Items per page
Sort by

Send to:

Choose Destination

Links from PubMed

Items: 1 to 20 of 177


The chaperone-dependent ubiquitin ligase CHIP targets HIF-1α for degradation in the presence of methylglyoxal.

Bento CF, Fernandes R, Ramalho J, Marques C, Shang F, Taylor A, Pereira P.

PLoS One. 2010 Nov 29;5(11):e15062. doi: 10.1371/journal.pone.0015062.


PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.

Zhou J, Schmid T, Frank R, Brüne B.

J Biol Chem. 2004 Apr 2;279(14):13506-13. Epub 2004 Jan 15.


Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.

Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL.

J Biol Chem. 2010 Feb 5;285(6):3651-63. doi: 10.1074/jbc.M109.068577. Epub 2009 Nov 23.


Activation of hypoxia-induced transcription in normoxia.

Hägg M, Wennström S.

Exp Cell Res. 2005 May 15;306(1):180-91. Epub 2005 Mar 19.


Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha.

André H, Pereira TS.

J Biol Chem. 2008 Oct 24;283(43):29375-84. doi: 10.1074/jbc.M805919200. Epub 2008 Aug 11.


Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion.

Pagé EL, Chan DA, Giaccia AJ, Levine M, Richard DE.

Mol Biol Cell. 2008 Jan;19(1):86-94. Epub 2007 Oct 17.


HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.

Yu F, White SB, Zhao Q, Lee FS.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9630-5. Erratum in: Proc Natl Acad Sci U S A 2001 Dec 4;98(25):14744.


Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization.

Liu YV, Hubbi ME, Pan F, McDonald KR, Mansharamani M, Cole RN, Liu JO, Semenza GL.

J Biol Chem. 2007 Dec 21;282(51):37064-73. Epub 2007 Oct 26.


Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy.

Barliya T, Mandel M, Livnat T, Weinberger D, Lavie G.

PLoS One. 2011;6(9):e22849. doi: 10.1371/journal.pone.0022849. Epub 2011 Sep 19.


Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein.

Song X, Yao J, Wang F, Zhou M, Zhou Y, Wang H, Wei L, Zhao L, Li Z, Lu N, Guo Q.

Toxicol Appl Pharmacol. 2013 Sep 1;271(2):144-55. doi: 10.1016/j.taap.2013.04.031. Epub 2013 May 23.


OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.

Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL.

Mol Cell. 2005 Feb 18;17(4):503-12.


STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination.

Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, Kim TY, Juhnn YS, Kim SJ, Park JW, Ye SK, Chung MH.

Exp Mol Med. 2008 Oct 31;40(5):479-85.


Estrogen receptor α is a novel target of the Von Hippel-Lindau protein and is responsible for the proliferation of VHL-deficient cells under hypoxic conditions.

Jung YS, Lee SJ, Yoon MH, Ha NC, Park BJ.

Cell Cycle. 2012 Dec 1;11(23):4462-73. doi: 10.4161/cc.22794. Epub 2012 Nov 16.


COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70.

van de Sluis B, Groot AJ, Vermeulen J, van der Wall E, van Diest PJ, Wijmenga C, Klomp LW, Vooijs M.

PLoS One. 2009 Oct 5;4(10):e7332. doi: 10.1371/journal.pone.0007332.


Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E.

Biochem J. 2004 Aug 1;381(Pt 3):761-7.


Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.

Wiesener MS, Münchenhagen PM, Berger I, Morgan NV, Roigas J, Schwiertz A, Jürgensen JS, Gruber G, Maxwell PH, Löning SA, Frei U, Maher ER, Gröne HJ, Eckardt KU.

Cancer Res. 2001 Jul 1;61(13):5215-22.

Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk