Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 95

1.

Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants.

Bosch DE, Kimple AJ, Sammond DW, Muller RE, Miley MJ, Machius M, Kuhlman B, Willard FS, Siderovski DP.

J Biol Chem. 2011 Feb 4;286(5):3351-8. doi: 10.1074/jbc.M110.190496. Epub 2010 Nov 29.

PMID:
21115486
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.

Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP.

Nature. 2002 Apr 25;416(6883):878-81.

PMID:
11976690
[PubMed - indexed for MEDLINE]
3.

Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif.

Kimple RJ, Willard FS, Hains MD, Jones MB, Nweke GK, Siderovski DP.

Biochem J. 2004 Mar 15;378(Pt 3):801-8.

PMID:
14656218
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

GoLoco motif proteins binding to Galpha(i1): insights from molecular simulations.

Khafizov K.

J Mol Model. 2009 Dec;15(12):1491-9. doi: 10.1007/s00894-009-0516-z. Epub 2009 May 14.

PMID:
19437048
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.

Willard FS, Zheng Z, Guo J, Digby GJ, Kimple AJ, Conley JM, Johnston CA, Bosch D, Willard MD, Watts VJ, Lambert NA, Ikeda SR, Du Q, Siderovski DP.

J Biol Chem. 2008 Dec 26;283(52):36698-710. doi: 10.1074/jbc.M804936200. Epub 2008 Nov 4.

PMID:
18984596
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

A peptide core motif for binding to heterotrimeric G protein alpha subunits.

Ja WW, Adhikari A, Austin RJ, Sprang SR, Roberts RW.

J Biol Chem. 2005 Sep 16;280(37):32057-60. Epub 2005 Jul 28.

PMID:
16051611
[PubMed - indexed for MEDLINE]
Free Article
7.

Differential G-alpha interaction capacities of the GoLoco motifs in Rap GTPase activating proteins.

Willard FS, Low AB, McCudden CR, Siderovski DP.

Cell Signal. 2007 Feb;19(2):428-38. Epub 2006 Sep 1.

PMID:
16949794
[PubMed - indexed for MEDLINE]
8.

G alpha selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN.

McCudden CR, Willard FS, Kimple RJ, Johnston CA, Hains MD, Jones MB, Siderovski DP.

Biochim Biophys Acta. 2005 Sep 10;1745(2):254-64.

PMID:
15946753
[PubMed - indexed for MEDLINE]
Free Article
9.

Crystal structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Gαi.

Jia M, Li J, Zhu J, Wen W, Zhang M, Wang W.

J Biol Chem. 2012 Oct 26;287(44):36766-76. doi: 10.1074/jbc.M112.391607. Epub 2012 Sep 5.

PMID:
22952234
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha i1.

Adhikari A, Sprang SR.

J Biol Chem. 2003 Dec 19;278(51):51825-32. Epub 2003 Oct 6.

PMID:
14530282
[PubMed - indexed for MEDLINE]
Free Article
11.

Purification and in vitro functional analyses of RGS12 and RGS14 GoLoco motif peptides.

Kimple RJ, Willard FS, Siderovski DP.

Methods Enzymol. 2004;390:416-36.

PMID:
15488192
[PubMed - indexed for MEDLINE]
12.

D2 dopamine receptor activation of potassium channels is selectively decoupled by Galpha-specific GoLoco motif peptides.

Webb CK, McCudden CR, Willard FS, Kimple RJ, Siderovski DP, Oxford GS.

J Neurochem. 2005 Mar;92(6):1408-18.

PMID:
15748159
[PubMed - indexed for MEDLINE]
13.

A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis.

Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP.

PLoS Pathog. 2012 Feb;8(2):e1002553. doi: 10.1371/journal.ppat.1002553. Epub 2012 Feb 23.

PMID:
22383884
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Computational design of the sequence and structure of a protein-binding peptide.

Sammond DW, Bosch DE, Butterfoss GL, Purbeck C, Machius M, Siderovski DP, Kuhlman B.

J Am Chem Soc. 2011 Mar 30;133(12):4190-2. doi: 10.1021/ja110296z. Epub 2011 Mar 9.

PMID:
21388199
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Return of the GDI: the GoLoco motif in cell division.

Willard FS, Kimple RJ, Siderovski DP.

Annu Rev Biochem. 2004;73:925-51. Review.

PMID:
15189163
[PubMed - indexed for MEDLINE]
16.

G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2).

Willard FS, McCudden CR, Siderovski DP.

Cell Signal. 2006 Aug;18(8):1226-34. Epub 2005 Nov 17.

PMID:
16298104
[PubMed - indexed for MEDLINE]
17.

Structure-based protocol for identifying mutations that enhance protein-protein binding affinities.

Sammond DW, Eletr ZM, Purbeck C, Kimple RJ, Siderovski DP, Kuhlman B.

J Mol Biol. 2007 Aug 31;371(5):1392-404. Epub 2007 Jun 8.

PMID:
17603074
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells.

Vellano CP, Maher EM, Hepler JR, Blumer JB.

J Biol Chem. 2011 Nov 4;286(44):38659-69. doi: 10.1074/jbc.M111.274928. Epub 2011 Aug 31.

PMID:
21880739
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.

Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP.

J Biol Chem. 2001 Aug 3;276(31):29275-81. Epub 2001 May 31.

PMID:
11387333
[PubMed - indexed for MEDLINE]
Free Article
20.

Motion of carboxyl terminus of Galpha is restricted upon G protein activation. A solution NMR study using semisynthetic Galpha subunits.

Anderson LL, Marshall GR, Crocker E, Smith SO, Baranski TJ.

J Biol Chem. 2005 Sep 2;280(35):31019-26. Epub 2005 Jun 27.

PMID:
15983037
[PubMed - indexed for MEDLINE]
Free PMC Article

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk