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Results: 1 to 20 of 98

1.

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction.

Demaria M, Giorgi C, Lebiedzinska M, Esposito G, D'Angeli L, Bartoli A, Gough DJ, Turkson J, Levy DE, Watson CJ, Wieckowski MR, Provero P, Pinton P, Poli V.

Aging (Albany NY). 2010 Nov;2(11):823-42.

PMID:
21084727
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

STAT3 can serve as a hit in the process of malignant transformation of primary cells.

Demaria M, Misale S, Giorgi C, Miano V, Camporeale A, Campisi J, Pinton P, Poli V.

Cell Death Differ. 2012 Aug;19(8):1390-7. doi: 10.1038/cdd.2012.20. Epub 2012 Mar 9.

PMID:
22402588
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

Gough DJ, Corlett A, Schlessinger K, Wegrzyn J, Larner AC, Levy DE.

Science. 2009 Jun 26;324(5935):1713-6. doi: 10.1126/science.1171721.

PMID:
19556508
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells.

Niu G, Briggs J, Deng J, Ma Y, Lee H, Kortylewski M, Kujawski M, Kay H, Cress WD, Jove R, Yu H.

Mol Cancer Res. 2008 Jul;6(7):1099-105. doi: 10.1158/1541-7786.MCR-07-2177.

PMID:
18644974
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotopic tumor growth.

Lang SA, Moser C, Gaumann A, Klein D, Glockzin G, Popp FC, Dahlke MH, Piso P, Schlitt HJ, Geissler EK, Stoeltzing O.

Clin Cancer Res. 2007 Nov 1;13(21):6459-68.

PMID:
17975158
[PubMed - indexed for MEDLINE]
Free Article
6.

Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.

Chiavarina B, Martinez-Outschoorn UE, Whitaker-Menezes D, Howell A, Tanowitz HB, Pestell RG, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Sep 1;11(17):3280-9. doi: 10.4161/cc.21643. Epub 2012 Aug 16.

PMID:
22894905
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells.

Wan J, Ma J, Mei J, Shan G.

J Exp Clin Cancer Res. 2009 Dec 10;28:150. doi: 10.1186/1756-9966-28-150.

PMID:
20003295
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis.

Lum JJ, Bui T, Gruber M, Gordan JD, DeBerardinis RJ, Covello KL, Simon MC, Thompson CB.

Genes Dev. 2007 May 1;21(9):1037-49. Epub 2007 Apr 16.

PMID:
17437992
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}.

Papadakis AI, Paraskeva E, Peidis P, Muaddi H, Li S, Raptis L, Pantopoulos K, Simos G, Koromilas AE.

Cancer Res. 2010 Oct 15;70(20):7820-9. doi: 10.1158/0008-5472.CAN-10-0215. Epub 2010 Oct 5.

PMID:
20924113
[PubMed - indexed for MEDLINE]
Free Article
10.

ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo.

Moser C, Lang SA, Mori A, Hellerbrand C, Schlitt HJ, Geissler EK, Fogler WE, Stoeltzing O.

BMC Cancer. 2008 Jul 23;8:206. doi: 10.1186/1471-2407-8-206.

PMID:
18651980
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Activated signal transducers and activators of transcription 3 signaling induces CD46 expression and protects human cancer cells from complement-dependent cytotoxicity.

Buettner R, Huang M, Gritsko T, Karras J, Enkemann S, Mesa T, Nam S, Yu H, Jove R.

Mol Cancer Res. 2007 Aug;5(8):823-32.

PMID:
17699108
[PubMed - indexed for MEDLINE]
Free Article
12.

HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.

Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, Watowich SS, Gallick GE.

Oncogene. 2005 Apr 28;24(19):3110-20.

PMID:
15735682
[PubMed - indexed for MEDLINE]
13.

The intracellular delivery of a recombinant peptide derived from the acidic domain of PIAS3 inhibits STAT3 transactivation and induces tumor cell death.

Borghouts C, Tittmann H, Delis N, Kirchenbauer M, Brill B, Groner B.

Mol Cancer Res. 2010 Apr;8(4):539-53. doi: 10.1158/1541-7786.MCR-09-0417. Epub 2010 Apr 6.

PMID:
20371673
[PubMed - indexed for MEDLINE]
Free Article
14.

SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF.

Schumacker PT.

Cancer Cell. 2011 Mar 8;19(3):299-300. doi: 10.1016/j.ccr.2011.03.001.

PMID:
21397853
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells.

Vultur A, Cao J, Arulanandam R, Turkson J, Jove R, Greer P, Craig A, Elliott B, Raptis L.

Oncogene. 2004 Apr 8;23(15):2600-16.

PMID:
15007380
[PubMed - indexed for MEDLINE]
16.

STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination.

Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, Kim TY, Juhnn YS, Kim SJ, Park JW, Ye SK, Chung MH.

Exp Mol Med. 2008 Oct 31;40(5):479-85.

PMID:
18985005
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer.

Haviland R, Eschrich S, Bloom G, Ma Y, Minton S, Jove R, Cress WD.

PLoS One. 2011;6(10):e24923. doi: 10.1371/journal.pone.0024923. Epub 2011 Oct 27.

PMID:
22046235
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis.

Noman MZ, Buart S, Van Pelt J, Richon C, Hasmim M, Leleu N, Suchorska WM, Jalil A, Lecluse Y, El Hage F, Giuliani M, Pichon C, Azzarone B, Mazure N, Romero P, Mami-Chouaib F, Chouaib S.

J Immunol. 2009 Mar 15;182(6):3510-21. doi: 10.4049/jimmunol.0800854.

PMID:
19265129
[PubMed - indexed for MEDLINE]
Free Article
19.

Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727.

Zhang Q, Raje V, Yakovlev VA, Yacoub A, Szczepanek K, Meier J, Derecka M, Chen Q, Hu Y, Sisler J, Hamed H, Lesnefsky EJ, Valerie K, Dent P, Larner AC.

J Biol Chem. 2013 Oct 25;288(43):31280-8. doi: 10.1074/jbc.M113.505057. Epub 2013 Sep 9.

PMID:
24019511
[PubMed - indexed for MEDLINE]
20.

miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells.

Cascio S, D'Andrea A, Ferla R, Surmacz E, Gulotta E, Amodeo V, Bazan V, Gebbia N, Russo A.

J Cell Physiol. 2010 Jul;224(1):242-9. doi: 10.1002/jcp.22126.

PMID:
20232316
[PubMed - indexed for MEDLINE]

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