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Results: 1 to 20 of 193

1.

Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models.

Liu Z, Xie J, Wu T, Truong T, Auchus RJ, Huang CL.

Hum Mol Genet. 2011 Mar 1;20(5):855-66. doi: 10.1093/hmg/ddq525. Epub 2010 Dec 2.

PMID:
21131289
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome.

Lin SH, Yu IS, Jiang ST, Lin SW, Chu P, Chen A, Sytwu HK, Sohara E, Uchida S, Sasaki S, Yang SS.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17538-43. doi: 10.1073/pnas.1107452108. Epub 2011 Oct 4.

PMID:
21972418
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure.

Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S.

Hum Mol Genet. 2009 Oct 15;18(20):3978-86. doi: 10.1093/hmg/ddp344. Epub 2009 Jul 24.

PMID:
19633012
[PubMed - indexed for MEDLINE]
Free Article
4.

Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.

Hadchouel J, Soukaseum C, Büsst C, Zhou XO, Baudrie V, Zürrer T, Cambillau M, Elghozi JL, Lifton RP, Loffing J, Jeunemaitre X.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18109-14. doi: 10.1073/pnas.1006128107. Epub 2010 Oct 4.

PMID:
20921400
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

WNK kinases regulate thiazide-sensitive Na-Cl cotransport.

Yang CL, Angell J, Mitchell R, Ellison DH.

J Clin Invest. 2003 Apr;111(7):1039-45.

PMID:
12671053
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase.

Liu Z, Wang HR, Huang CL.

J Biol Chem. 2009 May 1;284(18):12198-206. doi: 10.1074/jbc.M806551200. Epub 2009 Feb 25.

PMID:
19244242
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.

Grimm PR, Taneja TK, Liu J, Coleman R, Chen YY, Delpire E, Wade JB, Welling PA.

J Biol Chem. 2012 Nov 2;287(45):37673-90. doi: 10.1074/jbc.M112.402800. Epub 2012 Sep 12.

PMID:
22977235
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.

Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S.

Clin Exp Nephrol. 2012 Aug;16(4):530-8.

PMID:
22294159
[PubMed - indexed for MEDLINE]
9.

Pathogenesis of pseudohypoaldosteronism type 2 by WNK1 mutations.

Bergaya S, Vidal-Petiot E, Jeunemaitre X, Hadchouel J.

Curr Opin Nephrol Hypertens. 2012 Jan;21(1):39-45. doi: 10.1097/MNH.0b013e32834d2fde. Review.

PMID:
22080857
[PubMed - indexed for MEDLINE]
10.

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.

Rinehart J, Kahle KT, de Los Heros P, Vazquez N, Meade P, Wilson FH, Hebert SC, Gimenez I, Gamba G, Lifton RP.

Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16777-82. Epub 2005 Nov 7.

PMID:
16275913
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter.

San-Cristobal P, Ponce-Coria J, Vázquez N, Bobadilla NA, Gamba G.

Am J Physiol Renal Physiol. 2008 Oct;295(4):F1199-206. doi: 10.1152/ajprenal.90396.2008. Epub 2008 Aug 13.

PMID:
18701621
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Kidney-specific WNK1 inhibits sodium reabsorption in the cortical thick ascending limb.

Cheng CJ, Truong T, Baum M, Huang CL.

Am J Physiol Renal Physiol. 2012 Sep;303(5):F667-73. doi: 10.1152/ajprenal.00290.2012. Epub 2012 Jul 11.

PMID:
22791335
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1.

Vallon V, Schroth J, Lang F, Kuhl D, Uchida S.

Am J Physiol Renal Physiol. 2009 Sep;297(3):F704-12. doi: 10.1152/ajprenal.00030.2009. Epub 2009 Jul 1.

PMID:
19570885
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

An inducible transgenic mouse model for familial hypertension with hyperkalaemia (Gordon's syndrome or pseudohypoaldosteronism type II).

Chowdhury JA, Liu CH, Zuber AM, O'Shaughnessy KM.

Clin Sci (Lond). 2013 Jun;124(12):701-8. doi: 10.1042/CS20120430.

PMID:
23336180
[PubMed - indexed for MEDLINE]
15.

Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform.

Subramanya AR, Yang CL, Zhu X, Ellison DH.

Am J Physiol Renal Physiol. 2006 Mar;290(3):F619-24. Epub 2005 Oct 4.

PMID:
16204408
[PubMed - indexed for MEDLINE]
Free Article
16.

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.

Castañeda-Bueno M, Cervantes-Pérez LG, Vázquez N, Uribe N, Kantesaria S, Morla L, Bobadilla NA, Doucet A, Alessi DR, Gamba G.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7929-34. doi: 10.1073/pnas.1200947109. Epub 2012 May 1.

PMID:
22550170
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Kidney-specific WNK1 regulates sodium reabsorption and potassium secretion in mouse cortical collecting duct.

Cheng CJ, Baum M, Huang CL.

Am J Physiol Renal Physiol. 2013 Feb 15;304(4):F397-402. doi: 10.1152/ajprenal.00589.2012. Epub 2012 Nov 28.

PMID:
23195681
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A SPAK isoform switch modulates renal salt transport and blood pressure.

McCormick JA, Mutig K, Nelson JH, Saritas T, Hoorn EJ, Yang CL, Rogers S, Curry J, Delpire E, Bachmann S, Ellison DH.

Cell Metab. 2011 Sep 7;14(3):352-64. doi: 10.1016/j.cmet.2011.07.009.

PMID:
21907141
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Ion and diuretic specificity of chimeric proteins between apical Na(+)-K(+)-2Cl(-) and Na(+)-Cl(-) cotransporters.

Tovar-Palacio C, Bobadilla NA, Cortés P, Plata C, de los Heros P, Vázquez N, Gamba G.

Am J Physiol Renal Physiol. 2004 Sep;287(3):F570-7. Epub 2004 May 18.

PMID:
15149970
[PubMed - indexed for MEDLINE]
Free Article
20.

Cotransporters, WNKs and hypertension: an update.

Flatman PW.

Curr Opin Nephrol Hypertens. 2008 Mar;17(2):186-92. doi: 10.1097/MNH.0b013e3282f5244e. Review.

PMID:
18277153
[PubMed - indexed for MEDLINE]

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