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Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1.

Leech CA, Chepurny OG, Holz GG.

Vitam Horm. 2010;84:279-302. doi: 10.1016/B978-0-12-381517-0.00010-2. Review.


Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.

Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG.

Islets. 2011 May-Jun;3(3):121-8. Epub 2011 May 1.


Glucagon-like peptide-1 enhances glucokinase activity in pancreatic β-cells through the association of Epac2 with Rim2 and Rab3A.

Park JH, Kim SJ, Park SH, Son DG, Bae JH, Kim HK, Han J, Song DK.

Endocrinology. 2012 Feb;153(2):574-82. doi: 10.1210/en.2011-0259. Epub 2011 Dec 6. Erratum in: Endocrinology. 2012 Apr;153(4):2047.


Glucagon-like peptide 1 potentiates glucotoxicity-diminished insulin secretion via stimulation of cAMP-PKA signaling in INS-1E cells and mouse islets.

Luo G, Kong X, Lu L, Xu X, Wang H, Ma X.

Int J Biochem Cell Biol. 2013 Feb;45(2):483-90. doi: 10.1016/j.biocel.2012.11.016. Epub 2012 Dec 4.


New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic beta-cells.

Holz GG.

Horm Metab Res. 2004 Nov-Dec;36(11-12):787-94. Erratum in: Horm Metab Res. 2005 Feb;37(2):126. Holz, G [corrected to Holz, GG].


Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells.

Leech CA, Holz GG, Chepurny O, Habener JF.

Biochem Biophys Res Commun. 2000 Nov 11;278(1):44-7.


Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells.

Lee YS, Jun HS.

Metabolism. 2014 Jan;63(1):9-19. doi: 10.1016/j.metabol.2013.09.010. Epub 2013 Oct 17. Review.


Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice.

Lamont BJ, Li Y, Kwan E, Brown TJ, Gaisano H, Drucker DJ.

J Clin Invest. 2012 Jan;122(1):388-402. doi: 10.1172/JCI42497. Epub 2011 Dec 19.


GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure.

Kim M, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, Seino S, Simpson JA, Drucker DJ.

Nat Med. 2013 May;19(5):567-75. doi: 10.1038/nm.3128. Epub 2013 Mar 31.


Glucagon-like peptide 1-potentiated insulin secretion and proliferation of pancreatic β-cells.

Ma X, Guan Y, Hua X.

J Diabetes. 2014 Sep;6(5):394-402. doi: 10.1111/1753-0407.12161. Epub 2014 May 22. Review.


Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.

Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K.

Hum Mol Genet. 2009 Jul 1;18(13):2388-99. doi: 10.1093/hmg/ddp178. Epub 2009 Apr 21.


[Molecular mechanism of insulin secretion facilitated by incretin].

Fujita Y, Haneda M.

Nihon Rinsho. 2011 May;69(5):808-12. Japanese.


Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.

Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG.

J Physiol. 2010 Dec 15;588(Pt 24):4871-89. doi: 10.1113/jphysiol.2010.198424. Epub 2010 Nov 1. Erratum in: J Physiol. 2012 Mar 15;590(Pt 6):1511.


Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.

Kelly P, Bailey CL, Fueger PT, Newgard CB, Casey PJ, Kimple ME.

J Biol Chem. 2010 May 21;285(21):15777-85. doi: 10.1074/jbc.M109.069112. Epub 2010 Mar 25.


Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

Gromada J, Brock B, Schmitz O, Rorsman P.

Basic Clin Pharmacol Toxicol. 2004 Dec;95(6):252-62. Review.


Activation of PPARβ/δ protects pancreatic β cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor.

Yang Y, Tong Y, Gong M, Lu Y, Wang C, Zhou M, Yang Q, Mao T, Tong N.

Cell Signal. 2014 Feb;26(2):268-78. doi: 10.1016/j.cellsig.2013.11.019. Epub 2013 Nov 21.


Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells.

Sonoda N, Imamura T, Yoshizaki T, Babendure JL, Lu JC, Olefsky JM.

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6614-9. doi: 10.1073/pnas.0710402105. Epub 2008 Apr 29.


PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.

Chepurny OG, Kelley GG, Dzhura I, Leech CA, Roe MW, Dzhura E, Li X, Schwede F, Genieser HG, Holz GG.

Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E622-33. doi: 10.1152/ajpendo.00630.2009. Epub 2009 Dec 15.

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