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Results: 1 to 20 of 88

1.

Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists.

Luckhurst CA, Stein LA, Furber M, Webb N, Ratcliffe MJ, Allenby G, Botterell S, Tomlinson W, Martin B, Walding A.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):492-6. doi: 10.1016/j.bmcl.2010.10.117. Epub 2010 Oct 27.

PMID:
21094606
[PubMed - indexed for MEDLINE]
2.

Synthesis and biological evaluation of N-alkylated 8-oxybenz[c]azepine derivatives as selective PPARδ agonists.

Luckhurst CA, Ratcliffe M, Stein L, Furber M, Botterell S, Laughton D, Tomlinson W, Weaver R, Chohan K, Walding A.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):531-6. doi: 10.1016/j.bmcl.2010.10.083. Epub 2010 Oct 23.

PMID:
21075629
[PubMed - indexed for MEDLINE]
3.

Discovery of a novel class of PPARdelta partial agonists.

Shearer BG, Patel HS, Billin AN, Way JM, Winegar DA, Lambert MH, Xu RX, Leesnitzer LM, Merrihew RV, Huet S, Willson TM.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5018-22. doi: 10.1016/j.bmcl.2008.08.011. Epub 2008 Aug 9.

PMID:
18722772
[PubMed - indexed for MEDLINE]
4.

Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy.

Keil S, Matter H, Schönafinger K, Glien M, Mathieu M, Marquette JP, Michot N, Haag-Diergarten S, Urmann M, Wendler W.

ChemMedChem. 2011 Apr 4;6(4):633-53. doi: 10.1002/cmdc.201100047. Epub 2011 Mar 11.

PMID:
21400663
[PubMed - indexed for MEDLINE]
5.

Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.

Kasuga J, Nakagome I, Aoyama A, Sako K, Ishizawa M, Ogura M, Makishima M, Hirono S, Hashimoto Y, Miyachi H.

Bioorg Med Chem. 2007 Aug 1;15(15):5177-90. Epub 2007 May 13.

PMID:
17532641
[PubMed - indexed for MEDLINE]
6.

Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells.

Abbot EL, McCormack JG, Reynet C, Hassall DG, Buchan KW, Yeaman SJ.

FEBS J. 2005 Jun;272(12):3004-14.

PMID:
15955060
[PubMed - indexed for MEDLINE]
Free Article
7.

[Design and synthesis of peroxisome proliferator-activated receptor (PPAR) delta agonists and its implication to the driving force to elicit PPAR delta selectivity].

Kasuga J, Oyama T, Nakagome I, Aoyama A, Sako K, Makishima M, Hirono S, Morikawa K, Hashimoto Y, Miyachi H.

Yakugaku Zasshi. 2009 Jun;129(6):709-18. Review. Japanese.

PMID:
19483413
[PubMed - indexed for MEDLINE]
Free Article
8.

Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.

Epple R, Cow C, Xie Y, Azimioara M, Russo R, Wang X, Wityak J, Karanewsky DS, Tuntland T, Nguyêñ-Trân VT, Cuc Ngo C, Huang D, Saez E, Spalding T, Gerken A, Iskandar M, Seidel HM, Tian SS.

J Med Chem. 2010 Jan 14;53(1):77-105. doi: 10.1021/jm9007399.

PMID:
19928766
[PubMed - indexed for MEDLINE]
9.

Minor structural modifications convert a selective PPARalpha agonist into a potent, highly selective PPARdelta agonist.

Weigand S, Bischoff H, Dittrich-Wengenroth E, Heckroth H, Lang D, Vaupel A, Woltering M.

Bioorg Med Chem Lett. 2005 Oct 15;15(20):4619-23.

PMID:
16115765
[PubMed - indexed for MEDLINE]
10.

Design and synthesis of alkoxyindolyl-3-acetic acid analogs as peroxisome proliferator-activated receptor-γ/δ agonists.

Gim HJ, Li H, Lee E, Ryu JH, Jeon R.

Bioorg Med Chem Lett. 2013 Jan 15;23(2):513-7. doi: 10.1016/j.bmcl.2012.11.033. Epub 2012 Nov 22.

PMID:
23265886
[PubMed - indexed for MEDLINE]
11.

Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.

Degenhardt T, Saramäki A, Malinen M, Rieck M, Väisänen S, Huotari A, Herzig KH, Müller R, Carlberg C.

J Mol Biol. 2007 Sep 14;372(2):341-55. Epub 2007 Jul 19.

PMID:
17669420
[PubMed - indexed for MEDLINE]
12.

Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.

Filzen GF, Bratton L, Cheng XM, Erasga N, Geyer A, Lee C, Lu G, Pulaski J, Sorenson RJ, Unangst PC, Trivedi BK, Xu X.

Bioorg Med Chem Lett. 2007 Jul 1;17(13):3630-5. Epub 2007 Apr 24.

PMID:
17512197
[PubMed - indexed for MEDLINE]
13.

Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.

Shearer BG, Wiethe RW, Ashe A, Billin AN, Way JM, Stanley TB, Wagner CD, Xu RX, Leesnitzer LM, Merrihew RV, Shearer TW, Jeune MR, Ulrich JC, Willson TM.

J Med Chem. 2010 Feb 25;53(4):1857-61. doi: 10.1021/jm900464j.

PMID:
20128594
[PubMed - indexed for MEDLINE]
14.

Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry.

Kasuga J, Ishikawa M, Yonehara M, Makishima M, Hashimoto Y, Miyachi H.

Bioorg Med Chem. 2010 Oct 15;18(20):7164-73. doi: 10.1016/j.bmc.2010.08.041. Epub 2010 Aug 24.

PMID:
20843696
[PubMed - indexed for MEDLINE]
15.

Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) delta agonists.

Bratton LD, Filzen GF, Geyer A, Hoffman JK, Lu G, Pulaski J, Trivedi BK, Unangst PC, Xu X.

Bioorg Med Chem Lett. 2007 Jul 1;17(13):3624-9. Epub 2007 Apr 24.

PMID:
17498950
[PubMed - indexed for MEDLINE]
16.
17.

Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.

Krämer DK, Al-Khalili L, Guigas B, Leng Y, Garcia-Roves PM, Krook A.

J Biol Chem. 2007 Jul 6;282(27):19313-20. Epub 2007 May 11.

PMID:
17500064
[PubMed - indexed for MEDLINE]
Free Article
18.

Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists.

Sakuma S, Endo T, Kanda T, Nakamura H, Yamasaki S, Yamakawa T.

Bioorg Med Chem. 2011 May 15;19(10):3255-64. doi: 10.1016/j.bmc.2011.03.053. Epub 2011 Mar 31.

PMID:
21515063
[PubMed - indexed for MEDLINE]
19.

Activation of PPARdelta up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic beta-cells.

Wan J, Jiang L, Lü Q, Ke L, Li X, Tong N.

Biochem Biophys Res Commun. 2010 Jan 15;391(3):1567-72. doi: 10.1016/j.bbrc.2009.12.127. Epub 2009 Dec 27.

PMID:
20040361
[PubMed - indexed for MEDLINE]
20.

1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists.

Epple R, Azimioara M, Russo R, Bursulaya B, Tian SS, Gerken A, Iskandar M.

Bioorg Med Chem Lett. 2006 Jun 1;16(11):2969-73. Epub 2006 Mar 20.

PMID:
16546385
[PubMed - indexed for MEDLINE]

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