Intraspinal cord delivery of IGF-I mediated by adeno-associated virus 2 is neuroprotective in a rat model of familial ALS.

Franz CK, Federici T, Yang J, Backus C, Oh SS, Teng Q, Carlton E, Bishop KM, Gasmi M, Bartus RT, Feldman EL, Boulis NM.

Neurobiol Dis. 2009 Mar;33(3):473-81. doi: 10.1016/j.nbd.2008.12.003. Epub 2008 Dec 24.

PMID:
19135533
[PubMed - indexed for MEDLINE]
6.

Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2.

Azzouz M, Hottinger A, Paterna JC, Zurn AD, Aebischer P, Büeler H.

Hum Mol Genet. 2000 Mar 22;9(5):803-11.

PMID:
10749988
[PubMed - indexed for MEDLINE]
Free Article
7.

AAV4-mediated expression of IGF-1 and VEGF within cellular components of the ventricular system improves survival outcome in familial ALS mice.

Dodge JC, Treleaven CM, Fidler JA, Hester M, Haidet A, Handy C, Rao M, Eagle A, Matthews JC, Taksir TV, Cheng SH, Shihabuddin LS, Kaspar BK.

Mol Ther. 2010 Dec;18(12):2075-84. doi: 10.1038/mt.2010.206. Epub 2010 Sep 21.

PMID:
20859261
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model.

Azzouz M, Ralph GS, Storkebaum E, Walmsley LE, Mitrophanous KA, Kingsman SM, Carmeliet P, Mazarakis ND.

Nature. 2004 May 27;429(6990):413-7.

PMID:
15164063
[PubMed - indexed for MEDLINE]
9.

Neuroprotection by gene therapy targeting mutant SOD1 in individual pools of motor neurons does not translate into therapeutic benefit in fALS mice.

Towne C, Setola V, Schneider BL, Aebischer P.

Mol Ther. 2011 Feb;19(2):274-83. doi: 10.1038/mt.2010.260. Epub 2010 Nov 23.

PMID:
21102563
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis.

Nanou A, Higginbottom A, Valori CF, Wyles M, Ning K, Shaw P, Azzouz M.

Mol Ther. 2013 Aug;21(8):1486-96. doi: 10.1038/mt.2013.115. Epub 2013 Jun 4.

PMID:
23732987
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury.

Pitzer C, Klussmann S, Krüger C, Letellier E, Plaas C, Dittgen T, Kirsch F, Stieltjes B, Weber D, Laage R, Martin-Villalba A, Schneider A.

J Neurochem. 2010 May;113(4):930-42. doi: 10.1111/j.1471-4159.2010.06659.x. Epub 2010 Feb 25.

PMID:
20202082
[PubMed - indexed for MEDLINE]
12.

Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport.

Lu YY, Wang LJ, Muramatsu S, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Matsushita T, Hanazono Y, Kume A, Nagatsu T, Ozawa K, Nakano I.

Neurosci Res. 2003 Jan;45(1):33-40.

PMID:
12507722
[PubMed - indexed for MEDLINE]
13.

Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

Kaspar BK, Lladó J, Sherkat N, Rothstein JD, Gage FH.

Science. 2003 Aug 8;301(5634):839-42.

PMID:
12907804
[PubMed - indexed for MEDLINE]
Free Article
14.

Persistent, therapeutically relevant levels of human granulocyte colony-stimulating factor in mice after systemic delivery of adeno-associated virus vectors.

Koeberl DD, Bonham L, Halbert CL, Allen JM, Birkebak T, Miller AD.

Hum Gene Ther. 1999 Sep 1;10(13):2133-40.

PMID:
10498245
[PubMed - indexed for MEDLINE]
15.

Lentiviral and adeno-associated vector-based therapy for motor neuron disease through RNAi.

Towne C, Aebischer P.

Methods Mol Biol. 2009;555:87-108. doi: 10.1007/978-1-60327-295-7_7.

PMID:
19495690
[PubMed - indexed for MEDLINE]
16.

Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons.

Yamashita T, Chai HL, Teramoto S, Tsuji S, Shimazaki K, Muramatsu S, Kwak S.

EMBO Mol Med. 2013 Nov;5(11):1710-9. doi: 10.1002/emmm.201302935. Epub 2013 Sep 24.

PMID:
24115583
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Delivery of AAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity.

Dodge JC, Haidet AM, Yang W, Passini MA, Hester M, Clarke J, Roskelley EM, Treleaven CM, Rizo L, Martin H, Kim SH, Kaspar R, Taksir TV, Griffiths DA, Cheng SH, Shihabuddin LS, Kaspar BK.

Mol Ther. 2008 Jun;16(6):1056-64. doi: 10.1038/mt.2008.60. Epub 2008 Apr 1.

PMID:
18388910
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Protective effects of cardiotrophin-1 adenoviral gene transfer on neuromuscular degeneration in transgenic ALS mice.

Bordet T, Lesbordes JC, Rouhani S, Castelnau-Ptakhine L, Schmalbruch H, Haase G, Kahn A.

Hum Mol Genet. 2001 Sep 1;10(18):1925-33.

PMID:
11555629
[PubMed - indexed for MEDLINE]
Free Article
19.

[Development of motor neuron restorative therapy in amyotrophic lateral sclerosis using hepatocyte growth factor].

Aoki M, Warita H, Suzuki N, Itoyama Y.

Rinsho Shinkeigaku. 2009 Nov;49(11):814-7. Review. Japanese.

PMID:
20030218
[PubMed - indexed for MEDLINE]
20.

Double gene therapy with granulocyte colony-stimulating factor and vascular endothelial growth factor acts synergistically to improve nerve regeneration and functional outcome after sciatic nerve injury in mice.

Pereira Lopes FR, Martin PK, Frattini F, Biancalana A, Almeida FM, Tomaz MA, Melo PA, Borojevic R, Han SW, Martinez AM.

Neuroscience. 2013 Jan 29;230:184-97. doi: 10.1016/j.neuroscience.2012.10.025. Epub 2012 Oct 26.

PMID:
23103791
[PubMed - indexed for MEDLINE]

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